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Herpes Simplex Virus Treatment Market Size, Share & Industry Trends Analysis Report by Drug Type, Type, Distribution Channel, Regional Outlook and Forecast, 2022-2028

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    Report

  • 209 Pages
  • March 2023
  • Region: Global
  • Marqual IT Solutions Pvt. Ltd (KBV Research)
  • ID: 5778879
The Global Herpes Simplex Virus Treatment Market size is expected to reach $2.1 billion by 2028, rising at a market growth of 3.0% CAGR during the forecast period.

Herpes simplex virus is a prevalent sexually transmitted infection (STI) that affects people. Herpes simplex virus type 1 (HSV-1) as well as herpes simplex virus type 2 (HSV-2) are the two types. Cold sores and oral herpes are frequently linked to HSV-1. Therefore, oral intercourse can potentially result in genital herpes. HSV-2 typically causes genital herpes and can also transmit oral herpes during oral intercourse. Both forms of herpes are extremely contagious and can be spread by touching an infected person's saliva or genital secretions.



Herpes severity and frequency are decreased by antiviral drugs like acyclovir, which prevent virus reproduction. The other medications, such as famciclovir and valacyclovir, suppress viral DNA synthesis, stopping the virus from reproducing and generating symptoms. There are many different formulations of these drugs, including topical ointments and oral pills. Since there is presently no effective treatment for HSV infection, the current therapies mainly aim to manage symptoms and lessen the frequency and intensity of outbreaks. However, because of the substantial medical need, this has created in the market for HSV therapies, new medicines are being developed, and there is a rising need for efficient treatments.

Although oral herpes is typically asymptomatic, it can occasionally cause painful blisters or ulcers in or around the mouth. In addition, before sores develop, infected people frequently feel a tingling, burning, or itchy feeling around their mouth. The frequency of these recurrences varies from individual to individual.

Many times, the moderate or asymptomatic symptoms of genital herpes can go unnoticed. One or more anal or genital ulcers or blisters are present when symptoms of genital herpes first appear. Fever, bodily aches, and enlarged lymph nodes are additional signs of a fresh infection. Symptoms can return after the first episode, though they can be quite severe. HSV-1-induced genital herpes seldom recurs in most cases. Recurrent symptoms of HSV-2 are typical. Recurrences, nevertheless, typically don't last as long as the initial episode and become milder over time.

COVID-19 Impact Analysis

Herpes simplex virus infections, which exhibited a moderate development throughout the pandemic, were among the viral infections brought to light by the COVID-19 pandemic due to the necessity of antiviral medications and the requirement for early diagnosis and treatment. Consequently, the demand for treating the herpes simplex virus increased somewhat during the pandemic. Additionally, telemedicine became more widely used, making it simpler for patients to get treatment for herpes infections due to the pandemic's restrictions on transportation and social isolation. The market for herpes simplex virus treatment benefited as a result. Therefore, the market will rise from the pandemic-influenced negative growth and continue to rise in the coming years.

Market Growth Factors

Increasing prevalence of herpes simplex virus infections

As patients look for ways to control their symptoms and lower the risk of transmission, there is a rising demand for HSV therapies as awareness of the value of sexual health grows. Also, healthcare services, like HSV treatment, are now more available due to increases in healthcare spending in developing nations. This has improved healthcare access and raised the demand for HSV treatments. Therefore, the rising prevalence of HSV infection is propelling the demand for treatment and medication, which in turn is boosting the growth of the herpes simplex virus treatment market.

Rising development of HSV testing and medications

Numerous awareness programs have aided in increasing the knowledge about the disease as well as the availability of treatment methods, which in turn has facilitated the uptake of diagnosis and treatment. As herpes infections become more widely known, more individuals are coming forward and getting therapy, which increases the demand for efficient treatments in industrialized nations. Moreover, the increasing availability of common herpes medications in underdeveloped and developing nations has prompted market participants to provide more advanced medication in these regions. Hence, all these factors are propelling the development of the market in the coming years.

Market Restraining Factor

Prevalent side effects of most used herpes medications

The administration of suppressive acyclovir treatments has caused the establishment of acyclovir-resistant HSV strains. This is a problem because the second-line anti-herpes medications, cidofovir and foscarnet, are comparatively more toxic than acyclovir. One report in the literature describes the emergence of acyclovir-resistant HSV in a baby receiving long-term suppressive acyclovir treatment. In addition, a 10-day-old baby with acyclovir-resistant HSV in the larynx is described in another study. Therefore, the side effects of long-term usage of herpes medication may hamper the market's growth in the coming years.

