Overview of current research and technologies in nanomaterial science as applied to omics science at the single cell level
Impact of Engineered Nanomaterials in Genomics and Epigenomics is a comprehensive and authoritative compilation of the genetic processes and instructions that specifically direct individual genes to turn on or off, focusing on the developing technologies of engineering nanomaterials and their role in cell engineering which have become important research tools for pharmaceutical, biological, medical, and toxicological studies.
Combining state-of-the art information on the impact of engineered nanomaterials in genomics and epigenomics, from a range of internationally recognized investigators from around the world, this edited volume offers unique insights into the current trends and future directions of research in this scientific field.
Impact of Engineered Nanomaterials in Genomics and Epigenomics includes detailed information on sample topics such as: - Impact of engineered nanomaterials in genomics and epigenomics, including adverse impact on glucose energy metabolism - Toxicogenomics, toxicoepigenomics, genotoxicity and epigenotoxicity, and mechanisms of toxicogenomics and toxicoepigenomics - Adverse effects of engineered nanomaterials on human environment and metabolomics pathways leading to ecological toxicity - Meta-analysis methods to identify genomic toxicity mechanisms of engineered nanomaterials and biological effects of engineered nanomaterial exposure - Artificial intelligence and machine learning of single-cell transcriptomics of engineered nanoparticles and trends in plant nano-interaction to mitigate abiotic stresses
This comprehensive work is a valuable and excellent source of authoritative and up-to-date information for advanced students and researchers, toxicologists, the drug industry, risk assessors and regulators in academia, industry, and government, as well as for clinical scientists working in hospital and clinical environments.
Table of Contents
Contents
List of Contributors xv
Preface xix
Acknowledgments xxi
1 Impact of Engineered Nanomaterials in Genomics and Epigenomics 1
Saura C. Sahu Contents
Nanotechnology: A Technological Advancement of the Twenty-First Century 1
Genomics and Epigenomics 1
Beneficial Impacts of Engineered Nanomaterials on Human Life 2
Potential Adverse Health Effects of Engineered Nanomaterials 2
Conclusions 3
References 3
2 Molecular Impacts of Advanced Nanomaterials at Genomic and Epigenomic Levels 5
Kamran Shekh, Rais A Ansari, Yadollah Omidi, and Saghir A. Shakil
Introduction 5
Classification of NMs 6
Absorption and Distribution of NMs 6
Major Adverse Effects of NMs 8
Known Cellular and Nuclear Uptake Mechanisms for Nanoparticles 10
Epigenetic Mechanisms and the Effect of NMs 11
DNA Methylation 12
Genetic and Genomic Effects of NMs 20
Conclusion 25
References 26
3 Endocrine Disruptors: Genetic, Epigenetic, and Related Pathways 41
Rais A. Ansari, Saleh Alfuraih, Kamran Shekh, Yadollah Omidi, Saleem Javed, and Saghir A. Shakil
Introduction 41
Toxic Effects of EDCs on Wildlife and Humans 47
Effects During Development 48
Delayed Effects 48
Transgenerational Effects 49
Identification of EDC: Methods 49
Genetic Pathways 50
Phosphorylation-Mediated Signaling Pathways of Nuclear Receptors and Other Transcription Factors: Link to EDC 53
ER-Signaling Pathways 53
Xenoandrogens and Metabolic Syndrome 54
AR Signaling Pathways 54
Mechanism of ED 55
Methylation and Gene Regulation 55
Role of Noncoding RNAs 59
Transgenerational Inheritance of Epigenetics Induced by EDCs 59
Anti-Thyroids 60
Organotin 62
Epigenetic Effects of Organotin 63
TCDD and Related Compounds 63
TCDD and Genetic Response 64
TCDD-Mediated Epigenetic Response 65
Conclusions 65
References 66
4 Nanoplastics in Agroecosystem and Phytotoxicity: An Evaluation of Cytogenotoxicity and Epigenetic Regulation 83
Piyoosh Kumar Babele and Ravi Kant Bhatia
Introduction 83
Fate and Behavior of NPs in Agroecosystem and Soil Environment 85
Uptake and Accumulation of NPs in Plants 87
NPs and Phytotoxicity 88
Can NPs Cause Cytogenotoxicity and Dysregulate Epigenetic Markers in Plants? 89
NPs and Epigenetic Regulation 91
Conclusion and Perspectives 92
References 93
5 Metal Oxide Nanoparticles and Graphene-Based Nanomaterials: Genotoxic, Oxidative, and Epigenetic Effects 99
Delia Cavallo, Pieranna Chiarella, Anna Maria Fresegna, Aureliano Ciervo, Valentina Del Frate, and Cinzia Lucia Ursini
Introduction 99
Physicochemical Properties of NMs and Toxicity 100
Mechanism of NM Genotoxicity 101
Epigenetic Effects of Nanomaterials 102
Studies on Genotoxic and Oxidative Effects of Metal Oxides and Graphene-Based Nanomaterials 104
Graphene-Based NMs 120
Studies on Epigenetic Effects of Metal Oxides and Graphene-Based Nanomaterials 123
