Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities is a complete reference to this key cellular process involved in homeostasis. The book addresses the machinery and mechanisms of mitophagy, including an overview of mito-biogenesis and dynamics and specific types of mitophagy. Other sections cover mitophagy across the human lifespan, from development to aging, discussing the interplay between inflammation and several conditions. The final part covers therapeutic opportunities presented by targeting mitophagy, including inducers and inhibitors, targeting strategies, and studies specific to cardioprotection and neurodegenerative diseases prevention.
This is the ideal reference for cellular and molecular biologists needing a consistent and thorough overview of the subject, as well as research physicians in areas where mitochondria play a key role.
Table of Contents
About the editor Preface 1. PINK1-Parkin mitochondrial quality control pathway in Parkinson’s disease 2. Ubiquitin-independent mitophagy: mechanisms and pathophysiological functions 3. Role of AMPK/ULK1 signaling in mitophagy 4. Mitochondrial proteostasis mechanisms (AAA proteases including Lon, proteasomes, CLpP) 5. MitoUPR 6. Mitochondria Derived Vesicles: from Quality Control to Inflammation and Extracellular Vesicles 7. Molecular Regulation of Mitochondrial Turnover by Exercise: Tissue Adaptation through Mitochondrial Biogenesis and Mitophagy 8. Role of mitophagy and mitochondria in aging and cellular senescence 9. Mitophagy in erythropoiesis 10. The dual role of mitophagy in cancer and its targeting for effective anticancer therapy 11. Mitophagy in brain and neurodegenerative disease 12. Anti-aging role of mitophagy 13. Mitophagy in age-associated disease 14. Mitophagy inducers as potential therapeutic agents 15. Transcription factor EB (TFEB) in mitochondrial quality control 16. Cardioprotection through mitophagy 17. Fasting, mitophagy, and aging 18. Aldehydes, Mitophagy, and the Pathogenesis of Alcohol-Associated and Metabolic Dysfunction-Associated Steatohepatitis 19. Mitochondrial dynamics and quality control in alcohol-associated liver disease and liver tumorigenesis 20. Mitophagy in Yeast 21. Sphingolipid metabolism in the regulation of mitophagy: Implications in cancer therapy, immune cell function and neurodegeneration 22. Formation of mitophagosomes 23. Mitophagy in Hepatic Ischemia/Reperfusion