Type Outlook

Based on type, the herpes simplex virus treatment market is categorized into herpes simplex virus-1 infection and herpes simplex virus-2 infection. The herpes simplex virus-2 infection segment procured a considerable growth rate in the herpes simplex virus treatment market in 2021. The rise in cases of HSV-2 infection can be ascribed to an elevated risk of HSV-2 reinfection in individuals with a previous HSV-1 infection. Therefore, appropriate and prompt therapy is crucial because the infection can pass from the mother to the fetus. In addition, businesses are creating novel treatments. Therefore, the segment will grow throughout the forecast period due to increased research into the disease and its rising prevalence.

Drug Type Outlook

On the basis of drug type, the herpes simplex virus treatment market is divided into acyclovir, valacyclovir, and famciclovir. The valacyclovir segment acquired the largest revenue share in the herpes simplex virus treatment market in 2021. HSV infections are becoming more widely known, and patients are acting more proactively by pursuing early treatment, which is why the segment is expanding. Additionally, valacyclovir is used more frequently because of its superior safety rating. The affordability, accessibility, and efficacy of valacyclovir in preventing the herpes virus from replicating in the body and thereby assisting in managing an outbreak's symptoms also increase its demand.

Distribution Channel Outlook

Based on distribution channel, the herpes simplex virus treatment market is segmented into hospital pharmacies, drug store & retail pharmacies, and online providers. The drug store and retail pharmacies segment witnessed the maximum revenue share in the herpes simplex virus treatment market in 2021. Drug shops and retail pharmacies offering a range of drugs and treatments for HSV infections, including antiviral drugs, are credited with the segment's growth. The growing usage of these pharmacies is owed to the simple availability of over-the-counter medications for treating HSV.



Regional Outlook

On the basis of region, the herpes simplex virus treatment market is analyzed across North America, Europe, Asia Pacific, and LAMEA. The North America segment procured the highest revenue share in the herpes simplex virus treatment market in 2021. Numerous influential companies and improvements in the region's herpes simplex virus treatment manufacturing technology are the main market drivers in the region. Additionally, a strong healthcare system, high purchasing power, as well as rising acyclovir use for treating herpes simplex virus infection are anticipated to fuel market expansion.

The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include Abbott Laboratories, Pfizer, Inc., Amneal Pharmaceuticals, Inc., GlaxoSmithKline PLC, Teva Pharmaceuticals Industries Ltd., Glenmark Pharmaceuticals Limited, Fresenius SE & Co. KGaA, Novartis AG, Viatris, Inc., and Emcure Pharmaceuticals Limited.

Scope of the Study

By Drug Type

  • Valacyclovir
  • Acyclovir
  • Famciclovir

By Type

  • Herpes simplex virus-1 Infection
  • Herpes simplex virus-2 Infection

By Distribution Channel

  • Drug Store & Retail Pharmacies
  • Hospital Pharmacies
  • Online Pharmacies

By Geography

  • North America
  • US
  • Canada
  • Mexico
  • Rest of North America
  • Europe
  • Germany
  • UK
  • France
  • Russia
  • Spain
  • Italy
  • Rest of Europe
  • Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Singapore
  • Malaysia
  • Rest of Asia Pacific
  • LAMEA
  • Brazil
  • Argentina
  • UAE
  • Saudi Arabia
  • South Africa
  • Nigeria
  • Rest of LAMEA

Key Market Players

List of Companies Profiled in the Report:

  • Abbott Laboratories
  • Pfizer, Inc.
  • Amneal Pharmaceuticals, Inc.
  • GlaxoSmithKline PLC
  • Teva Pharmaceuticals Industries Ltd.
  • Glenmark Pharmaceuticals Limited
  • Fresenius SE & Co. KGaA
  • Novartis AG
  • Viatris, Inc.
  • Emcure Pharmaceuticals Limited

Unique Offerings

  • Exhaustive coverage
  • The highest number of market tables and figures
  • Subscription-based model available
  • Guaranteed best price
  • Assured post sales research support with 10% customization free