Studies on Workers - Genotoxic and Oxidative Effects of Occupational Exposure to Metal Oxides Nanoparticles, SiO2 NPs, and Graphene-Based Nanomaterials 127
Conclusions 132
References 132
6 Epigenotoxicity of Titanium Dioxide Nanoparticles 145
Carlos Wells, Marta Pogribna, Beverly Lyn-Cook, and George Hammons
Introduction 145
Cellular Uptake and Biodistribution 147
DNA Methylation and TiO2 Nanoparticles 151
Histone Modifications and TiO2 Nanoparticles 157
MicroRNAs and TiO2 Nanoparticles 161
Risk Assessment 167
Conclusion 173
Disclaimer 174
References 174
7 Toxicogenomics of Multi-Walled Carbon Nanotubes 187
Pius Joseph
Introduction 187
MWCNTs 188
Lung Injury 190
Inflammation 190
Oxidative Stress 192
Fibrosis 193
Mesothelioma 195
Lung Cancer 196
Genotoxicity 197
Toxicogenomics of ENMs 198
Transcriptomics - Technical Aspects 199
Toxicogenomics of MWCNTs - Animal Studies 201
Toxicogenomics of MWCNT - Human Studies 206
Disclaimer 207
References 207
8 Nano-Engineering in Traumatic Brain Injury 217
Najlaa Al-Thani, Mohammad Z. Haider , Maryam Al-Mansoob, Stuti Patel, Salma M.S. Ahmad, Firas Kobeissy, and Abdullah Shaito
Introduction 217
Nanoparticles in the Treatment of TBI 218
Conclusion 222
References 223
9 Application of Nanoemulsions in Food Industries: Recent Progress, Challenges, and Opportunities 229
Ramesh Chaudhari, Vishva Patel, and Ashutosh Kumar
Introduction 229
Components of Nanoemulsions 231
Approaches for Nanoemulsion Production 232
Applications of Food-Grade Nanoemulsions 235
Comparison of Nanoemulsion from Conventional Methods 241
Problems and Probable Solutions of Nanoemulsions 242
Future Trends and Challenges 243
Regulations and Safety Aspects 243
Conclusion 244
Conflict of Interest 245
Acknowledgments 245
References 245
10 Adverse Epigenetic Effects of Environmental Engineered Nanoparticles as Drug Carriers 251
Yingxue Zhang, Eid Alshammari, Nouran Yonis, and Zhe Yang
Introduction 251
ENP-Based Drug-Delivery Systems 252
Adverse Epigenetic Effects of ENPs 257
ENP-Induced Epigenetic Toxicity Likely Mediated by ROS 269
Conclusion 271
References 271
11 Engineered Nanoparticles Adversely Impact Glucose Energy Metabolism 283
Yingxue Zhang, Alexander Yang, and Zhe Yang
Introduction 283
Biological Toxicity of Engineered Nanoparticles 284
Engineered Nanoparticles Alter Glucose Metabolism 285
Engineered Nanoparticles Alter TCA Cycle 288
Engineered Nanoparticles Alter Oxidative Phosphorylation 289
Conclusion 291
References 291
12 Artificial Intelligence and Machine Learning of Single-Cell Transcriptomics of Engineered Nanoparticles 295
Alexander Yang, Yingxue Zhang, and Zhe Yang
Introduction 295
Impact of Nanoparticles on Single-Cell Transcriptomics and Response Heterogeneity 297
AI and ML in scRNA-Seq Data Analysis 301
Determining Cell Differentiation and Lineage Based on Single-Cell Entropy 303
Conclusion 304
References 305
13 Toxicogenomics and Toxicological Mechanisms of Engineered Nanomaterials 309
Eid Alshammari, Yingxue Zhang, Alexander Yang, and Zhe Yang
Introduction 309
Genomic Responses to ENMs 310
Transcriptomic Responses to ENMs 313
Conclusion 314
References 315
14 Carbon Nanotubes Alter Metabolomics Pathways Leading to Broad Ecological Toxicity 319
Nouran Yonis, Eid Alshammari, and Zhe Yang
Introduction 319
Biomedical Application and Toxicity of Carbon Nanotubes 321
Metabolomics Toxicity of Carbon Nanotubes 323
Conclusion 326
References 326
15 Assessment of the Biological Impact of Engineered Nanomaterials Using Mass Spectrometry-Based MultiOmics Approaches 331
Nicholas Day, Tong Zhang, Matthew J. Gaffrey, Brian D. Thrall, and Wei-Jun Qian
Introduction 331
Applications of MS for the Measurements of Proteins, PTMs, Lipids, and Metabolites 332
Multiomics Investigation of ENM Exposure to Microorganisms 335
Multiomics Investigation of ENM Exposure Using In Vitro Cell Culture Models 337
Multiomics Studies Reveal Organ-Specific Toxicity at the Organismal Level 340
Conclusions and Perspectives 344
Acknowledgments 347
Compliance with Ethical Standards 347
References 347
16 Current Scenario and Future Trends of Plant Nano-Interaction to Mitigate Abiotic Stresses: A Review 355
Farhat Yasmeen, Ghazala Mustafa, Hafiz Muhammad Jhanzab, and Setsuko Komatsu
Abbreviations 355
Introduction 355
Synthesis of Nanoparticles 356
Morphophysiological Effects of Nanoparticles on Plant 364
Molecular Mechanism Altered by Nanoparticles 370
Nanoparticles Interaction with Plants 374
Conclusion and Future Prospects 375
References 376
17 Latest Insights on Genomic and Epigenomic Mechanisms of Nanotoxicity 397
Vratko Himič, Nikolaos Syrmos, Gianfranco K.I. Ligarotti, and Mario Ganau
Introduction 397
Mechanisms of Genotoxicity 397
Genomic Consequences of ENM Exposure 400
A Primer on Epigenetic Processes 403
Epigenomic Consequences of ENM Exposure 404
Importance of Properties of ENMs 409
Future Perspectives 411
References 411
Index 419
