Adenosine A2A Receptor Antagonists, Volume 170 in the International Review of Neurobiology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including A2A Adenosine Receptor Agonists, Antagonists, Inverse Agonists and Partial Agonist, Chemistry - agonists, antagonists, partial agonists, inverse agonists, Functional roles of adenosine receptors - biochemistry and neuronal plasticity, A2A and Depression, A2AR and glial function, The adenosine A2A receptor in the basal ganglia: expression in health and disease, heteromerization, functional selectivity and signaling, How and why A2a receptor become to be a therapeutic target in Parkinson's disease therapy, and much more.
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Table of Contents
1. A2A Adenosine Receptor Agonists, Antagonists, Inverse Agonists and Partial Agonists
Kenneth A. Jacobson
2. Chemistry
agonists, antagonists, partial agonists, inverse agonists
Christa M�ller
3. Functional roles of adenosine receptors
biochemistry and neuronal plasticity
Ana Sebastiao
4. A2A and Depression
Rodrigo Cunha
5. A2AR and glial function
Zhihua Gao
6. The adenosine A2A receptor in the basal ganglia: expression in health and disease, heteromerization, functional selectivity and signalling
Rafael Franco, Gemma Navarro and Eva Martinez-Pinilla
7. How and why A2a receptor become to be a therapeutic target in Parkinson's disease therapy
Peter Jenner
8. Development of A2a antagonists for Parkinson's disease
clinical evaluation for motor and non-motor symptoms
Yasar Torres-Yaghi
9. The role of A2AR in chemobrain and the potential therapeutic benefits of istradefylline
Detlev Boison and Mi-hyeon Jang
10. Effects of adenosine A2A receptors on cognitive function in health and disease
Anna G. Orr, Cinthia Garcia and Avital Licht-Murava
11. A2a receptor and Sleep disturbance
Michael Lazarus and Mustafa Korkutata
12. Adenosine A2A signals and Dystonia
Makio Takahashi
13. Protective potential of caffeine and adenosine A2A adenosine receptor antagonism in LRRK2 Parkinson's disease
Michael Schwarzschild
14. A2a antagonists and Alzheimer's disease
David Blum
15. A2a receptors and ALS/MS
Zheng Wu
16. A2AR and trauma/PTSD
Yuanguo Zhou