Table of Contents

Chapter 1. Market Scope & Methodology
1.1 Market Definition
1.2 Objectives
1.3 Market Scope
1.4 Segmentation
1.4.1 Global Herpes Simplex Virus Treatment Market, by Drug Type
1.4.2 Global Herpes Simplex Virus Treatment Market, by Type
1.4.3 Global Herpes Simplex Virus Treatment Market, by Distribution Channel
1.4.4 Global Herpes Simplex Virus Treatment Market, by Geography
1.5 Research Methodology
Chapter 2. Market Overview
2.1 Introduction
2.1.1 Overview
2.1.1.1 Market Composition & Scenario
2.2 Key Factors Impacting the Market
2.2.1 Market Drivers
2.2.2 Market Restraints
Chapter 3. Global Herpes Simplex Virus Treatment Market by Drug Type
3.1 Global Valacyclovir Market by Region
3.2 Global Acyclovir Market by Region
3.3 Global Famciclovir Market by Region
Chapter 4. Global Herpes Simplex Virus Treatment Market by Type
4.1 Global Herpes simplex virus-1 Infection Market by Region
4.2 Global Herpes simplex virus-2 Infection Market by Region
Chapter 5. Global Herpes Simplex Virus Treatment Market by Distribution Channel
5.1 Global Drug Store & Retail Pharmacies Market by Region
5.2 Global Hospital Pharmacies Market by Region
5.3 Global Online Pharmacies Market by Region
Chapter 6. Global Herpes Simplex Virus Treatment Market by Region
6.1 North America Herpes Simplex Virus Treatment Market
6.1.1 North America Herpes Simplex Virus Treatment Market by Drug Type
6.1.1.1 North America Valacyclovir Market by Country
6.1.1.2 North America Acyclovir Market by Country
6.1.1.3 North America Famciclovir Market by Country
6.1.2 North America Herpes Simplex Virus Treatment Market by Type
6.1.2.1 North America Herpes simplex virus-1 Infection Market by Country
6.1.2.2 North America Herpes simplex virus-2 Infection Market by Country
6.1.3 North America Herpes Simplex Virus Treatment Market by Distribution Channel
6.1.3.1 North America Drug Store & Retail Pharmacies Market by Country
6.1.3.2 North America Hospital Pharmacies Market by Country
6.1.3.3 North America Online Pharmacies Market by Country
6.1.4 North America Herpes Simplex Virus Treatment Market by Country
6.1.4.1 US Herpes Simplex Virus Treatment Market
6.1.4.1.1 US Herpes Simplex Virus Treatment Market by Drug Type
6.1.4.1.2 US Herpes Simplex Virus Treatment Market by Type
6.1.4.1.3 US Herpes Simplex Virus Treatment Market by Distribution Channel
6.1.4.2 Canada Herpes Simplex Virus Treatment Market
6.1.4.2.1 Canada Herpes Simplex Virus Treatment Market by Drug Type
6.1.4.2.2 Canada Herpes Simplex Virus Treatment Market by Type
6.1.4.2.3 Canada Herpes Simplex Virus Treatment Market by Distribution Channel
6.1.4.3 Mexico Herpes Simplex Virus Treatment Market
6.1.4.3.1 Mexico Herpes Simplex Virus Treatment Market by Drug Type
6.1.4.3.2 Mexico Herpes Simplex Virus Treatment Market by Type
6.1.4.3.3 Mexico Herpes Simplex Virus Treatment Market by Distribution Channel
6.1.4.4 Rest of North America Herpes Simplex Virus Treatment Market
6.1.4.4.1 Rest of North America Herpes Simplex Virus Treatment Market by Drug Type
6.1.4.4.2 Rest of North America Herpes Simplex Virus Treatment Market by Type
6.1.4.4.3 Rest of North America Herpes Simplex Virus Treatment Market by Distribution Channel
6.2 Europe Herpes Simplex Virus Treatment Market
6.2.1 Europe Herpes Simplex Virus Treatment Market by Drug Type
