The downstream processing market has grown rapidly in recent years. It will grow from $27.19 billion in 2023 to $31.07 billion in 2024 at a compound annual growth rate (CAGR) of 14.3%. The historical period's growth can be ascribed to the growth of biopharmaceutical investments, the enforcement of strict regulatory standards, the global expansion of biopharmaceutical production, and the escalating prevalence of chronic diseases.
The downstream processing market is poised for rapid expansion in the coming years, reaching $51.09 billion by 2028 with a compound annual growth rate (CAGR) of 13.2%. This projected growth in the forecast period is attributed to the increasing demand for biopharmaceuticals, a heightened focus on sustainable and eco-friendly processing, growing collaborations and partnerships, the sustained adoption of continuous bioprocessing, and an escalating demand for personalized medicines. Key trends anticipated in the forecast period include the integration of digitalization and Industry 4.0, technological advancements, the utilization of single-use systems, the expansion of the biopharmaceutical industry, and the widespread adoption of continuous processing.
The anticipated increase in healthcare expenditure is poised to be a driving force for the future expansion of the downstream processing market. Healthcare expenditure encompasses all spending related to health services, family planning activities, nutrition initiatives, and emergency aid specifically allocated for health-related purposes. This heightened expenditure is expected to bolster the sales of downstream processing, a pivotal component in extracting drug substances (DS) from natural sources such as bacterial or animal cells and subsequently purifying the drug substance. According to the 2021-2030 National Health Expenditure (NHE) report by the Centers for Medicare & Medicaid Services in the United States, as of March 2022, the annual increase in national health spending is projected to average 5.1% between 2021 and 2030, reaching an approximate total of $6.8 trillion by 2030. Over the same period, Medicare expenditures are expected to grow at a 7.2% annual rate, while Medicaid spending is projected to increase at a 5.6% annual rate. Thus, the escalating healthcare expenditure significantly contributes to the downstream processing market's growth.
The anticipated growth in the biopharmaceutical sector is expected to drive the future expansion of the downstream processing market. The biopharmaceutical sector, a segment of the pharmaceutical industry specializing in the development, manufacturing, and commercialization of drugs and therapies derived from biological sources, is set to increase the demand for downstream processing (DSP). DSP is a crucial stage in the biopharmaceutical manufacturing process, responsible for isolating, purifying, and concentrating the desired drug substance from the complex mixture obtained after upstream processing. For instance, in June 2023, the European Federation of Pharmaceutical Industries and Associations (EFPIA), a European trade association representing the pharmaceutical industry, reported that the total pharmaceutical production in Europe amounted to $384,200 million (€340,000 million) in 2022, reflecting an increase of approximately 4.95% from $366,267 million (€323,950 million) in 2021. Therefore, the rising demand in the biopharmaceutical sector is a key driver for the downstream processing market's growth.
A prominent trend gaining traction is the emphasis on product innovations. Leading companies in the market are dedicated to developing new technological solutions as part of their strategy to solidify their market presence. For example, in September 2022, Tosoh Bioscience LLC, a global chemical and specialty materials company based in the United States, introduced the Octave BIO Multi-Column Chromatography (MCC) system. This innovative system serves as a comprehensive solution for downstream process intensification, specifically designed for advanced biomolecule purification processes. Its modular design allows flexibility to accommodate diverse requirements, offering advantages such as resin and buffer cost savings.
A key focus of major companies in the downstream processing market is on pioneering solutions, including the implementation of flow cells to drive revenue growth. A flow cell is a specialized container designed for the continuous flow of liquid samples. For instance, in October 2023, SCHOTT AG, a Germany-based technology group specializing in specialty glass and glass-ceramics, launched ViewCell. This new component aims to facilitate safe and continuous process control, optimizing downstream operations in the biopharmaceutical industry. The flexibility provided by the viewcell flow cell is expected to enhance the efficiency of downstream processes in the biopharmaceutical industry.
In January 2023, Astea Bio separations, a UK-based provider of bioseparation and purification technologies, completed the acquisition of Delta Precision Ltd. for an undisclosed amount. This acquisition positions Astea Bio separations to strengthen its existing portfolio of bioprocessing resins, reusable columns, and prepacked single-use columns by incorporating a wide range of high-performance chromatography columns for biomanufacturing. Delta Precision Ltd., a UK-based manufacturer of advanced chromatography columns, produces products for various applications, including protein purification, vaccine production, and drug development.
