Explore this practical and step-by-step guide to managing liver transplant patients from leading international clinicians in Hepatology
The newly revised Second Edition of Liver Transplantation: Clinical Assessment and Management delivers expert clinical guidance on best practices in managing the care of liver transplant patients. Authors are all experts in their field and cover a world-wide perspective. Organized in an accessible, stepwise fashion and packed with text features such as key points, the book covers all critical areas of each stage of the liver transplant journey, from assessment, to management on the list, to long term care.
Readers will learn when to refer a patient for liver transplantation, how to assess a potential liver transplant recipient, learn the principles of the procedure and the long term management of the transplant recipient. Liver Transplantation provides the entire hepatology and surgical team the information required for a sound understanding of the entire procedure, from pre- to post-operative care and management.
Clinically oriented and management-focused, the book is far more accessible than the liver transplant sections in traditional hepatology textbooks. Readers will also enjoy:
- A thorough discussion of when to refer a patient for liver transplantation, including general considerations and the use and abuse of prognostic models
- An exploration of the selection, assessment, and management of patients on the transplant list, including how to manage a patient with chronic liver disease while on the waiting list
- A treatment of liver transplantation for acute liver failure (ALF), including assessment and management of ALF patients on the transplant waiting list
- A discussion of care of the liver transplant recipient after the procedure in the short and long term
Perfect for gastroenterologists, hepatologists, and surgeons and other health care professionals managing patients with liver disease who are awaiting, undergoing and following liver transplantation, Liver Transplantation: Clinical Assessment and Management will also earn a place in the libraries of medical students, residents, internal medicine physicians, and GI/Hepatology trainees and all health care professionals providing clinical care to people with liver disease, before, during and after transplantation.
Table of Contents
List of Contributors x
Foreword to the Second Edition xx
Foreword to the First Edition xxi
Preface xxii
Abbreviations xxiii
Part 1 When to Refer a Patient for Liver Transplantation 1
1 Overview on Organ Donation and Liver Transplantation 3
Michael Ronan Lucey
2 Predicting Outcomes and Use and Abuse of Prognostic Models 11
Moira B. Hilscher and Patrick S. Kamath
Part 2 Selection, Assessment, and Management on the List 19
3 Assessment of the Potential Transplant Recipient 21
Michael L. Volk
4 Frailty and the Potential Liver Transplant Candidate 27
Matthew J. Armstrong and Jennifer C. Lai
5 Alcohol Use (excluding Alcohol-Related Liver Disease), Tobacco, Marijuana, and Illicit Drugs 33
John P. Rice
6 The Role of the Psychiatric Consultant in the Selection, Assessment, and Management of Liver Transplant Patients 39
Robert M. Weinrieb and Arpita Goswami-Banerjee
7 When Liver Transplant Patients Do Not Adhere to Therapeutic Plans 48
Kerry Webb and Rowena Jones
8 Liver Transplant Assessment for Young People: Addressing the Needs of Young People with Liver Disease 55
Marianne Samyn and Jemma Marie Day
9 Assessment and Management of the Patient with Hepatitis C 64
Emma L. Hathorn and David J. Mutimer
10 Management of Hepatitis B Virus Infection Pre Transplantation 68
Bruno Roche and Didier Samuel
11 Transplantation for the Management of Malignancy 74
Adiba I. Azad, Julie K. Heimbach, and Gregory J. Gores
12 Assessment and Management of the Liver Transplant Candidate with Acute-on-Chronic Liver Failure 82
Giovanni Perricone and Rajiv Jalan
13 Assessment and Management of the Transplant Candidate with Alcohol-Associated Liver Disease 96
Stéphanie Faure, Magdalena Meszaros, Lucy Meunier, Hélène Donnadieu-Rigole, and Georges-Philippe Pageaux
14 Non-alcoholic Fatty Liver Disease as an Indication for Liver Transplantation 104
Paul Horn and Philip N. Newsome
15 Consent 109
Christopher J.E. Watson