6.2.1.1 Europe Valacyclovir Market by Country
6.2.1.2 Europe Acyclovir Market by Country
6.2.1.3 Europe Famciclovir Market by Country
6.2.2 Europe Herpes Simplex Virus Treatment Market by Type
6.2.2.1 Europe Herpes simplex virus-1 Infection Market by Country
6.2.2.2 Europe Herpes simplex virus-2 Infection Market by Country
6.2.3 Europe Herpes Simplex Virus Treatment Market by Distribution Channel
6.2.3.1 Europe Drug Store & Retail Pharmacies Market by Country
6.2.3.2 Europe Hospital Pharmacies Market by Country
6.2.3.3 Europe Online Pharmacies Market by Country
6.2.4 Europe Herpes Simplex Virus Treatment Market by Country
6.2.4.1 Germany Herpes Simplex Virus Treatment Market
6.2.4.1.1 Germany Herpes Simplex Virus Treatment Market by Drug Type
6.2.4.1.2 Germany Herpes Simplex Virus Treatment Market by Type
6.2.4.1.3 Germany Herpes Simplex Virus Treatment Market by Distribution Channel
6.2.4.2 UK Herpes Simplex Virus Treatment Market
6.2.4.2.1 UK Herpes Simplex Virus Treatment Market by Drug Type
6.2.4.2.2 UK Herpes Simplex Virus Treatment Market by Type
6.2.4.2.3 UK Herpes Simplex Virus Treatment Market by Distribution Channel
6.2.4.3 France Herpes Simplex Virus Treatment Market
6.2.4.3.1 France Herpes Simplex Virus Treatment Market by Drug Type
6.2.4.3.2 France Herpes Simplex Virus Treatment Market by Type
6.2.4.3.3 France Herpes Simplex Virus Treatment Market by Distribution Channel
6.2.4.4 Russia Herpes Simplex Virus Treatment Market
6.2.4.4.1 Russia Herpes Simplex Virus Treatment Market by Drug Type
6.2.4.4.2 Russia Herpes Simplex Virus Treatment Market by Type
6.2.4.4.3 Russia Herpes Simplex Virus Treatment Market by Distribution Channel
6.2.4.5 Spain Herpes Simplex Virus Treatment Market
6.2.4.5.1 Spain Herpes Simplex Virus Treatment Market by Drug Type
6.2.4.5.2 Spain Herpes Simplex Virus Treatment Market by Type
6.2.4.5.3 Spain Herpes Simplex Virus Treatment Market by Distribution Channel
6.2.4.6 Italy Herpes Simplex Virus Treatment Market
6.2.4.6.1 Italy Herpes Simplex Virus Treatment Market by Drug Type
6.2.4.6.2 Italy Herpes Simplex Virus Treatment Market by Type
6.2.4.6.3 Italy Herpes Simplex Virus Treatment Market by Distribution Channel
6.2.4.7 Rest of Europe Herpes Simplex Virus Treatment Market
6.2.4.7.1 Rest of Europe Herpes Simplex Virus Treatment Market by Drug Type
6.2.4.7.2 Rest of Europe Herpes Simplex Virus Treatment Market by Type
6.2.4.7.3 Rest of Europe Herpes Simplex Virus Treatment Market by Distribution Channel
6.3 Asia Pacific Herpes Simplex Virus Treatment Market
6.3.1 Asia Pacific Herpes Simplex Virus Treatment Market by Drug Type
6.3.1.1 Asia Pacific Valacyclovir Market by Country
6.3.1.2 Asia Pacific Acyclovir Market by Country
6.3.1.3 Asia Pacific Famciclovir Market by Country
6.3.2 Asia Pacific Herpes Simplex Virus Treatment Market by Type
6.3.2.1 Asia Pacific Herpes simplex virus-1 Infection Market by Country
6.3.2.2 Asia Pacific Herpes simplex virus-2 Infection Market by Country
6.3.3 Asia Pacific Herpes Simplex Virus Treatment Market by Distribution Channel
6.3.3.1 Asia Pacific Drug Store & Retail Pharmacies Market by Country
6.3.3.2 Asia Pacific Hospital Pharmacies Market by Country
6.3.3.3 Asia Pacific Online Pharmacies Market by Country
6.3.4 Asia Pacific Herpes Simplex Virus Treatment Market by Country