Major companies operating in the downstream processing market report are Sartorius AG, General Electric Company, Merck KGaA, Thermo Fisher Scientific Inc., Danaher Corporation, Repligen Corporation, Minnesota Mining and Manufacturing Company, Lonza Group Ltd., Eppendorf AG, Corning Corporation, Ferner PLC, Ashai Kasei Corporation, Finesse Solutions Inc., MilliporeSigma, Illumina Inc., Pall Corporation, Bio-Rad Laboratories, Charles River Laboratories International Inc., Waters Corporation, Becton Dickinson and Company (BD), Entegris Inc., Novasep, Avantor Sciences, Tecan Group, Agilent Technologies, Bracco S.p.A., Boehringer Ingelheim International GmbH, Eisai Co. Ltd., Novo Nordisk A/S, Ahlstrom-Munksjö Oyj, Grifols S.A., GenScript Biotech Corporation.
North America was the largest region in the downstream processing market in 2023. Asia-Pacific is expected to be the fastest-growing region in the global downstream processing market report during the forecast period. The regions covered in the downstream processing market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the downstream processing market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
Key products utilized in downstream processing encompass centrifuges, dryers, chromatography systems, filters, evaporators, and others. Various techniques are applied, including purification methods, solid-liquid separation, and clarification or concentration. Centrifuges are devices that leverage centrifugal force to separate materials based on different densities, eliminate moisture, or replicate the effects of gravity. They find applications in diverse areas such as monoclonal antibody production, vaccine production, insulin production, immunoglobulin production, erythropoietin production, and more.
The downstream processing market research report provides downstream processing market statistics, including downstream processing industry global market size, regional shares, competitors with a downstream processing market share, detailed downstream processing market segments, market trends and opportunities, and any further data you may need to thrive in the downstream processing industry. This downstream processing market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The downstream processing market consists of revenues earned by entities by providing downstream processing services such as cell separation, filtration, product recovery, extraction of products, and more. The market value includes the value of related goods sold by the service provider or included within the service offering. The Downstream processing market also includes sales of small-scale fermenters, pilot-scale fermenters, centrifuges, and membrane filtration systems which are used in providing downstream processing services. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
This product will be delivered within 3-5 business days.
The downstream processing market is poised for rapid expansion in the coming years, reaching $51.09 billion by 2028 with a compound annual growth rate (CAGR) of 13.2%. This projected growth in the forecast period is attributed to the increasing demand for biopharmaceuticals, a heightened focus on sustainable and eco-friendly processing, growing collaborations and partnerships, the sustained adoption of continuous bioprocessing, and an escalating demand for personalized medicines. Key trends anticipated in the forecast period include the integration of digitalization and Industry 4.0, technological advancements, the utilization of single-use systems, the expansion of the biopharmaceutical industry, and the widespread adoption of continuous processing.
The anticipated increase in healthcare expenditure is poised to be a driving force for the future expansion of the downstream processing market. Healthcare expenditure encompasses all spending related to health services, family planning activities, nutrition initiatives, and emergency aid specifically allocated for health-related purposes. This heightened expenditure is expected to bolster the sales of downstream processing, a pivotal component in extracting drug substances (DS) from natural sources such as bacterial or animal cells and subsequently purifying the drug substance. According to the 2021-2030 National Health Expenditure (NHE) report by the Centers for Medicare & Medicaid Services in the United States, as of March 2022, the annual increase in national health spending is projected to average 5.1% between 2021 and 2030, reaching an approximate total of $6.8 trillion by 2030. Over the same period, Medicare expenditures are expected to grow at a 7.2% annual rate, while Medicaid spending is projected to increase at a 5.6% annual rate. Thus, the escalating healthcare expenditure significantly contributes to the downstream processing market's growth.
