Organic Chemistry, 13th edition provides a comprehensive, yet accessible, treatment of all the essential organic chemistry concepts, with emphasis on relationship between structure and reactivity in the subject. The textbook includes all the concepts covered in a typical organic chemistry textbook but is unique in its skill-development approach to the subject. Numerous hands-on activities and real-world examples are integrated throughout the text to help students understand both the "why" and the "how" behind organic chemistry.
This International Adaptation offers new and updated content with improved presentation of all course material. It offers new material on several topics, including the relevance of intermolecular forces in the immune response and vaccines like those for Covid-19, the chemistry of breathing (carbonic anhydrase), how conjugation and complexation affect the color of lobsters, and how biodegradable polymers are used to stabilize vaccines and pharmaceuticals. Content is revised to reflect the current understanding of chemical processes, and improved depictions of longstanding mechanisms. This edition builds on the ongoing pedagogical strength of the book with the inclusion of additional worked and end-of-chapter problems and an engaging set of new problems entitled "Chemical Consultant Needed". These draw from the primary chemical literature and give students experience of working with more complex, polyfunctional structures, and areas where key transformations take place.
Table of Contents
1 The Basics: Bonding and Molecular Structure 1
2 Families of Carbon Compounds: Functional Groups, Intermolecular Forces, and Infrared (IR) Spectroscopy 53
3 An Introduction to Organic Reactions and Their Mechanisms: Acids and Bases 105
4 Nomenclature and Conformations of Alkanes and Cycloalkanes 147
5 Stereochemistry: Chiral Molecules 197
6 Nucleophilic Reactions: Properties and Substitution Reactions of Alkyl Halides 243
7 Alkenes and Alkynes I: Properties and Synthesis. Elimination Reactions of Alkyl Halides 285
8 Alkenes and Alkynes II: Addition and Oxidation Reactions 341
9 Nuclear Magnetic Resonance and Mass Spectrometry: Tools for Structure Determination 397
10 Radical Reactions 453
11 Alcohols and Ethers: Synthesis and Reactions 493
12 Alcohols from Carbonyl Compounds: Oxidation-Reduction and Organometallic Compounds 541
13 Conjugated Unsaturated Systems 579
14 Aromatic Compounds 627
15 Reactions of Aromatic Compounds 669
16 Aldehydes and Ketones: Nucleophilic Addition to the Carbonyl Group 723
17 Carboxylic Acids and Their Derivatives: Nucleophilic Addition-Elimination at the Acyl Carbon 773
18 Reactions at the α Carbon of Carbonyl Compounds: Enols and Enolates 825
19 Condensation and Conjugate Addition Reactions of Carbonyl Compounds: More Chemistry of Enolates 861
20 Amines 903
21 Transition Metal Complexes: Promoters of Key Bond-Forming Reactions 951
22 Carbohydrates 979
23 Lipids 1027
24 Amino Acids and Proteins 1063
25 Nucleic Acids and Protein Synthesis 1109
Glossary Gl- 1
Index I- 1