6.3.4.1 China Herpes Simplex Virus Treatment Market
6.3.4.1.1 China Herpes Simplex Virus Treatment Market by Drug Type
6.3.4.1.2 China Herpes Simplex Virus Treatment Market by Type
6.3.4.1.3 China Herpes Simplex Virus Treatment Market by Distribution Channel
6.3.4.2 Japan Herpes Simplex Virus Treatment Market
6.3.4.2.1 Japan Herpes Simplex Virus Treatment Market by Drug Type
6.3.4.2.2 Japan Herpes Simplex Virus Treatment Market by Type
6.3.4.2.3 Japan Herpes Simplex Virus Treatment Market by Distribution Channel
6.3.4.3 India Herpes Simplex Virus Treatment Market
6.3.4.3.1 India Herpes Simplex Virus Treatment Market by Drug Type
6.3.4.3.2 India Herpes Simplex Virus Treatment Market by Type
6.3.4.3.3 India Herpes Simplex Virus Treatment Market by Distribution Channel
6.3.4.4 South Korea Herpes Simplex Virus Treatment Market
6.3.4.4.1 South Korea Herpes Simplex Virus Treatment Market by Drug Type
6.3.4.4.2 South Korea Herpes Simplex Virus Treatment Market by Type
6.3.4.4.3 South Korea Herpes Simplex Virus Treatment Market by Distribution Channel
6.3.4.5 Singapore Herpes Simplex Virus Treatment Market
6.3.4.5.1 Singapore Herpes Simplex Virus Treatment Market by Drug Type
6.3.4.5.2 Singapore Herpes Simplex Virus Treatment Market by Type
6.3.4.5.3 Singapore Herpes Simplex Virus Treatment Market by Distribution Channel
6.3.4.6 Malaysia Herpes Simplex Virus Treatment Market
6.3.4.6.1 Malaysia Herpes Simplex Virus Treatment Market by Drug Type
6.3.4.6.2 Malaysia Herpes Simplex Virus Treatment Market by Type
6.3.4.6.3 Malaysia Herpes Simplex Virus Treatment Market by Distribution Channel
6.3.4.7 Rest of Asia Pacific Herpes Simplex Virus Treatment Market
6.3.4.7.1 Rest of Asia Pacific Herpes Simplex Virus Treatment Market by Drug Type
6.3.4.7.2 Rest of Asia Pacific Herpes Simplex Virus Treatment Market by Type
6.3.4.7.3 Rest of Asia Pacific Herpes Simplex Virus Treatment Market by Distribution Channel
6.4 LAMEA Herpes Simplex Virus Treatment Market
6.4.1 LAMEA Herpes Simplex Virus Treatment Market by Drug Type
6.4.1.1 LAMEA Valacyclovir Market by Country
6.4.1.2 LAMEA Acyclovir Market by Country
6.4.1.3 LAMEA Famciclovir Market by Country
6.4.2 LAMEA Herpes Simplex Virus Treatment Market by Type
6.4.2.1 LAMEA Herpes simplex virus-1 Infection Market by Country
6.4.2.2 LAMEA Herpes simplex virus-2 Infection Market by Country
6.4.3 LAMEA Herpes Simplex Virus Treatment Market by Distribution Channel
6.4.3.1 LAMEA Drug Store & Retail Pharmacies Market by Country
6.4.3.2 LAMEA Hospital Pharmacies Market by Country
6.4.3.3 LAMEA Online Pharmacies Market by Country
6.4.4 LAMEA Herpes Simplex Virus Treatment Market by Country
6.4.4.1 Brazil Herpes Simplex Virus Treatment Market
6.4.4.1.1 Brazil Herpes Simplex Virus Treatment Market by Drug Type
6.4.4.1.2 Brazil Herpes Simplex Virus Treatment Market by Type
6.4.4.1.3 Brazil Herpes Simplex Virus Treatment Market by Distribution Channel
6.4.4.2 Argentina Herpes Simplex Virus Treatment Market
6.4.4.2.1 Argentina Herpes Simplex Virus Treatment Market by Drug Type
6.4.4.2.2 Argentina Herpes Simplex Virus Treatment Market by Type
6.4.4.2.3 Argentina Herpes Simplex Virus Treatment Market by Distribution Channel
6.4.4.3 UAE Herpes Simplex Virus Treatment Market
6.4.4.3.1 UAE Herpes Simplex Virus Treatment Market by Drug Type
