A complete guide to the diagnosis and management of cutaneous lymphomas and pseudolymphomas
Easily misdiagnosed as benign skin diseases, malignant cutaneous lymphomas can present a variety of challenges to trainees and practicing specialists alike. Skin Lymphoma: The Illustrated Guide has been designed to alleviate some of these difficulties, providing all those working in the dermatological field with a complete and easily consulted text on this potentially fatal cancer. Authored by renowned dermatopathologist Professor Lorenzo Cerroni, its exhaustive contents cover the clinical presentations and pathological correlates of cutaneous lymphomas in their various forms, alongside their prognoses and strategies for treatment.
This expanded fifth edition features a wealth of enhancements and additions, including new chapters, updated content, and more than 1,300 full-color illustrations. Revised to reflect the most recent World Health Organization (WHO) and European Organization for Research and Treatment of Cancer (EORTC) classifications, its cutting-edge approach to its subject incorporates the latest molecular data, alongside more familiar histopathological and clinical features. The book’s considerable scope has been broadened into new and groundbreaking areas, the details of which are explored in chapters discussing primary cutaneous acral CD8+ T-cell lymphoma, composite lymphomas, and non-neoplastic cutaneous signs of systemic lymphomas, as well as in new sections on previously unexamined entities such as implant-associated anaplastic large cell lymphoma.
- Fully updated with new genetic data and most recent WHO classifications
- Contains four newly written chapters
- Features unconventional presentation sections with commentary on diagnosis
- Includes more than 1,300 color illustrations
Skin Lymphoma: The Illustrated Guide is an indispensable resource forclinical dermatologists, dermatopathologists, and any other medical practitioners and trainees involved in the diagnosis and treatment of skin lymphomas.
Table of Contents
List of Teaching Cases xi
Preface xiii
Acknowledgments xv
1 Introduction 1
Section 1: Cutaneous NK/T‐Cell lymphomas
2 The ‘‘parapsoriases’’: A Riddle, Wrapped in a Mystery, Inside an Enigma 15
3 Mycosis Fungoides 23
4 Sézary Syndrome 113
5 Primary Cutaneous CD30+ Lymphoproliferative Disorders 133
Lymphomatoid Papulosis 134
Cutaneous Anaplastic Large Cell Lymphoma 150
“Borderline” Cases 167
Intralymphatic CD30+ Large T‐Cell Lymphoma 168
Implant‐Associated Anaplastic Large Cell Lymphoma 170
6 Subcutaneous Panniculitis‐like T‐cell Lymphoma 180
7 Aggressive Cutaneous Cytotoxic Lymphomas 195
Primary Cutaneous Aggressive Epidermotropic CD8+ Cytotoxic T‐Cell Lymphoma 196
Primary Cutaneous γ/δ T‐Cell Lymphoma 201
Cutaneous Extranodal NK/T‐Cell Lymphoma, Nasal Type 208
8 Cutaneous Peripheral T‐cell Lymphoma, Not Otherwise Specified (NOS) 219
9 Cutaneous CD4+ Small/Medium T‐cell Lymphoproliferative Disorder 228
10 Acral CD8+ Cutaneous T‐cell Lymphoma 235
11 Cutaneous Adult T‐cell Leukemia/Lymphoma 239
12 Other Cutaneous NK/T‐cell Lymphomas 243
