Practical Transfusion Medicine, Sixth Edition
The pace of change in transfusion medicine is relentless, with new scientific and technological developments and continuing efforts to improve transfusion practice. This sixth edition of Practical Transfusion Medicine has been updated significantly to reflect the rapid changes in transfusion medicine since the fifth edition was published in 2017.
The primary purpose of this edition remains the same as the first: to provide a comprehensive guide to transfusion medicine. This book contains more depth of information than standard handbooks on transfusion medicine, whilst being more concise and approachable than a standard reference text.
This book covers the principles of transfusion medicine, the complications of transfusion, practice in blood centres and hospitals and clinical transfusion practice. This sixth edition includes a new section on patient blood management, cellular and tissue therapy, organ transplantation and the development of the evidence base for transfusion. It also features a new chapter on transfusion-associated circulatory overload to underline its importance as a complication of transfusion, and a reconfiguration of the section on clinical transfusion practice to allow consideration of the transfusion management of medical, surgical and haematology patients with and without bleeding.
This sixth edition of Practical Transfusion Medicine provides accessible and comprehensive coverage of the field of transfusion medicine. It is a standalone text that will be useful to clinical and scientific staff: not only for trainees who require an overview of the field, but also for established practitioners who are involved in some aspect of transfusion medicine and require a comprehensive, accessible reference book.
Table of Contents
List of Contributors ix
Preface to the Sixth Edition xvi
1 Introduction: Two Centuries of Progress in Transfusion Medicine 1
Walter H. (Sunny) Dzik and Michael F. Murphy
Part I Basic Principles of Immunohaematology 11
2 Essential Immunology for Transfusion Medicine 11
Gregory A. Denomme
3 Human Blood Group Systems 21
Geoff Daniels and Sean Stowell
4 Human Leukocyte Antigens 33
H. Cliff Sullivan and Caroline R. Alquist
5 Platelet and Neutrophil Antigens 47
Brian R. Curtis
6 Pretransfusion Testing and the Selection of Red Cell Products for Transfusion 64
Mark H. Yazer, Meghan Delaney and Gregory A. Denomme Copyrighted Material
Part II Complications of Transfusions 77
7 Investigation of Acute Transfusion Reactions 77
Heather Leary, Kathryn E. Webert and Nancy M. Heddle
8 Haemolytic Transfusion Reactions 91
Edwin J. Massey, Robertson D. Davenport and Richard M. Kaufman
9 Febrile and Allergic Transfusion Reactions 108
Sarah K. Harm and Mark K. Fung
10 Transfusion- Associated Circulatory Overload 120
Robert B. Klanderman and Alexander P.J. Vlaar
11 Transfusion- Related Acute Lung Injury (TRALI) 130
Alexander P.J. Vlaar and Rick Kapur
12 Purported Adverse Effects of ‘Old Blood’ 145
Lirong Qu and Darrell J. Triulzi
13 Transfusion- Induced Immunomodulation 154
Neil Blumberg, Majed A. Refaai and Joanna M. Heal
14 Transfusion- Associated Graft- versus- Host Disease and Microchimerism 166
Alexandra Budhai, Richard O. Francis and Beth H. Shaz
15 Posttransfusion Purpura 181
Michael F. Murphy
16 Heparin- Induced Thrombocytopenia 187
Theodore E. Warkentin and Andreas Greinacher
17 Transfusion- Transmitted Infections 206
Steven J. Drews and Roger Y. Dodd
18 Bacterial Contamination 221
Sandra Ramírez- Arcos and Mindy Goldman
19 Emerging Infections and Transfusion Safety 229
Roger Y. Dodd