6.4.4.3.2 UAE Herpes Simplex Virus Treatment Market by Type
6.4.4.3.3 UAE Herpes Simplex Virus Treatment Market by Distribution Channel
6.4.4.4 Saudi Arabia Herpes Simplex Virus Treatment Market
6.4.4.4.1 Saudi Arabia Herpes Simplex Virus Treatment Market by Drug Type
6.4.4.4.2 Saudi Arabia Herpes Simplex Virus Treatment Market by Type
6.4.4.4.3 Saudi Arabia Herpes Simplex Virus Treatment Market by Distribution Channel
6.4.4.5 South Africa Herpes Simplex Virus Treatment Market
6.4.4.5.1 South Africa Herpes Simplex Virus Treatment Market by Drug Type
6.4.4.5.2 South Africa Herpes Simplex Virus Treatment Market by Type
6.4.4.5.3 South Africa Herpes Simplex Virus Treatment Market by Distribution Channel
6.4.4.6 Nigeria Herpes Simplex Virus Treatment Market
6.4.4.6.1 Nigeria Herpes Simplex Virus Treatment Market by Drug Type
6.4.4.6.2 Nigeria Herpes Simplex Virus Treatment Market by Type
6.4.4.6.3 Nigeria Herpes Simplex Virus Treatment Market by Distribution Channel
6.4.4.7 Rest of LAMEA Herpes Simplex Virus Treatment Market
6.4.4.7.1 Rest of LAMEA Herpes Simplex Virus Treatment Market by Drug Type
6.4.4.7.2 Rest of LAMEA Herpes Simplex Virus Treatment Market by Type
6.4.4.7.3 Rest of LAMEA Herpes Simplex Virus Treatment Market by Distribution Channel
Chapter 7. Company Profiles
7.1 Abbott Laboratories
7.1.1 Company Overview
7.1.2 Financial Analysis
7.1.3 Segmental and Regional Analysis
7.1.4 Research & Development Expense
7.1.5 SWOT Analysis
7.2 Pfizer, Inc.
7.2.1 Company Overview
7.2.2 Financial Analysis
7.2.3 Regional & Segmental Analysis
7.2.4 Research & Development Expense
7.2.5 Recent Strategies and Developments
7.2.5.1 Partnerships, Collaborations, and Agreements
7.3 Amneal Pharmaceuticals, Inc.
7.3.1 Company Overview
7.3.2 Financial Analysis
7.3.3 Segmental Analysis
7.3.4 Research & Development Expenses
7.3.5 Recent Strategies and Developments
7.3.5.1 Approvals and Trials
7.4 GlaxoSmithKline PLC (GSK)
7.4.1 Company Overview
7.4.2 Financial Analysis
7.4.3 Segmental and Regional Analysis
7.4.4 Research & Development Expense
7.4.5 Recent Strategies and Developments
7.4.5.1 Approvals and Trials
7.5 Teva Pharmaceutical Industries Ltd.
7.5.1 Company Overview
7.5.2 Financial Analysis
7.5.3 Regional Analysis
7.5.4 Research & Development Expenses
7.6 Glenmark Pharmaceuticals Limited
7.6.1 Company Overview
7.6.2 Financial Analysis
7.6.3 Regional Analysis
7.6.4 Research & Development Expenses
7.7 Fresenius SE & Co. KGaA
7.7.1 Company Overview
7.7.2 Financial Analysis
7.7.3 Segmental and Regional Analysis
7.7.4 Research & Development Expenses
7.8 Novartis AG
7.8.1 Company Overview
7.8.2 Financial Analysis
7.8.3 Segmental and Regional Analysis
7.8.4 Research & Development Expense
7.9 Viatris, Inc.
7.9.1 Company Overview
7.9.2 Financial Analysis
7.9.3 Segmental Analysis
7.9.4 Research & Development Expense
7.10. Emcure Pharmaceuticals Limited
7.10.1 Company Overview

Companies Mentioned

  • Abbott Laboratories
  • Pfizer, Inc.
  • Amneal Pharmaceuticals, Inc.
  • GlaxoSmithKline PLC
  • Teva Pharmaceuticals Industries Ltd.
  • Glenmark Pharmaceuticals Limited
  • Fresenius SE & Co. KGaA
  • Novartis AG
  • Viatris, Inc.
  • Emcure Pharmaceuticals Limited

Methodology

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