16 Prehabilitation and General Management 116
Matthew J. Armstrong and Felicity R. Williams
17 Removal of Patients from the Liver Transplant Waiting List 123
John O’Grady
18 Palliative Care and Liver Transplantation 126
Mina Rakoski and Puneeta Tandon
Part 3 Transplantation for Acute Liver Failure 135
19 Assessment of the Patient with Acute Liver Failure 137
Ashley Barnabas and John O’Grady
20 Management of the Patient with Fulminant Hepatic Failure Awaiting Liver Transplantation 143
Robert J. Fontana
Part 4 Donation and Allocation 153
21 Ethical and Legal Aspects of Organ Donation 155
Jessica Mellinger
22 Liver Allocation, Including Principles of Organ Allocation 161
Parita Patel and Michael Charlton
23 Living Donor Liver Transplant in Children 168
Adebowale A. Adeyemi, Elizabeth B. Rand, and Kim M. Olthoff
24 Living Liver Donation in Adults 180
Mohamed Rela and Ashwin Rammohan
25 Deceased Liver Donors: Standard and Expanded Criteria 190
Shareef Syed and Sandy Feng
26 Donor-Transmitted Disease 203
James Neuberger
27 Liver Donation and Preservation 209
Navneet Tiwari and Hynek Mergental
28 Liver Retrieval and Preservation 223
Carlo D.L. Ceresa, Brian R. Davidson, Peter J. Friend, and Rutger J. Ploeg
29 Alternatives to Whole Graft Liver Transplantation 236
Paolo Muiesan, Alessandro Parente, and Hector Vilca-Melendez
30 Surgical Aspects of Deceased Donor Transplantation 252
Amit Nair, K.V. Narayanan Menon, Cristiano Quintini, and Charles Miller
Part 5 Care of the Liver Transplant Recipient 265
31 Outcomes after Liver Transplantation 267
James Neuberger
32 Outpatient Follow-Up of Liver Transplant Recipients 276
Amardeep Khanna and James Ferguson
33 Medication Adherence 285
Maureen Whitsett and Josh Levitsky
34 Transitional Care 299
Fiona Thompson
35 Managing the Liver Transplant Recipient with Abnormal Liver Blood Tests 303
Joanna A. Leithead
36 The Immune System in Liver Transplantation: Rejection versus Tolerance 317
Palak J. Trivedi and Nick D. Jones
37 Immunosuppressive Medications: Liver Transplantation 334
Tim Mitchell and Gerry MacQuillan
38 Immunosuppression in Liver Transplantation 344
Nicholas Lim and John R. Lake
39 Patterns of Liver Allograft Rejection 353
Geoffrey W. McCaughan, Ken Liu, Avik Majumdar, Patrick Bertolino, David G. Bowen, and Simone I. Strasser
40 De Novo Autoimmune Hepatitis 360
James Neuberger
41 Managing Rejection 364
Neil Halliday and Douglas Thorburn
42 Withdrawal of Immunosuppression after Liver Transplantation 386
Luca Toti, Tommaso Maria Manzia, Francesca Blasi, and Giuseppe Tisone
43 Liver Transplant Pathology 393
Owen L. Cain and Stefan G. Hübscher
44 Care of the Liver Transplant Recipient: Management of Renal Function 403
Andres F. Carrion and Paul Martin
45 Managing Cardiovascular Risk in the Liver Transplant Recipient 409
Manhal Izzy and Kymberly D. Watt
46 Bone Disease in Liver Transplantation 418
John Ayuk
47 Diagnosis and Management of Recurrent Autoimmune Liver Disease 424
Fernanda Q. Onofrio, Nazia Selzner, and Gideon M. Hirschfield
48 NAFLD and NASH in the Patient after Liver Transplantation 438
Paul Horn and Philip N. Newsome
49 Recurrent Metabolic Diseases 445
James Neuberger
50 Treatment of Hepatitis C in the Transplant Setting 449
Jeffrey Kahn and Norah A. Terrault
51 Management of Hepatitis B Virus Infection Post Transplantation 458
Bruno Roche and Didier Samuel
52 Antimicrobial Prophylaxis Following Liver Transplantation 469
Michael J. Williams and Peter C. Hayes
53 Cytomegalovirus and the Liver Transplant Recipient 475
James Ferguson
54 Post-Liver Transplant Infections 481
Miruna David and Ahmed Elsharkawy
55 De Novo Malignancies after Liver Transplantation 493
Simone I. Strasser, Ken Liu, Avik Majumdar, and Geoffrey W. McCaughan
56 Post-Transplant Lymphoproliferative Disorders 500
Jose Ignacio Herrero
57 Quality of Life and Employment after Liver Transplantation 507
Santiago Tome, Esteban Otero, and Michael Ronan Lucey
58 Sexual Function, Fertility, and Pregnancy in Liver Disease and after Liver Transplantation 514
Patrizia Burra, Salvatore Stefano Sciarrone, and Patrizio Bo
59 Common Drug Interactions 519
Amanda Smith
60 Immunization and Liver Transplantation 525
Jessica Hause and Erin Spengler
Postscript 529
James Neuberger
Index 531
