This book helps readers move from fundamental organic chemistry principles to a deeper understanding of reaction mechanisms. It directly relates sophisticated mechanistic theories to synthetic and biological applications and is a practical, student-friendly textbook.
- Presents material in a student-friendly way by beginning each chapter with a brief review of basic organic chemistry, followed by in-depth discussion of certain mechanisms
- Includes end-of-chapter questions in the book and offers an online solutions manual along with PowerPoint lecture slides for adopting instructors
- Adds more examples of biological applications appealing to the fundamental organic mechanisms
Table of Contents
Preface xv
First Edition Preface xvii
1 Fundamental Principles 1
2 The Aliphatic C─H Bond Functionalization 53
3 Functionalization of the Alkene C=C Bond by Electrophilic Additions 95
4 Functionalization of the Alkene C=C Bond by Cycloaddition Reactions 143
5 The Aromatic C─H Bond Functionalization and Related Reactions 199
6 Nucleophilic Substitutions on sp3-Hybridized Carbons: Functional Group Transformations 257
7 Eliminations 317
8 Nucleophilic Additions and Substitutions on Carbonyl Groups 367
9 Reactivity of the α-Hydrogen to Carbonyl Groups 417
10 Rearrangements 457
Index 493
