CRISPR-Cas System in Translational Biotechnology discusses applied and translational aspects of the CRISPR-Cas technology. The book bridges the gap between theoretical knowledge and practical solutions surrounding this emerging and impactful technology in several academic and industrial fields. It is split in five sections: CRISP-Cas fundamentals and advancements; CRISP-Cas in medical biotechnology; CRISP-Cas in environmental biotechnology; CRISP-Cas in food biotechnology; and biosafety, patents and commercialization of CRISP-Cas technology. Written by experts from diverse backgrounds, the content covers the subject and its impact in multiple fields.
It is a valuable resource for graduate students and researchers on bioinformatics, systems biology, and members of the biomedical field and biotechnology industry who are interested in learning more about CRISP-Cas system and its applications.
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Table of Contents
Part I. CRISPR/Cas Fundamentals and advancements 1. CRISPR-Cas Fundamentals and Advances (In Translational Biotechnology) 2. An overview of the CRISPR-Cas System: Applications and Opportunities 3. CRISPR-Cas 9: A solution to rapid befalling global epidemic of bacterial antimicrobial resistance 4. CRISPR-Cas9 and comparison with other gene editing tools Part II. CRISPR/Cas in Medical Biotechnology 5. Molecular engineering of CRISPR-Cas system toward in-vitro diagnostics 6. Genome editing with CRISPR-Cas: The future of infectious disease 7. Role of CRISPR in cancer research and treatment 8. Genome engineering with CRISPR-Cas: Revolutionizing healthcare 9. Role of CRISPR-Cas in cancer treatments 10. Unlocking new ways to tackle tuberculosis using CRIPSR-Cas as potent weapon 11. Translational biotechnology and CRISPR-Cas Part III. CRISPR/Cas in Environmental Biotechnology 12. Dealing environmental problems using CRISPR-Cas tools 13. Translational and evolutionary effect of CRISPR-Cas system in environmental sustainability 14. Employment of CRISPR/Cas on microorganisms for improving the fertility of the soil Part IV. CRISPR/Cas in Food Biotechnology 15. Modifying food bacteria using CRISPR-Cas technology 16. CRISPR-Cas technologies in food security and food revolution 17. CRISPR technology: A revolutionizing tool for crop improvement 18. Biotechnological applications of CRISPR-Cas systems in fungi Part V. Biosafety, patents, and commercialization of CRISPR-Cas technology 19. Commercial application of CRISPR technology in gene therapy 20. Application of CRISPR-Cas in disease diagnosis and management 21. CRISPR: The Janus God of modern science 22. Commercialization and allied aspects of CRISPR techniques
Authors
Swati Joshi Scientist, ICMR-National Institute of Occupational Health (NIOH), Ahmedabad, Gujarat, India(Previous Affiliation: Assistant Professor, School of Life Sciences, Central University of Gujarat, Gandhinagar, India). Dr Swati Joshi earned PhD in Microbiology from University of Delhi, India. During her Ph.D., she focused on developing industrial strains of methylotrophic yeast Pichia pastoris. Currently she is working as Assistant Professor and BioCARe Women Scientist at School of Life Sciences, Central University of Gujarat (CUG), Gandhinagar, where she is engaged in working in the interdisciplinary field of industrial Microbiology and Biotechnology, employing next gen platforms. She has published many peer reviewed scientific papers, reviews and book chapters. She has been conferred with Dr M. J. Thirumalachar Young Scientist Award by Mycological Society of India (MSI) and Young Scientist Award by Association of Microbiologists of India (AMI). She is life member of BRSI, MSI, AMI and Indian Lichenological Society (ILS). Digvijay Verma Department of Environmental Microbiology, School of Earth and Environmental Sciences, Babasaheb Bhimrao Ambedkar University, India. Digvijay Verma has been working in the field of genomics and metagenomics for the last 10 years. He has expertise in heterologous expression of genes from extreme environments into the various Gram-negative and Gram-positive bacterial hosts. His research work on proteins reflects his extensive understanding of industrial biotechnology and extremophilic microorganisms. His laboratory is engaged in exploiting therapeutic bioactive molecules from extreme habitats using metagenomic approaches. He is also in a phase of developing pipelines for robust microbiome analysis. Dr. Verma has also been working on analyzing the oral microbiome from the Indian community and the influence of external risk factors on the overall oral bacterial composition. He is a life member of many scientific organizations like the Association of Microbiologists of India (AMI), Biotech Research Society of India (BRSI), and Indian Science Congress (ISC). He is coauthor of Microorganisms for Sustainable Environment and Health (Elsevier, 2020). Ravi Kr. Gupta Assistant Professor, Department of Environmental Microbiology, School of Earth and Environmental Sciences, Babasaheb Bhimrao Ambedkar University, India. Ravi Kr. Gupta was awarded with several national level scholarships from CSIR and ICMR during his doctoral study and his PhD thesis was awarded Dr. M. M. Dhar Award. Then he moved to the USA as a postdoctoral fellow to enhance his research skills with the state-of-the art techniques in genes and small non-coding RNA regulation in bacteria. Currently he works as assistant professor of microbiology at Babasaheb Bhimrao Ambedkar University (A Central University). His long-term research goals are to better understand the regulatory mechanism of small non-coding RNAs and their role in human and animal pathogens that may lead to the development of alternative therapeutic approach to treat infections. His laboratory is also working to identify novel antimicrobials from natural sources against gram-positive and gram-negative pathogens.
