Protein Purification and Isolation Market Report 2025

This Protein Purification and Isolation report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market’s historic and forecast market growth by geography.

The protein purification and isolation market size has grown rapidly in recent years. It will grow from $9.47 billion in 2024 to $10.45 billion in 2025 at a compound annual growth rate (CAGR) of 10.4%. The growth in the historic period can be attributed to increased research and development in biopharmaceuticals, growth ofThe biotechnology industry, rising demand for high-quality proteins, expansion of academic and research institutes, advancements in chromatography techniques.

The protein purification and isolation market size is expected to see rapid growth in the next few years. It will grow to $16.31 billion in 2029 at a compound annual growth rate (CAGR) of 11.8%. The growth in the forecast period can be attributed to growing biologics market, increased funding for life sciences research, demand for personalized medicine, expansion of contract manufacturing organizations (CMOS), increasing demand for rapid screen tests. Major trends in the forecast period include single-use systems in protein purification, high-throughput purification technologies, emphasis on continuous processing, integration of automation in protein purification, focus on sustainable and environmentally friendly practices.

An increase in government spending on research and development in pharmaceuticals and biotechnology is anticipated to drive the growth of the protein purification and isolation market in the future. Research and development involve acquiring knowledge to create new products or find new methods to enhance existing products and services. Increased investment in research and development facilitates the advancement of protein purification processes and offers various benefits, such as purified growth factors, hormones, DNA polymerases, and reverse transcriptase. For example, in March 2023, the White House announced that its budget allocates over $3.4 billion for Cancer Moonshot-related research and development, supporting a range of research programs in laboratory, clinical, public health, and environmental health across multiple departments and agencies. Out of this amount, $2.9 billion is designated for the Department of Health and Human Services, bolstering Cancer Moonshot initiatives at the National Cancer Institute and ARPA-H. Additionally, the budget emphasizes suicide prevention and mental health for veterans, with more than $135 million set aside for the Department of Veterans Affairs medical care. Consequently, the rise in government expenditure on research and development in pharmaceuticals and biotechnology is propelling the growth of the protein purification and isolation markets.

The growing demand for biopharmaceutical products is expected to drive the growth of the protein purification and isolation market in the future. Biopharmaceutical products are large, complex molecules derived from biological sources and are used for therapeutic, diagnostic, or preventive applications. The processes of protein purification and isolation are critical in biopharmaceutical production, as they help obtain highly pure and functional proteins necessary for developing biopharmaceutical drugs such as monoclonal antibodies, vaccines, and therapeutic proteins. For example, in August 2024, the Government of Canada reported that in 2022, domestic exports in the pharmaceutical trade rose to 12.79 billion CAD from 10.71 billion CAD in 2021, while imports increased to 30.21 billion CAD from 26.63 billion CAD in 2021. Therefore, the rising demand for pharmaceutical products is fueling the growth of the protein purification and isolation market.

Major companies in the protein purification and isolation market are developing advanced products, such as Amspher A+, to improve the efficiency and effectiveness of protein separation processes while enhancing yield and purity in biopharmaceutical applications. For example, in September 2024, JSR Life Sciences, LLC, a US-based biotechnology company, launched Amsphere A+. This product features proprietary protein ligand and advanced polymer technology, surpassing its predecessor, Amsphere A3, in terms of binding capacity, alkali stability, and pressure-flow characteristics. These improvements result in greater efficiency in the production process. Overall, Amsphere A+ signifies a notable advancement in performance.

Major players in the protein purification and isolation market are introducing innovative products like affinity resin to enhance their product offerings and maintain a competitive advantage. Affinity resin, a specialized type of chromatography matrix, is designed to selectively bind and purify specific target molecules, particularly proteins or biomolecules, from complex mixtures. Navigo Proteins GmbH introduced an innovative affinity resin in June 2022, utilizing Precision Capturing technology to efficiently capture the glycoprotein gp64 contaminant from the baculovirus insect cell expression system. This resin, designed for flow-through chromatography, allows selective binding, ensuring the target recombinant protein can be eluted without interference, effectively removing contaminants from the production process.

In May 2022, Qiagen N.V., a multinational provider of sample and assay technologies for molecular diagnostics, applied testing, academic research, and pharmaceutical research, acquired BLIRT S.A. for an undisclosed amount. Through this acquisition, Qiagen aims to enhance its capabilities and offerings, ultimately fostering innovation and strengthening its competitive position in these rapidly evolving sectors while providing greater value to its customers and stakeholders. BioLab Innovative Research Technologies (BLIRT S.A.) is a Poland-based biotechnology company engaged in protein purification.

Major companies operating in the protein purification and isolation market include Abcam PLC, Agilent Technologies Inc, Thermo Fisher Scientific Inc., Bio-Rad Laboratories Inc., BioVision Inc., Norgen Biotek Corp., GE Healthcare Technologies Inc., GEA Group AG, Expedeon Ltd., Creative Biostructure, Qiagen NV, Geno Technology Inc., The Merck Group, Labome, Promega Corporation, OPRL Biosciences Pvt. Ltd., Purolite LLC, Takara Bio Inc., F. Hoffmann-La Roche Ltd, Sigma-Aldrich Chemicals Private Limited, Cygnus Technologies LLC, Novasep, Kinnakeet Biotechnology LLC, Cambryn Biologics LLC, Worthington Biochemical Corporation, GenScript Biotech Corporation, Creative BioMart, OriGene Technologies Inc., Proteintech Group Inc., Rockland Immunochemicals Inc., Sino Biological Inc.

North America was the largest region in the protein purification and isolation market in 2024. The regions covered in the protein purification and isolation market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the protein purification and isolation market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Italy, Canada, Spain.

Protein purification and isolation involve the procedures used to separate a specific protein of interest from its surroundings, whether obtained from a cell culture in a laboratory or from the natural environment within a host organism. This process helps identify the existence of the protein from its source based on differences in their properties.

The main types of protein purification and isolation tools are instruments and consumables. Instruments are devices employed to carry out protein purification and isolation processes, which include extraction, precipitation, differential solubilization, ultracentrifugation, and various chromatographic methods. Technologies utilized in these processes encompass ultrafiltration, precipitation, preparative chromatography, electrophoresis, western blotting, dialysis and diafiltration, as well as centrifugation. The end-users of these technologies span academic medical institutes, hospitals and diagnostic centers, pharmaceutical and biotechnology companies, and contract research organizations. Applications for protein purification and isolation include drug screening, protein-protein interaction studies, biomarker discovery, target identification, protein therapeutics, disease diagnostics, and monitoring.

The protein purification and isolation market research report is one of a series of new reports that provides protein purification and isolation market statistics, including protein purification and isolation industry global market size, regional shares, competitors with an protein purification and isolation market share, detailed protein purification and isolation market segments, market trends and opportunities, and any further data you may need to thrive in the protein purification and isolation industry. This protein purification and isolation market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The protein purification and isolation market includes revenues earned by entities by isolating one or a few proteins from a complex mixture. The market value includes the value of related goods sold by the service provider or included within the service offering. Only goods and services traded between entities or sold to end consumers are included.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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