Part III Practice in Blood Centres and Hospitals 238
20 Regulatory Aspects of Blood Transfusion 238
Louis M. Katz, Peter Flanagan and William G. Murphy
21 The Role of Hemovigilance in Transfusion Safety 247
Katharine A. Downes and Barbee I. Whitaker
22 Donors and Blood Collection 257
Marc Germain and Pierre Tiberghien
23 Blood Donation Testing and the Safety of the Blood Supply 269
Mindy Goldman and Steven J. Drews
24 Production and Storage of Blood Components 278
Marissa Li, Rebecca Cardigan, Stephen Thomas and Ralph Vassallo
25 Blood Transfusion in Hospitals 290
Zoe K. McQuilten, Erica M. Wood, Mark H. Yazer and Michael F. Murphy
26 Disaster Preparedness 313
Heidi Doughty, Fateha Chowdhury and Richard Rackham
27 Blood Transfusion in a Global Context 324
David J. Roberts, Imelda Bates, Stephen P. Field, Aggrey Dhabangi, Jean Pierre Allain and Meghan Delaney
Part IV Clinical Transfusion Practice 337
28 Inherited and Acquired Disorders of Haemostasis 337
Irina Chibisov, Jansen Seheult and Franklin Bontempo
29 Point- of- Care Haemostasis Testing 353
Katrina M. Morgan, Matthew D. Neal, Louis Alarcon and Christine M. Leeper
30 Transfusion in Bleeding Patients 365
Aaron S. Hess, Lynn G. Stansbury and John R. Hess
31 Transfusion in Non- Bleeding Medical and Surgical Patients 374
Killian Donovan, Akshay Shah, Stuart McKechnie and Simon J. Stanworth
32 Transfusion in Malignant Haematological Disease 385
Lise J. Estcourt and Michael F. Murphy
33 Transfusion in Benign Haematological Disease 399
Eric Salazar and Christopher A. Tormey
34 Transfusion in Patients with Haemoglobinopathies 409
Yvette C. Tanhehco and Patricia A. Shi
35 Transfusing Neonates and Infants 417
Marianne E. Yee and Cassandra D. Josephson
36 Immunodeficiency and Immunoglobulin Therapy 426
Siraj A. Misbah
Part V Patient Blood Management 441
37 Development of a Patient Blood Management Programme 441
Jonathan H. Waters
38 Perioperative Patient Blood Management 451
Martin Shao Foong Chong, Martin Rooms, Ravishankar Rao Baikady and Toby Richards
39 Restrictive Transfusion Practice and How to Implement It 465
Marie A. Hollenhorst and Lawrence Tim Goodnough
40 Using Data to Support Patient Blood Management 476
Nadia B. Hensley, Sandaruwani Abeysiri and Steven M. Frank
Part VI Cellular Therapy and Transplantation 489
41 Regulation and Accreditation in Cellular Therapy 489
Julia Wolf, Zbigniew (Ziggy) M. Szczepiorkowski and James Griffin
42 Stem Cell Collection and Therapeutic Apheresis 504
Khaled El- Ghariani and Zbigniew (Ziggy) M. Szczepiorkowski
43 Haemopoietic Stem Cell Processing and Storage 519
Akash Gupta and Ronan Foley
44 Haematopoietic Cell Transplantation 531
Richard Salisbury, Yisu Gu, Rachael Hough and Robert D. Danby
45 CAR- T Cells and Recent Advances in Clinical Cellular Immunotherapy 543
Yisu Gu, Alex Rampotas, Connor Sweeney, David J. Roberts and Ronjon Chakraverty
46 Tissue Banking 554
Akila Chandrasekar, Richard Lomas and Paul Rooney
Part VII Development of the Evidence Base for Transfusion 561
47 Observational and Interventional Trials in Transfusion Medicine 561
Alan T. Tinmouth, Dean Fergusson and Paul C. Hébert
48 Getting the Most Out of the Evidence for Transfusion Medicine and Lessons from the COVID-19 Pandemic 576
Simon J. Stanworth, Susan J. Brunskill, Carolyn Dorée and Yulia Lin
49 A Primer on Biostatistics 590
Andrew W. Shih, Na Li, Celina Montemayor and Nancy M. Heddle
50 A Primer on Health Economics 609
Seema Kacker and Aaron A. R. Tobian
51 Scanning the Future of Transfusion Medicine 620
Jay E. Menitove, Paul M. Ness, Suzanne R. Thibodeaux and Edward L. Snyder
Index 632
