Tangential Flow Filtration Market Report 2025

The tangential flow filtration market size has grown rapidly in recent years. It will grow from $1.41 billion in 2024 to $1.58 billion in 2025 at a compound annual growth rate (CAGR) of 12.1%. The growth in the historic period can be attributed to biopharmaceutical industry growth, rise in cell and gene therapy manufacturing, regulatory compliance, global economic conditions, healthcare expenditure, increased adoption in vaccine production, focus on drug safety and purity.

The tangential flow filtration market size is expected to see rapid growth in the next few years. It will grow to $2.74 billion in 2029 at a compound annual growth rate (CAGR) of 14.8%. The growth in the forecast period can be attributed to emergence of mRNA vaccine production, increased use in exosome purification, expansion of cell culture-based production, focus on scalability and flexibility, enhancements in membrane chemistry, increasing application in nanoparticle separation. Major trends in the forecast period include research and development activities, single-use systems, advanced membrane technologies, high-throughput screening, gene therapy and cell therapy, bioprocess intensification, technological integration, contract manufacturing organizations (CMOs).

Rising research and development (R&D) spending in the pharmaceutical and biotechnology industries is expected to drive the growth of the tangential flow filtration (TFF) market. TFF is commonly used in the downstream processing of biopharmaceutical products, particularly for concentration and containment processes. The increase in R&D spending will support the market's expansion. For example, in July 2024, according to GOV.UK, the UK's business enterprise sector invested £9 billion ($11.7 billion) in pharmaceutical R&D in 2022, equivalent to 0.36% of the country's GDP. Pharmaceutical R&D accounted for 18% of all business R&D in the UK, the highest percentage among all product sectors. Therefore, the growing R&D expenditure is anticipated to boost demand for TFF in the forecast period.

An increase in healthcare expenditure is expected to further propel the growth of the tangential flow filtration market. Healthcare expenditure refers to the total financial outlay on healthcare goods and services over a specific period, usually measured annually or per capita. Tangential flow filtration plays a crucial role in healthcare spending by enhancing the efficiency and cost-effectiveness of biopharmaceutical production. The streamlined, high-yield processes enabled by TFF help reduce operational costs and improve overall production efficiency. For instance, in September 2023, according to an article published by the Centers for Medicare & Medicaid Services (CMS), a U.S.-based federal health agency, the national health expenditure in the U.S. is projected to grow at an average rate of 5.4% from 2022 to 2031, outpacing the projected average GDP growth of 4.6%. This increase will raise the health spending share of GDP from 18.3% in 2021 to 19.6% by 2031. As a result, the rise in healthcare expenditure is driving the TFF market.

Major companies in the tangential flow filtration (TFF) market are focusing on developing innovative solutions, such as laboratory-focused TFF cassettes, to improve efficiency and precision in bioprocessing applications. Laboratory-focused tangential flow filtration cassettes are specialized devices used in labs for the TFF process. For example, in September 2024, Sartorius AG, a Germany-based provider of pharmaceutical and laboratory equipment, introduced the Vivaflow SU, a next-generation TFF cassette. This system handles feed volumes ranging from 100 mL to 1,000 mL and is designed for ultrafiltration and diafiltration processes. It simplifies setup with easy-to-use features, requiring no complex settings and being compatible with common laboratory pumps. The environmentally friendly design incorporates eco-friendly materials and uses 30.5% less plastic than previous models, reducing its environmental impact.

Leading companies in the TFF market are introducing innovative products like holder-free, self-contained TFF devices to maintain their market position. A holder-free design eliminates the need for a separate supporting structure, while self-contained systems operate independently, without external components. In November 2023, Repligen, a US-based provider of bioprocessing materials, launched the TangenX SC, the industry's first holder-free, self-contained TFF device. This technology is particularly suited for biologics manufacturing, including antibody-drug conjugates (ADCs), viral vectors, nucleic acids, and lipid nanoparticles, and can be used in monoclonal antibody and recombinant protein production. The system is aseptically closed and gamma-irradiated, minimizing bioburden risk, and can be utilized in Controlled Not Classified (CNC) manufacturing environments. This product expands the range of flat sheet TFF options for biopharmaceutical manufacturers.

In July 2024, Repligen Corporation, a US-based life sciences company specializing in bioprocessing, acquired Tantti Laboratory Inc. for approximately $1.139 billion. This strategic acquisition strengthens Repligen’s leadership in bioprocessing technologies and helps meet the increasing demand for efficient purification solutions. Tantti Laboratory Inc., based in Taiwan, provides biotherapies and next-generation biomaterials and is committed to advancing innovative solutions for the future.

Major companies operating in the tangential flow filtration market are Danaher Corporation, Koch Membrane Systems Inc., Merck Millipore, Sartorius AG, GE Healthcare, Parker Hannifin Corporation, Repligen Corporation, Alfa Laval Corporate AB, Andritz AG, Sterlitech Corporation, Meissner Filtration Products Inc., Spectrum Inc., TangenX Technology Corporation, Watersep Bioseparations Corporation, Pall Corporation, Novasep Holding SAS, Asahi Kasei Corporation, Graver Technologies, GEA Group Aktiengesellschaft, Filtration Group Corporation, 3M Company, Amazon Filters Ltd., Advantec MFS Inc., Membrane Solutions LLC, Entegris Inc.

North America was the largest region in the tangential flow filtration market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the tangential flow filtration market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the tangential flow filtration market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Tangential flow filtration stands as a key bioprocessing technique primarily applied in downstream processing and extraction. This method facilitates the swift and effective separation and purification of biomolecules, finding extensive use across various biological disciplines such as immunology, protein chemistry, molecular biology, biochemistry, and microbiology.

The primary products within tangential flow filtration include reusable systems, single-use systems, and membrane filters. Reusable systems can either undergo cleaning for reuse or be disposed of after a single application. These systems utilize a filter membrane to compel the solution being filtered through its pores. Tangential flow filtration technologies encompass ultrafiltration, microfiltration, and reverse osmosis, catering to various applications like bioprocessing, viral vector purification, vaccine production, among others.

The tangential flow filtration market research report is one of a series of new reports that provides tangential flow filtration market statistics, including tangential flow filtration industry global market size, regional shares, competitors with a tangential flow filtration market share, detailed tangential flow filtration market segments, market trends and opportunities, and any further data you may need to thrive in the tangential flow filtration industry. This tangential flow filtration market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The tangential flow filtration market consists of sales of feed pumps, filters, membranes and feed reservoirs. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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