Cutaneous Angioimmunoblastic T‐Cell Lymphoma 243
Hydroa Vacciniforme‐Like Lymphoproliferative Disorder 246
Severe Mosquito Bite Allergy 250
Section 2: Cutaneous B‐Cell lymphomas
13 Cutaneous Follicle Center Lymphoma 255
14 Cutaneous Marginal Zone Lymphoma (Cutaneous MALT Lymphoma) and Variants 274
Cutaneous Marginal Zone Lymphoma, Conventional Variant 276
Cutaneous Marginal Zone Lymphoma, Lymphoplasmacytic Variant 287
Cutaneous Marginal Zone Lymphoma, Plasmacytic Variant 290
Cutaneous Marginal Zone Lymphoma, Blastoid Variant 292
Cutaneous Amyloidoma 293
15 Cutaneous Diffuse Large B‐cell Lymphoma, Leg Type 299
16 Intravascular Large Cell Lymphomas 315
Intravascular Large B‐Cell Lymphoma 316
Intravascular Large NK/T‐Cell Lymphoma 321
17 Other Cutaneous B‐cell Lymphomas 326
Epstein-Barr Virus (EBV)‐Positive Cutaneous Diffuse Large B‐Cell Lymphoma, Not Otherwise Specified (NOS) 326
Specific Cutaneous Manifestations in Mantle Cell Lymphoma 329
Specific Cutaneous Manifestations in Extracavitary Primary Effusion Lymphoma 331
Specific Cutaneous Manifestations in Multiple Myeloma 334
Specific Cutaneous Manifestations in Burkitt Lymphoma 336
Cutaneous Lymphomatoid Granulomatosis 340
Cutaneous Plasmablastic Lymphoma 342
Cutaneous T‐Cell/Histiocyte‐Rich Large B‐Cell Lymphoma 344
Cutaneous Manifestations in Waldenstrom Macroglobulinemia 346
Epstein-Barr Virus (EBV)‐Associated Mucocutaneous Ulcers 347
Section 3: Cutaneous lymphomas in immunosuppressed individuals
18 Cutaneous Lymphomas in Immunosuppressed Individuals 357
Cutaneous Posttransplant Lymphoproliferative Disorders 358
Cutaneous Lymphomas in HIV‐Infected Individuals 365
Cutaneous Lymphoproliferative Disorders in Other Iatrogenic and Non‐Iatrogenic Immune Deficiencies 368
Section 4: Specific cutaneous manifestations of leukemias and of precursor hematologic neoplasms
19 Cutaneous Manifestations of B‐cell Chronic Lymphocytic Leukemia 379
Progression to Diffuse Large B‐Cell Lymphoma (Richter Syndrome) 385
20 Cutaneous Manifestations of Myelogenous Leukemia 390
Chronic Myeloid Leukemia 399
Myelodysplastic Syndromes 400
21 Blastic Plasmacytoid Dendritic Cell Neoplasm 407
Mature Plasmacytoid Dendritic Cell Proliferations Associated With Myeloid Neoplasms 415
22 Cutaneous Manifestations of Other Leukemias 419
T‐Cell Prolymphocytic Leukemia 419
Aggressive Natural Killer Cell Leukemia 421
Specific Skin Manifestations of Other Types of Leukemia 422
23 Cutaneous Lymphoblastic Lymphomas 424
Cutaneous B‐Lymphoblastic Lymphoma 424
Cutaneous T‐Lymphoblastic Lymphoma 428
Section 5: Cutaneous manifestations of other lymphomas and non‐neoplastic cutaneous signs of systemic lymphomas
24 Cutaneous Manifestations of Hodgkin Lymphoma 437
Primary Cutaneous Hodgkin Lymphoma 440
25 Cutaneous Composite Lymphomas 443
26 Nonneoplastic Cutaneous Signs of Systemic Lymphomas 450
Section 6: Cutaneous lymphomas in children and adolescents
27 Cutaneous Lymphomas in Children and Adolescents 463
Mycosis Fungoides 463
Sézary Syndrome 464
Lymphomatoid Papulosis 467
Cutaneous Anaplastic Large Cell Lymphoma 467
Subcutaneous Panniculitis‐Like T‐Cell Lymphoma 468
