Enables researchers to effectively understand and use bioactive compounds to target, prevent, and manage diabetes
Natural Products and Their Bioactives in Antidiabetic Drug Discovery provides readers with an overview of recent research in new drug discovery against diabetic complications based on bioactives from NPs, bridging the gap between the public research institutes and private companies working to find drugs to treat diabetes. To aid in reader comprehension, the text includes case studies and illustrated examples in relevant chapters.
Part one presents chapters on fundamental concepts of diabetes mellitus (DM) and recent drug discovery progress along with the various druggable targets and challenges. Part two covers bioactive compounds targeting Type-1 Diabetes. Part three focuses on Type-2 Diabetes. In Part four, the contributors address gestational DM prevention and management with natural compounds.
Written by a global team of experts in the field, Natural Products and their Bioactives in Antidiabetic Drug Discovery covers sample topics such as: - Obesity risk factor in patients with T1DM and possible role of nutritional therapy in its management - Use of natural non-insulin drugs as a novel approach to enhance therapeutic outcomes against T1DM - Effectiveness of functional foods in intervening the diabetic complications and realistic results in clinical trials - Implementation of nanotechnology in improving the bioavailability and reducing the threshold dose of bioactive compounds - Various antidiabetic mechanisms of action of different polyphenols and immunomodulatory role of NPs bioactives relevance in T1DM therapy - Effects of natural products on genetics of gestational diabetes
With comprehensive coverage of recent research in new drug discovery against diabetic complications based on bioactives from NPs, Natural Products and Their Bioactives in Antidiabetic Drug Discovery is an essential resource for researchers and professionals involved in drug discovery and development, health care, medicinal chemistry, phytochemistry, plant science, and toxicology.
Table of Contents
List of Contributors viii
Preface xii
Part I Fundamental Concepts of Diabetes Mellitus and Drug Discovery Process 1
1 Diabetes Mellitus and Natural Product-based Drug Discovery: Novel Directions 3
David J. Newman
2 Marine Natural Products in the Management of Diabetes Mellitus 18
Murali Krishna Paidi, Kanchan Siddaprasad Udata, and Subir Kumar Mandal
3 Carbohydrate-based Antidiabetic Agents from Natural Products 38
Sandeep Singh
4 Functional Foods in Clinical Trials in the Intervention of Diabetes Complications 49
Bavani Arumugam and Umah Rani Kuppusamy
5 Role of Nanotechnology in Refining the Antidiabetic Activities of Plant Derived Bioactives 74
Sonam Mishra, Ravindra Dhar, Maitree Suttajit, and Bishnu Kumar Pandey
Part II Bioactive Compounds Against Type 1 Diabetes Mellitus 97
6 Epidemiology and Genetics of Type 1 Diabetes Mellitus: The Effect of the Mediterranean Diet 99
Bilge Nur Col and Muveddet Emel Alphan
7 The Emerging Role of Plant Polyphenols in the Management of Type 1 Diabetes Mellitus 113
S. Asha Devi, Suparna Mandal, and S. Raja Sekhar
8 Bioactives as Modulators of β-cells and Immunity in Therapy of Type 1 Diabetes Mellitus 136
Shashank Kumar Ojha
9 Obesity in Type 1 Diabetes Mellitus: Clinical Impact and Nutritional Therapy 147
Gülen Ecem Kalkan and Burcu Ateş Özcan
10 Protective Effects of Natural Non-insulin Drugs against Type 1 Diabetes Mellitus 164
Waseem Hassan, Faraza Javaid, Andleeb Shahzadi, and Sahar Bakht
Part III Bioactive Compounds Against Type 2 Diabetes Mellitus 177
11 Age-induced Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus: Role of Plant Polyphenols 179
Brahm Kumar Tiwari and Kanti Bhooshan Pandey
12 Bioactives from Clove Oil for Antibacterial Wound Dressings for the Treatment and Management of Wounds in Type 2 Diabetes Mellitus 195
Andleeb Shahzadi and Haktan Sonmez
13 Nutritional Features and Bioactivities of Thymoquinone against Type 2 Diabetes Mellitus 211
Pınar Atukeren
14 Effect of Resveratrol and Catechins in Maintaining Redox Homeostasis during Type 2 Diabetes Mellitus 219
Prachee Dubey and Geeta Watal
15 Cannabis: Action Mechanisms and Potential Roles in the Management of Type 2 Diabetes Mellitus 232
Karolin Yanar and Zeynep Mine Coşkun Yazıcı
Part IV Gestational Diabetes: Prevention and Management by Natural Compounds 245
16 Epidemiology of Gestational Diabetes Mellitus: Preventive Significance of Dietary Pattern 247
Burcu Yeşilkaya
17 Biomarkers of Gestational Diabetes Mellitus, Dietary Polyphenols, and Drug Discovery 260
Mansi Gandhi
18 Medicinal and Aromatic Plants in the Prevention of Gestational Diabetes and Associated Consequences: Current Insights 275
Jigeesha Mishra, Kanti Bhooshan Pandey, and Shailendra Kumar Srivastava
19 Enhancement of Insulin Sensitivity and Management of Lipid Disorders during Gestational Diabetes Mellitus: Role of Capsaicin 294
Banu Orta-Yilmaz, Ahu Korkut, and Yasemin Aydin
20 Effects of Natural Products on the Genetics of Gestational Diabetes Mellitus 308
Onur Baykara
Index 321
