Epidemiology of Cannabis. Genotoxicity, Neurotoxicity, Epigenomics and Aging

Table of Contents

SECTION 1: Mental Illness Close Parallels between Cannabis Use and Deteriorating US Mental Health at Four Levels Supports and Extends the Epidemiological Salience of Demonstrated Causal Mental Health Relationships: A Geospatiotemporal Study
1. National Trends
2. Regional Trends
3. State Trends
4. Sub-State Trends
5. Geospatial Analysis
6. Causality Criteria

SECTION 2: Autistic Spectrum Disorder Linked Rise of Cannabis Use and Autism Incidence Demonstrated by Close Three Level Geospatiotemporal Relationships, USA, 1990-2011.
7. National Trends
8. Regional Trends
9. State Trends
10. Geospatial Analysis
11. Changes in State Trends
12. Legal Status and Autism
13. Geospatial Analysis of Legal Status and Autism

SECTION 3: Congenital Anomalies Geotemporospatial Analysis of United States 38-44 Congenital Anomalies as a Function of Multiple Cannabinoid- and Substance- Exposure in the Decades of Cannabis Legalization: Phenocopying Thalidomide and Hundred Megabase-Scale Genotoxicity
14. Drug Use by Race
15. Drugs and Defects Overview
16. Chromosomal Anomalies: Anomalies 1:5
17. Gastroschisis: Anomaly 6
18. Atrial Septal Defect (Secundum): Anomaly 7
19. Cardiovascular Defects of Interest: Anomalies 8-11
20. Hawaiian American Review: Anomalies 12-37
21. Conclusion: Time Course, Quintile Analysis, Canada, Thalidomide, Legal Status, Causality

SECTION 4: Cancer and Heritable Cancer Reflections of Heritable Cannabis-Related Genotoxicity in Rising Adult and Pediatric Cancer Rates Across USA in Time- and Ethnicity- Denominated Analyses
22. General Introduction and Overview
23. Sequential Analysis of Cancer Types
24. Geospatiotemporal Modelling Fitted Values
25. Geospatiotemporal Modelling Matrix Multiplication
26. Summary of Geospatiotemporal Modelling
27. Overall Conclusions

SECTION 5: Epigenetics and Aging As modern epigenetic studies provide profound insights into the observed pattern of teratological, cancerogenic and age-accelerated disease it becomes important to consider new findings in detail.
28. Epigenetics of Cannabinoids Introduction
29. Epigenetics of Cannabinoids Historical Studies
30. Epigenetics of Cannabinoids Longitudinal Sperm Study Overview
31. Epigenetics of Cannabinoids Longitudinal Sperm Study Stem Cells
32. Epigenetics of Cannabinoids Longitudinal Sperm Study Chromosomes
33. Epigenetics of Cannabinoids Longitudinal Sperm Teratology Brain
34. Epigenetics of Cannabinoids Longitudinal Sperm Teratology Cardiovasculature
35. Epigenetics of Cannabinoids Longitudinal Sperm Teratology Other Organs
36. Epigenetics of Cannabinoids Longitudinal Sperm Study Carcinogenesis
37. Epigenetics of Cannabinoids Accelerated Aging

Authors

Albert Stuart Reece Professor, University of Western Australia, Australia. Dr. Stuart Reece has been a registered medical practitioner in Australia since 1982. He has worked with a special interest in addiction medicine since 1997 when he was introduced to naltrexone medicine in Perth. He has worked in a variety of hospital and community-based environments in Australia, UK, France, and Papua New Guinea. In addition to his basic medical qualification, Dr Reece holds surgical fellowships from the Royal College of Surgeons of Edinburgh and the Royal College of Physicians and Surgeons of Glasgow, a Fellowship of the Royal Australian College of General Practitioners, and a Doctorate of Medicine in liver transplantation. Dr Reece was appointed as Associate Professor of Medicine at the University of Western Australia in 2010, and a full Professor of Medicine at both the University of Western Australia and the Edith Cowan University in 2018. Gary Kenneth Hulse Professor, University of Western Australia, Australia. Professor Gary Hulse has worked in the area of problem alcohol and drug use for the past 30 years, For the past fourteen years he has held an academic appointment as 'Coordinator of Alcohol and Drug Education and Training' within the Faculty of Medicine, University of Western Australia, based at Sir Charles Gairdner Hospital Perth. Research and clinical activities have been primarily directed at developing evidence- based information which will enhance clinical practice. Between 1992-2009, Professor Hulse chaired the Committee on Alcohol and Drug Education in Medical Schools on behalf of the Committee of Deans Australian and New Zealand Medical Schools. Professor Hulse has published in excess of 150 peer review publications. He is Chief Editor of two evidence based clinical alcohol and drug texts published by Oxford University Press which have been adopted as the standard text for medical training by the Australian Medical Schools [Committee of Deans].