Pediatric Epilepsy Surgery Techniques: Controversies and Evidence offers clinicians a roadmap for navigating the complex decision-making process involved in selecting surgical interventions for children with drug-resistant epilepsy. Over the last decade, the landscape of pediatric epilepsy surgery has undergone substantial transformation, marked by the introduction of several emerging technologies that are now supported by an expanding body of evidence, yet leading to a wide range of treatment practices. This book addresses several decision-making dichotomies in pediatric epilepsy surgery, both in terms of established and novel surgical modalities and techniques. The book explores long-standing debated topics, such as the relative benefits of disconnective compared to resective strategies, the utility of surgical adjuncts like intra-operative electrocorticography, as well as rationales for different surgical approaches, namely selective amygdalo-hippocampectomy versus anteromesial temporal lobectomy. Further, it addresses dichotomies between traditional approaches and contemporary modalities, such as microsurgical resection versus laser interstitial thermal therapy. Chapters also offer comparisons of modern technologies, such as different neuromodulation strategies, including vagus nerve stimulation, deep brain stimulation, and responsive neurostimulation.
This book provides readers with the relevant scientific literature and expert commentary to inform evidence-based approaches to surgical care in pediatric drug-resistant epilepsy.
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Table of Contents
Part 1: Evidence in pediatric epilepsy surgery1. Evidence in pediatric epilepsy surgery
Churl-Su Kwon and Varun Ramanan Subramaniam
2. Controversies in the timing of pediatric epilepsy surgery-is earlier better?
Jarod L. Roland
Part 2: Invasive investigation
3. Electroencephalographic evaluation of epileptogenicity-traditional versus novel biomarkers to guide surgery
Eroshini Swarnalingam and Julia Jacobs
4. Invasive monitoring: stereoelectroencephalography (sEEG) versus subdural electrode (SDE) versus hybrid evaluation
Taylor J. Abel, Luis Fernandez and Joseph Garcia
Part 3: Resective or ablative surgery
5. Intraoperative adjuncts to optimize the surgical treatment of drug-resistant epilepsy-do new tools improve outcome?
Trang Tran, Frederic Leblond and Roy W.R. Dudley
6. Medial temporal lobe epilepsy-selective amygdalohippocampectomy versus anterior temporal lobectomy
Christian Dorfer
7. Epilepsy in eloquent cortex: resection versus responsive neurostimulation
Saadi Ghatan
8. Lesional epilepsy: lesionectomy versus ECoG-guided resection
Shimrit Sibony-Uliel and Jonathan Roth
9. Insular/perisylvian epilepsy: Open resection versus stereotactic ablation (MR-guided laser ablation/radiofrequency thermocoagulation) versus responsive neurostimulation
Vincent Joris, Jessica Royer and Alexander G. Weil
Part 4: Hypothalamic hamartoma
10. Hypothalamic hamartoma-open surgery versus endoscopic surgery versus stereotactic radiosurgery versus stereotactic ablation (MR-guided laser ablation/Radiofrequency ablation) versus MRFUS
Santiago Candela-Canto, Roberto Martinez Alvarez and Jose Hinojosa Mena-Bernal
Part 5: Tuberous sclerosis complex
11. Resective surgery in tuberous sclerosis complex-related epilepsy: tuberectomy and tuberectomy plus
Shuli Liang, Zhirong Wei, Jiaqi Wang and Feng Zhai
Part 6: Disconnective procedures
12. Functional hemispheric surgery-vertical versus lateral approach
Jia-Shu Chen, H. Westley Phillips and Aria Fallah
13. Minimally invasive hemispherotomy-endoscopic, radiofrequency and robotic techniques
Poodipedi Sarat Chandra and Manjari Tripathi
14. Lobar/multilobar epilepsy: resection versus disconnection
Vejay N. Vakharia and Martin M. Tisdall
15. Corpus callosotomy: anterior two-thirds (two-stage) versus complete (one-stage)
Meena Vessell and Robert J. Bollo
Part 7: Neuromodulation
16. Temporal lobe epilepsy with preserved function: multiple hippocampal transection versus neuromodulation (deep brain stimulation, responsive neurostimulation)
Logan Massman and Sean Lew
17. Neuromodulation: comparison of vagus nerve stimulation, deep brain stimulation, and responsive eurostimulation
Nebras M. Warsi, Hrishikesh Suresh and George M. Ibrahim
Authors
Aria Fallah Pediatric and Adult Epilepsy Neurosurgeon, Ronald Reagan UCLA Medical Center and UCLA Mattel Children's Hospital Associate Professor of Neurosurgery and Pediatrics, David Geffen School of Medicine at UCLA.Dr. Aria Fallah is a paediatric and adult epilepsy neurosurgeon at the Ronald Reagan UCLA Medical Center and UCLA Mattel Children's Hospital. He serves as the Director of Epilepsy Surgery and Pediatric Neurosurgery at UCLA. He holds the Alfonsina Q. Davies Chair in Epilepsy Research. Dr. Fallah is an Associate Professor of Neurosurgery and Pediatrics at the David Geffen School of Medicine at UCLA, as well as an Associate Professor in Health Policy & Management at the UCLA Fielding School of Public Health. He is also a member of the Brain Research Institute at UCLA. In addition to his medical qualifications, he has obtained his Executive MBA from the UCLA Anderson School of Management. His clinical practice focuses on the surgical management of children with medically intractable epilepsy.
George M. Ibrahim Paediatric Neurosurgeon, The Hospital for Sick Children (SickKids); Associate Professor?in?Biomedical Engineering, Institute of Medical Sciences; Department of Surgery, University of Toronto, Canada.Dr. George Ibrahim is the Abe Bresver Chair in Functional Neurosurgery at the Hospital for Sick Children and Associate Professor in Surgery, Biomedical Engineering and Medical Science at the University of Toronto. He is a Scientist in the Program in Neuroscience and Mental Health at the Hospital for Sick Children Research Institute. He is the Surgical Director of the pediatric DBS program.
Alexander G. Weil Pediatric Neurosurgeon, Sainte-Justine University Hospital; Associate Professor, Department of Surgery and Neuroscience, University of Montreal, Canada.Dr. Weil is a pediatric and epilepsy neurosurgeon at Sainte-Justine University Hospital and the University of Montreal Hospital Center (CHUM). He serves as an Associate Professor in the Departments of Surgery and Neuroscience at the University of Montreal. Additionally, he is a Surgeon-Scientist in the Brain and Child Development Axis at the CHU Sainte-Justine Research Institute. Dr. Weil is the Director of the University of Montreal Pediatric Neurosurgery Fellowship and the research representative for the University of Montreal Division of Neurosurgery. His clinical practice and expertise focus on the investigation and treatment of drug-resistant epilepsy in both pediatric and adult populations.