Primary Cutaneous Aggressive Epidermotropic CD8+ Cytotoxic T‐Cell Lymphoma 468
Primary Cutaneous γ/δ T‐Cell Lymphoma 468
Extranodal NK/T‐Cell Lymphoma, Nasal Type 468
Primary Cutaneous Peripheral T‐Cell Lymphoma, not Otherwise Specified (NOS) 468
Cutaneous CD4+ Small/Medium T‐Cell Lymphoproliferative Disorder 468
Cutaneous Angioimmunoblastic T‐Cell Lymphoma 468
Epstein-Barr Virus (EBV)‐Positive T‐Cell and NK‐Cell Lymphoproliferative Diseases of Childhood (Hydroa Vacciniforme‐Like Lymphoproliferative Disorder, Severe Mosquito Bite Allergy) 468
Adult T‐Cell Lymphoma/Leukemia 469
Acral CD8+ T‐Cell Lymphoma 469
Cutaneous Follicle Center Lymphoma 469
Cutaneous Marginal Zone Lymphoma (Cutaneous MALT Lymphoma) 469
Cutaneous Burkitt Lymphoma 469
Cutaneous Intravascular Large Cell Lymphoma 469
Cutaneous Lymphomatoid Granulomatosis 469
EBV+ Mucocutaneous Ulcer 469
Cutaneous Lymphomas in Immunosuppressed Children and Adolescents 469
Cutaneous Manifestations of Myelogenous Leukemia 469
Blastic Plasmacytoid Dendritic Cell Neoplasm 470
Cutaneous Lymphoblastic Lymphoma (B or T Cell) 470
Section 7: Pseudolymphomas of the skin
28 Pseudolymphomas of the Skin 475
Chronic Actinic Dermatitis (Actinic Reticuloid) 477
Lymphomatoid Contact Dermatitis 478
Non‐mycosis Fungoides‐associated Follicular Mucinosis and Other Mimickers of Pilotropic Mycosis Fungoides 479
Solitary Idiopathic B/T‐cell Pseudolymphoma 481
Lichenoid (Lymphomatoid) Keratosis 483
T‐cell‐Rich Angiomatoid Polypoid Pseudolymphoma/ Acral Pseudolymphomatous Angiokeratoma in Children/ Pretibial Lymphoplasmacytic Plaque in Children (“T/B‐cell Angiomatoid Pseudolymphoma”) 486
Lichen Aureus/Lichenoid Pigmented Purpuric Dermatitis 487
Lichen Sclerosus 489
Vitiligo 489
Annular Lichenoid Dermatitis of Youth 490
Pseudolymphomatous Acrodermatitis Chronica Atrophicans 493
Pseudolymphomatous Atopic Dermatitis 495
Nonneoplastic Erythroderma in Adult Patients 496
Pseudolymphomatous Cutaneous Infiltrates in Human Immunodeficiency Virus (HIV)‐Infected Patients and in Other Immune Deficiencies 499
CD30+ T‐cell Pseudolymphomas 502
Persistent Nodular Arthropod Bite Reactions and Nodular Scabies 502
Pseudolymphomas in Herpes Simplex and Herpes Zoster Infections 504
Hydroa Vacciniforme 506
Pityriasis Lichenoides 507
Pseudolymphomas Associated with Lupus Erythematosus 511
Lymphomatoid Drug Reactions 515
Lymphocytoma Cutis 516
Lymphocytoma Cutis Associated with Borrelia Infection 518
Pseudolymphomas at Sites of Vaccination 522
Pseudolymphomas in Tattoos 524
Localized Scleroderma/Morphea 524
Cutaneous IgG4‐Related Disease 526
Pseudolymphomas in Syphilis 529
Cutaneous Plasma Cell Granuloma 534
Cutaneous and Systemic Plasmacytosis 535
Cutaneous Manifestations of Castleman Disease 536
Cutaneous Extramedullary Hematopoiesis 537
Histiocytoid Sweet Syndrome 538
Intralymphatic Histiocytosis 539
Benign Intralymphatic Proliferation of T‐cell Lymphoid Blasts 541
Other “Accidental” Pseudolymphomas 543
“Malignant” Pseudolymphomas 546
Section 8: The cutaneous “atypical lymphoid proliferation”
29 The Cutaneous “Atypical Lymphoid Proliferation” 565
Index 569
