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Motor System Disorders, Part I. Normal Physiology and Function and Neuromuscular Disorders. Handbook of Clinical Neurology Volume 195

  • Book

  • September 2023
  • Elsevier Science and Technology
  • ID: 5789779
Motor System Disorders, Volume 195, Part One, Normal Physiology and Function and Neuromuscular Disorders summarizes recent advances and best practice for understanding normal physiology and function of the larger motor system as well as the diagnosis, course, and treatment of neuromuscular disorders. The work includes neuroanatomy, circuits, and synapses, and discusses how different parts of the brain contribute to motor control, including both vestibular and cerebellar motor control, as well as the influences of the parietal and frontal lobes. Diagnostic methods include genetic evaluation, electrodiagnosis, pathology, and brain imaging. Neuromuscular disorders of both children and adults are included.

Table of Contents

Section 1. Normal Physiology and Function
1. Skeletal muscle structure, physiology, and function
2. Upper and lower motor neuron neurophysiology and motor control
3. Vestibular motor control
4. Autonomic failure: Clinicopathologic, physiologic, and genetic aspects
5. Gait control by the frontal lobe
6. Parietal control of hand movement
7. Immunology and microbiome: Implications for motor systems
8. COVID-19 (novel SARS-CoV-2) neurological illness

Section 2. Clinical and Laboratory Diagnosis
9. Neurogenetic motor disorders
10. Neuromuscular electrodiagnosis
11. Quantitative electrodiagnosis of the motor unit
12. Neuromuscular pathology
13. Electrophysiological assessment of peripheral and central autonomic disorders
14. On the path to evidence-based therapy in neuromuscular disorders
15. Advances in the neuroimaging of motor disorders
16. Sleep-related motor disorders

Section 3. Neuromuscular Disorders
17. Neonatal and infantile hypotonia
18. Autoimmune inflammatory myopathies
19. Childhood muscular dystrophies
20. Distal myopathy
21. Muscle channelopathies
22. Congenital myopathies
23. Mitochondrial encephalomyopathy
24. Autoimmune polyneuropathies
25. Hereditary neuropathy
26. Acute/chronic inflammatory polyradiculoneuropathy
27. Myasthenia gravis and congenital myasthenic syndromes
28. Adult and childhood vasculitis
29. Critical illness-associated weakness and related motor disorders

Authors

David S. Younger Affiliated Professor of Neuroscience, City University of New York Medical School, New York, NY, United States; Attending Physician in Neurology, White Plains Hospital, White Plains, NY, United States. David S. Younger MD DrPH, MPH MS, Affiliate Professor of Neuroscience at City University of New York Medical School and Attending Physician at White Plains Hospital, NY, has vast experience in both clinical and academic neurology and public health. He mentors students at his alma mater Columbia University College of Physicians and Surgeons. He has been Board certified in Neurology, Internal Medicine, Electrodiagnostic Medicine (AANEM) and Neurophysiology (ABCN). As Associate Editor of the Seminars in Neurology he prepared the 1st edition of his widely-acclaimed textbook, Motor Disorders, now in its 4th edition. He is best recognized as a highly trained electrophysiologist and neuromuscular specialist. For the past decade his work has focused on autoimmunity of the nervous system and the use of immunotherapy and most recently, in COVID-19 neurological illnesses. He is the author of Human Lyme Neuroborreliosis, Science of Medical Cannabis, The Vasculitides, and The Autoimmune Brain; and he has been Guest Editor of the multiple volumes of the Neurological Clinics. He has also authored more than 300 peer-reviewed articles, book chapters, correspondence and scientific abstracts on a wide variety of topics.