Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities is a complete reference to this key cellular process involved in homeostasis. The book addresses the machinery and mechanisms of mitophagy, including an overview of mito-biogenesis and dynamics and specific types of mitophagy. Other sections cover mitophagy across the human lifespan, from development to aging, discussing the interplay between inflammation and several conditions. The final part covers therapeutic opportunities presented by targeting mitophagy, including inducers and inhibitors, targeting strategies, and studies specific to cardioprotection and neurodegenerative diseases prevention.
This is the ideal reference for cellular and molecular biologists needing a consistent and thorough overview of the subject, as well as research physicians in areas where mitochondria play a key role.
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Table of Contents
About the editor
Preface
1. PINK1-Parkin mitochondrial quality control pathway in Parkinson’s disease
2. Ubiquitin-independent mitophagy: mechanisms and pathophysiological functions
3. Role of AMPK/ULK1 signaling in mitophagy
4. Mitochondrial proteostasis mechanisms (AAA proteases including Lon, proteasomes, CLpP)
5. MitoUPR
6. Mitochondria Derived Vesicles: from Quality Control to Inflammation and Extracellular Vesicles
7. Molecular Regulation of Mitochondrial Turnover by Exercise: Tissue Adaptation through Mitochondrial Biogenesis and Mitophagy
8. Role of mitophagy and mitochondria in aging and cellular senescence
9. Mitophagy in erythropoiesis
10. The dual role of mitophagy in cancer and its targeting for effective anticancer therapy
11. Mitophagy in brain and neurodegenerative disease
12. Anti-aging role of mitophagy
13. Mitophagy in age-associated disease
14. Mitophagy inducers as potential therapeutic agents
15. Transcription factor EB (TFEB) in mitochondrial quality control
16. Cardioprotection through mitophagy
17. Fasting, mitophagy, and aging
18. Aldehydes, Mitophagy, and the Pathogenesis of Alcohol-Associated and Metabolic Dysfunction-Associated Steatohepatitis
19. Mitochondrial dynamics and quality control in alcohol-associated liver disease and liver tumorigenesis
20. Mitophagy in Yeast
21. Sphingolipid metabolism in the regulation of mitophagy: Implications in cancer therapy, immune cell function and neurodegeneration
22. Formation of mitophagosomes
23. Mitophagy in Hepatic Ischemia/Reperfusion