The anticipated growth in the biopharmaceutical sector is expected to drive the future expansion of the downstream processing market. The biopharmaceutical sector, a segment of the pharmaceutical industry specializing in the development, manufacturing, and commercialization of drugs and therapies derived from biological sources, is set to increase the demand for downstream processing (DSP). DSP is a crucial stage in the biopharmaceutical manufacturing process, responsible for isolating, purifying, and concentrating the desired drug substance from the complex mixture obtained after upstream processing. For instance, in June 2023, the European Federation of Pharmaceutical Industries and Associations (EFPIA), a European trade association representing the pharmaceutical industry, reported that the total pharmaceutical production in Europe amounted to $384,200 million (€340,000 million) in 2022, reflecting an increase of approximately 4.95% from $366,267 million (€323,950 million) in 2021. Therefore, the rising demand in the biopharmaceutical sector is a key driver for the downstream processing market's growth.
A prominent trend gaining traction is the emphasis on product innovations. Leading companies in the market are dedicated to developing new technological solutions as part of their strategy to solidify their market presence. For example, in September 2022, Tosoh Bioscience LLC, a global chemical and specialty materials company based in the United States, introduced the Octave BIO Multi-Column Chromatography (MCC) system. This innovative system serves as a comprehensive solution for downstream process intensification, specifically designed for advanced biomolecule purification processes. Its modular design allows flexibility to accommodate diverse requirements, offering advantages such as resin and buffer cost savings.
A key focus of major companies in the downstream processing market is on pioneering solutions, including the implementation of flow cells to drive revenue growth. A flow cell is a specialized container designed for the continuous flow of liquid samples. For instance, in October 2023, SCHOTT AG, a Germany-based technology group specializing in specialty glass and glass-ceramics, launched ViewCell. This new component aims to facilitate safe and continuous process control, optimizing downstream operations in the biopharmaceutical industry. The flexibility provided by the viewcell flow cell is expected to enhance the efficiency of downstream processes in the biopharmaceutical industry.
In January 2023, Astea Bio separations, a UK-based provider of bioseparation and purification technologies, completed the acquisition of Delta Precision Ltd. for an undisclosed amount. This acquisition positions Astea Bio separations to strengthen its existing portfolio of bioprocessing resins, reusable columns, and prepacked single-use columns by incorporating a wide range of high-performance chromatography columns for biomanufacturing. Delta Precision Ltd., a UK-based manufacturer of advanced chromatography columns, produces products for various applications, including protein purification, vaccine production, and drug development.
Major companies operating in the downstream processing market report are Sartorius AG, General Electric Company, Merck KGaA, Thermo Fisher Scientific Inc., Danaher Corporation, Repligen Corporation, Minnesota Mining and Manufacturing Company, Lonza Group Ltd., Eppendorf AG, Corning Corporation, Ferner PLC, Ashai Kasei Corporation, Finesse Solutions Inc., MilliporeSigma, Illumina Inc., Pall Corporation, Bio-Rad Laboratories, Charles River Laboratories International Inc., Waters Corporation, Becton Dickinson and Company (BD), Entegris Inc., Novasep, Avantor Sciences, Tecan Group, Agilent Technologies, Bracco S.p.A., Boehringer Ingelheim International GmbH, Eisai Co. Ltd., Novo Nordisk A/S, Ahlstrom-Munksjö Oyj, Grifols S.A., GenScript Biotech Corporation.
North America was the largest region in the downstream processing market in 2023. Asia-Pacific is expected to be the fastest-growing region in the global downstream processing market report during the forecast period. The regions covered in the downstream processing market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the downstream processing market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
Key products utilized in downstream processing encompass centrifuges, dryers, chromatography systems, filters, evaporators, and others. Various techniques are applied, including purification methods, solid-liquid separation, and clarification or concentration. Centrifuges are devices that leverage centrifugal force to separate materials based on different densities, eliminate moisture, or replicate the effects of gravity. They find applications in diverse areas such as monoclonal antibody production, vaccine production, insulin production, immunoglobulin production, erythropoietin production, and more.
The downstream processing market research report provides downstream processing market statistics, including downstream processing industry global market size, regional shares, competitors with a downstream processing market share, detailed downstream processing market segments, market trends and opportunities, and any further data you may need to thrive in the downstream processing industry. This downstream processing market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The downstream processing market consists of revenues earned by entities by providing downstream processing services such as cell separation, filtration, product recovery, extraction of products, and more. The market value includes the value of related goods sold by the service provider or included within the service offering. The Downstream processing market also includes sales of small-scale fermenters, pilot-scale fermenters, centrifuges, and membrane filtration systems which are used in providing downstream processing services. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
This product will be delivered within 3-5 business days.
