Drug transporter fundamentals and relevant principles and techniques, featuring new and expanded chapters
Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques.
The updated and expanded third edition includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases. - Reflects the current state of the field and offers perspectives on future directions - Covers basic knowledge, clinical outcomes, and emerging discoveries in transporter science - Provides up-to-date information on drug transporter families, mechanisms, and clinical implications - Includes extensive references and numerous figures and tables throughout
Understandable for novices while offering sufficient depth for more experienced researchers, Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition is an excellent textbook for pharmacological or physiological science courses in drug/membrane transport, and an invaluable reference for academic or industrial scientists working in the transporter field and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics.
Table of Contents
List of Contributors
Preface
CHAPTER 1. Overview of Drug Transporter Families
Guofeng You and Marilyn E. Morris
CHAPTER 2. Organic Cation and Zwitterion Transporters
Megan L. Koleske, Xiaomin Liang, Osatohanmwen Jessica Enogieru, Dina Buitrago, and KathleenM. Giacomini
CHAPTER 3. Multidrug and Toxin Extrusion Proteins
Lauren M. Aleksunes, Victoria Woo, and Melanie S. Joy
CHAPTER 4. Organic Anion Transporters (OATs)
Jeffry C. Granados, Jingui Zhang, Guofeng You, Sanjay K. Nigam
CHAPTER 5. Organic Anion Transporting Polypeptides OATP
Rommel G. Tirona and Richard B. Kim
CHAPTER 6. Mammalian Oligopeptide Transporters
Stephen M. Carl, Dea Herrera-Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson, Stephanie Mowery, and Gregory T. Knipp.
CHAPTER 7. Monocarboxylic Acid Transporters
Marilyn E. Morris and Nisha V. Kwatra
CHAPTER 8. The Nucleoside Transporters CNTs and ENTs
Raj Govindarajan, Antonio López Quiñones, and Joanne Wang
CHAPTER 9. Bile Acid Transporters
Ebehiremen N. Ayewoh and Peter W. Swaan
CHAPTER 10. The P-glycoprotein Multidrug Transporter
Andaleeb Sajid, Sabrina Lusvarghi and Suresh V. Ambudkar
CHAPTER 11. Multidrug Resistance Proteins of the ABCC Subfamily
Anne T. Nies and Franziska Klein
CHAPTER 12. ABCG2, the Breast Cancer Resistance Protein (BCRP)
Robert W. Robey, Sabrina Lusvarghi, Cindy H. Chau, Agnes Basseville, William D. Figg, Suresh V. Ambudkar, and Susan E. Bates
CHAPTER 13. Drug Transport in the Liver
Noora Sjöstedt, Jeffry Adiwidjaja, William A. Murphy, and Kim L.R. Brouwer
CHAPTER 14. Drug Transport in the Brain
Vishal Sangha, Erica I. Williams, Patrick T. Ronaldson, and Reina Bendayan
CHAPTER 15. Drug Transport in the Kidney
Douglas H. Sweet
CHAPTER 16. Drug transporters in the human intestine
Stefan Oswald
CHAPTER 17. Drug Transport in the Placenta
Qingcheng Mao, Vadivel Ganapathy, and Jashvant D. Unadkat
CHAPTER 18. Polymorphisms of drug transporters and clinical relevance
Tore B. Stage and Deanna L. Kroetz
CHAPTER 19. Ontogeny of Drug Transporters
Melanie A. Felmlee and Qing Zhang
CHAPTER 20. Experimental Approaches for Studying Drug Transporters
Yusuke Masuo, Azusa Futatsugi, and Yukio Kato
CHAPTER 21. Transporters mediated drug disposition - Physiochemistry and in silico approaches
Manthena V. S. Varma, Ayman El-Kattan, and Yurong Lai
CHAPTER 22. In vitro-in vivo scale-up of drug transport activities
Kazuya Maeda and Yuichi Sugiyama
CHAPTER 23. Application of Physiologically Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Modeling Comprising Transporters: Delineating the Role of Various Factors in Drug Disposition and Toxicity
Matthew D. Harwood, Amin Rostami-Hodjegan, and Sibylle Neuhoff
CHAPTER 24. Transporters as therapeutic targets in human diseases
Robert S. Jones and Eugene C. Chen
CHAPTER 25. Diet/Nutrient Interactions with Drug Transporters
Marilyn E. Morris and Tianjing Ren
Index
