Techniques for Downstream process for Biologic Drugs and Vaccines provides comprehensive technologies involved in processing postharvest broth to separate the target biological therapeutic products of extracellular or intercellular aspects in nature - to its highest purification form, and to thus make it acceptable to end users. The technologies involved in the post-harvesting of fermented broth are explained in this comprehensive resource in a simplified manner with different case studies to help non-engineering students and scientists easily capture the basic principle of biomass processing technologies and their applications in new projects related to the development and manufacturing of therapeutic bio-products.
As conceptual development of biotechnology has taken new shape and style with the integration of medical sciences, physical science, and engineering, and has thus begun the need for the development of microbial or cell line process technology and application for large-scale isolation and purification of metabolites or vaccines through the fermentation process, this book covers the most important aspects.
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Table of Contents
1. Pre-harvesting Conditions and Planning for Downstream Process2. Downstream Process (Harvested Broth Concentration Phase I3. Biomass Concentrations Phase II4. Release of Intracellular Materials Phase-III5. Extraction of Product of Interest Phase IV6. Viral Vectors for Vaccine Production7. Quality Control 8. Qualities by Design9. Towards Biologics