Table of Contents
1. Executive Summary2. Downstream Processing Market Characteristics3. Downstream Processing Market Trends and Strategies31. Global Downstream Processing Market Competitive Benchmarking32. Global Downstream Processing Market Competitive Dashboard33. Key Mergers and Acquisitions in the Downstream Processing Market
4. Downstream Processing Market - Macro Economic Scenario
5. Global Downstream Processing Market Size and Growth
6. Downstream Processing Market Segmentation
7. Downstream Processing Market Regional and Country Analysis
8. Asia-Pacific Downstream Processing Market
9. China Downstream Processing Market
10. India Downstream Processing Market
11. Japan Downstream Processing Market
12. Australia Downstream Processing Market
13. Indonesia Downstream Processing Market
14. South Korea Downstream Processing Market
15. Western Europe Downstream Processing Market
16. UK Downstream Processing Market
17. Germany Downstream Processing Market
18. France Downstream Processing Market
19. Italy Downstream Processing Market
20. Spain Downstream Processing Market
21. Eastern Europe Downstream Processing Market
22. Russia Downstream Processing Market
23. North America Downstream Processing Market
24. USA Downstream Processing Market
25. Canada Downstream Processing Market
26. South America Downstream Processing Market
27. Brazil Downstream Processing Market
28. Middle East Downstream Processing Market
29. Africa Downstream Processing Market
30. Downstream Processing Market Competitive Landscape and Company Profiles
34. Downstream Processing Market Future Outlook and Potential Analysis
35. Appendix
Executive Summary
This report provides strategists, marketers and senior management with the critical information they need to assess the market.This report focuses on downstream processing market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
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Description
Where is the largest and fastest growing market for downstream processing? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? This report answers all these questions and many more.The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market’s historic and forecast market growth by geography.
Scope
Markets Covered:1) By Product: Centrifuges; Dryers; Chromatography Systems; Filters; Evaporators; Other Products
2) By Technique: Purification Techniques; Solid-Liquid Separation; Clarification Or Concentration
3) By Application: Monoclonal Antibody Production; Vaccine Production; Insulin Production; Immunoglobulin Production; Erythropoietin Production; Other Applications
Key Companies Mentioned: Sartorius AG; General Electric Company; Merck KGaA; Thermo Fisher Scientific Inc.; Danaher Corporation
Countries: Australia; Brazil; China; France; Germany; India; Indonesia; Japan; Russia; South Korea; UK; USA; Canada; Italy; Spain
Regions: Asia-Pacific; Western Europe; Eastern Europe; North America; South America; Middle East; Africa
Time Series: Five years historic and ten years forecast
Data: Ratios of market size and growth to related markets, GDP proportions, expenditure per capita
Data Segmentation: Country and regional historic and forecast data, market share of competitors, market segments
Sourcing and Referencing: Data and analysis throughout the report is sourced using end notes
Delivery Format: PDF, Word and Excel Data Dashboard
Companies Mentioned
- Sartorius AG
- General Electric Company
- Merck KGaA
- Thermo Fisher Scientific Inc.
- Danaher Corporation
- Repligen Corporation
- Minnesota Mining and Manufacturing Company
- Lonza Group Ltd.
- Eppendorf AG
- Corning Corporation
- Ferner PLC
- Ashai Kasei Corporation
- Finesse Solutions Inc.
- MilliporeSigma
- Illumina Inc.
- Pall Corporation
- Bio-Rad Laboratories
- Charles River Laboratories International Inc.
- Waters Corporation
- Becton Dickinson and Company (BD)
- Entegris Inc.
- Novasep
- Avantor Sciences
- Tecan Group
- Agilent Technologies
- Bracco S.p.A.
- Boehringer Ingelheim International GmbH
- Eisai Co. Ltd.
- Novo Nordisk A/S
- Ahlstrom-Munksjö Oyj
- Grifols S.A.
- GenScript Biotech Corporation
Methodology
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