Tangential Flow Filtration Global Market Report 2024

The global tangential flow filtration market has grown rapidly in recent years. It will grow from $1.28 billion in 2023 to $1.44 billion in 2024 at a compound annual growth rate (CAGR) of 12.9%. The growth observed during the historical period can be attributed to several factors, including the expansion of the biopharmaceutical industry, a surge in cell and gene therapy manufacturing, adherence to regulatory compliance, global economic conditions, increased healthcare expenditure, higher adoption rates in vaccine production, and an intensified focus on ensuring drug safety and purity.

The global tangential flow filtration market is expected to see rapid growth in the next few years. It will grow to $2.40 billion in 2028 at a compound annual growth rate (CAGR) of 13.6%. The anticipated growth in the forecast period can be linked to several key factors, including the rise of mRNA vaccine production, expanded utilization in exosome purification, the proliferation of cell culture-based production methods, a heightened emphasis on scalability and flexibility in processes, advancements in membrane chemistry, and increased applications in nanoparticle separation. Key trends expected in the forecast period encompass heightened research and development activities, increased adoption of single-use systems, advancements in membrane technologies, a focus on high-throughput screening techniques, further development in gene therapy and cell therapy approaches, bioprocess intensification, technological integration, and an increased reliance on contract manufacturing organizations (CMOs) for efficient production processes.

The anticipated increase in research and development (R&D) spending within the pharmaceutical and biotechnology industries is poised to drive the growth of the tangential flow filtration market. Tangential flow filtration (TFF) is a crucial processing step in the downstream processing of biopharmaceutical products, aiding in concentration and containment processes. The heightened R&D spending is expected to boost market growth significantly. In February 2022, a report by IQVIA highlighted the acceleration of venture capital deal activity and investment flows in the U.S. pharmaceutical and biotechnology sector, with more than 2,000 deals and $47 billion in deal value occurring in 2021. Additionally, the 15 largest pharmaceutical companies recorded a record $133 billion investment in R&D expenditure in 2021, marking a 44% increase from previous years. This surge in R&D spending is anticipated to generate increased demand for tangential flow filtration in the forecast period.

The rise in healthcare expenditure is set to propel the growth of the tangential flow filtration market. Healthcare expenditure, reflecting the total amount spent on healthcare goods and services within a specific period, plays a significant role in biopharmaceutical production efficiency and cost-effectiveness. Tangential flow filtration (TFF) contributes to streamlined, high-yield processes, reducing operational costs and enhancing overall production efficiency. As of September 2023, the U.S. national health expenditure is projected to grow at an average rate of 5.4% over the 2022-2031 period, outpacing the average GDP growth rate of 4.6%. This increase is expected to result in a rise in the health spending share of GDP from 18.3% in 2021 to 19.6% in 2031. Therefore, the surge in healthcare expenditure is a key driver for the tangential flow filtration market.

Technological advancements are a prominent trend in the tangential flow filtration market, with major companies focusing on developing new technological solutions with larger flow rates and flexibility across various elements. These advancements enable key players to gain a competitive edge in the market. In September 2021, ABEC, a U.S.-based company providing engineered solutions and services for biotech manufacturing, launched custom single run (CSR) tangential flow filtration (TFF) systems. These systems achieve flow rates greater than 240 liters per minute across cassette-type filter areas up to 40m2, matching or exceeding levels seen in stainless steel systems. This innovation triples the levels currently available for single-use TFF, resulting in reduced process times, improved batch turnaround, and increased productivity.

Key players in the tangential flow filtration market are introducing innovative products, including holder-free, self-contained Tangential Flow Filtration (TFF) devices, to maintain and enhance their positions in the market. The term 'holder-free' denotes a design where a product does not require a separate supporting structure, while 'self-contained' describes a system that is complete and independent, needing no external components for operation. In November 2023, Repligen, a US-based provider of materials used in the manufacture of biological drugs, launched the TangenX SC, marking the industry's first holder-free, self-contained TFF device. The TangenX SC incorporates technology well-suited for the production of biologics, particularly in scenarios where fully closed systems are critical or ideal. This includes applications in the manufacture of antibody drug conjugates (ADCs), viral vectors, nucleic acids, lipid nanoparticles, as well as monoclonal antibody and recombinant protein production. The device is aseptically closed and gamma irradiated, reducing bioburden risk and allowing its use in Controlled not Classified (CNC) manufacturing environments. This innovative solution expands the selection of flat sheet TFF offerings for biopharmaceutical manufacturing customers.

In November 2021, Donaldson Company Inc., a US-based vertically integrated filtration company, completed the acquisition of Solaris Biotechnology Srl for $46 million. This strategic acquisition positions Donaldson to provide its food and beverage clients with more comprehensive solutions and greater access to crucial areas in the biopharmaceutical and other life sciences sectors. Solaris Biotechnology Srl, based in Italy, specializes in the manufacturing of bioprocessing equipment and tangential flow filtration systems. The acquisition reinforces Donaldson's commitment to offering holistic solutions and strengthening its presence in key markets.

Major companies operating in the tangential flow filtration market report are Danaher Corporation, Koch Membrane Systems Inc., Merck Millipore, Sartorius AG, GE Healthcare, Parker Hannifin Corporation, Repligen Corporation, Alfa Laval Corporate AB, Andritz AG, Artesyn Biosolutions, Bionet America Inc., Cole-Parmer Instrument Company LLC, Sterlitech Corporation, Mantec Technical Ceramics Ltd., Meissner Filtration Products Inc., Spectrum Inc., TangenX Technology Corporation, Watersep Bioseparations Corporation, Pall Corporation, Novasep Holding SAS, Pendotech Inc., Asahi Kasei Corporation, Graver Technologies, GEA Group Aktiengesellschaft, Filtration Group Corporation, 3M Company, Amazon Filters Ltd., Advantec MFS Inc., Membrane Solutions LLC, Sterigenics International LLC, Entegris Inc.

North America was the largest region in the tangential flow filtration market in 2023. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the tangential flow filtration market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the tangential flow filtration market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The primary products within tangential flow filtration include reusable systems, single-use systems, and membrane filters. Reusable systems can either undergo cleaning for reuse or be disposed of after a single application. These systems utilize a filter membrane to compel the solution being filtered through its pores. Tangential flow filtration technologies encompass ultrafiltration, microfiltration, and reverse osmosis, catering to various applications like bioprocessing, viral vector purification, vaccine production, among others.

This report provides tangential flow filtration market statistics, including tangential flow filtration industry global market size, regional shares, competitors with a tangential flow filtration market share, detailed tangential flow filtration market segments, market trends and opportunities, and any further data you may need to thrive in the tangential flow filtration industry. This tangential flow filtration market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The tangential flow filtration market consists of sales of feed pumps, filters, membranes and feed reservoirs. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.


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