A guide to recent insights into the genetic and epigenetic parameters of cancer biology and pathology and emerging clinical applications
The thoroughly updated second edition of The Biology and Treatment of Cancer, now titled Cancer: Prevention, Early Detection, Treatment and Recovery, goes beyond reviewing the fundamental properties of cancer biology and the relevant issues associated with treatment of the disease. The new edition contains coverage of additional "patient centric" topics and presents cancer biology with selection of topics, facts, and perspectives written in easy-to-understand terms.
With contributions from noted experts, the book explores recent advances in the understanding of cancer including breakthroughs in the molecular and cellular basis of cancer and provides strategies for approaching cancer prevention, early detection, and treatment. The authors incorporate recent information on the genetic and epigenetic parameters of cancer biology and pathology with indications of emerging clinical applications. The text offers a unique guide to cancer prevention, early detection, treatment, and recovery for students, caregivers, and most importantly cancer patients. This significant book:
- Incorporates current insight into the genetic and epigenetic parameters of cancer biology and pathology and information on emerging clinical applications
- Contains contributions from leaders in cancer research, care, and clinical trials
- Offers an accessible guide to an accurate and balanced understanding of cancer and the cancer patient
- Focuses on the importance of cancer prevention, early detection, treatment, and survivorship
Written for medical students, students of cancer biology, and caregivers and cancer patients, Cancer: Prevention, Early Detection, Treatment and Recovery offers an authoritative overview of the challenges and opportunities associated with cancer biology, cancer research, and the spectrum of clinical considerations.
Table of Contents
List of Contributors ix
Preface xv
Part I: Cancer and the Cancer Experience 1
1 Cancer and the Cancer Experience 3
Gary S. Stein and Kimberly P. Luebbers
Part II: Current Understanding of Cancer Biology 13
2 Cancer Biology and Pathology 15
G. Premveer Reddy, Lekkala V. Reddy, and Sahn‐Ho Kim
3 Causes of Cancer: Genetic, Epigenetic, Viral, Microenvironmental, and Environmental Contributions to Cancer 53
Michaela Reagan
Part III: A Cancer Diagnosis 75
4 Early Warning Signs 77
Solomon A. Graf and F. Marc Stewart
5 Importance of Imaging for Diagnosis and Treatment of Cancer 89
Kristin DeStigter, Sally Herschorn, Anant Bhave, Benjamin Lange, and Sean Reynolds
6 Cancer Biomarkers 107
Robert H. Getzenberg
7 Molecular Diagnosis 123
Mark F. Evans
Part IV: Navigating the Cancer Experience 145
8 Navigating the Cancer Experience 147
David C. Nalepinski
Part V: Clinical Dimensions to Cancer 167
9 Classification of Tumors, Their Frequency and Progression 169
Richard C. Zieren, Liang Dong, Sarah R. Amend, and Kenneth J. Pienta
10 Cancer Epidemiology: Identifying Cancer Risk 213
Bernard F. Cole, Brian L. Sprague, Thomas P. Ahern, and Judy R. Rees
Part VI: Tumor Types 227
11 Breast Cancer: Unique Characteristics as Targets for Therapy 229
Ogheneruona Apoe, Ted James, Gabriella Szalayova, Amrita Pandit, and Marie E. Wood
12 Prostate Cancer 245
David W. Sobel and Mark K. Plante
13 Gastrointestinal Cancer 259
Kristina Guyton, Baddr Shakhsheer, and Neil Hyman
14 Lung Cancer 271
Farrah B. Khan, C. Matthew Kinsey, and Garth Garrison
15 Pediatric Oncology 285
Jessica L. Heath
16 Leukemia, Lymphoma, and Myeloma 299
Alan Rosmarin
17 GU Oncology: Kidney, Urothelial, and Penile Cancer 317
Scott Perrapato
18 Liver Cancer: Hepatocellular Carcinoma 327
Jennifer LaFemina, Bradley Switzer, and Giles F. Whalen
19 GYN Oncology: Unique Characteristic Targets for Therapy in Gynecologic Cancers 345
Celeste Straight, Leslie Bradford, and Susan Zweizig
20 Testicular Cancer 365
Christopher B. Allard and Michael L. Blute
21 Head and Neck Cancer 379
Kumar G. Prasad, Marion Couch, and Michael Moore
22 Brain and Spinal Cord Tumors 395
Lawrence Recht
23 Thyroid Cancer 415
Frances E. Carr
Part VII: Treatment Options 445
24 Radiation Therapy 447
Thomas J. FitzGerald, Maryann Bishop‐Jodoin, Fran Laurie, Christopher Riberdy, Jesse N. Aronowitz, Elizabeth Bannon, Bruce A. Bornstein, Carla D. Bradford, Harry Bushe, Maria G. Cicchetti, Linda Ding, Jonathan M. Glanzman, David J. Goff, Beth B. Herrick, Jessica R. Hiatt, I‐Lin Kuo, Yuan‐Chyuan Lo, Janaki Moni, Richard S. Pieters, Paul S. Rava, Allison Sacher, Jonathan Saleeby, Shirin Sioshansi, Kenneth Ulin, John M. Varlotto, and Tao Wang
25 Radiation Therapy - The Patient Experience 463
Harold James Wallace, III
26 Pain Management in Cancer 481
Carlos A. Pino
27 Complementary and Alternative Medicine 499
Phil Trabulsy
28 Gene Therapy 531
Mai K. ElMallah, Michael Kalfopolous, and Terence R. Flotte
Part VIII: Patient Resources 553
29 Cancer‐Center‐Based Care 555
George J. Weiner
30 Supportive Care 563
Kathleen McBeth
31 Investigating Cancer Sentiments across Social Media 573
Eric M. Clark, W. Christian Crannell, Jesse Moore, Ted James, Mitchell Norotsky, and Chris A. Jones
Part IX: The Path to Reducing the Cancer Burden: Prevention, Early Detection, Recovery, Survivorship 591
32 Cancer Genetics: Risk Assessment 593
Wendy McKinnon
33 Cancer Prevention: Diet, Nutrition, and Lifestyle 603
Jennifer L. May and Jean R. Harvey
34 Cancer Survivorship 617
David Cranmer
35 The Tools of Advocacy in Cancer Prevention, Early Detection, Recovery, and Treatment 621
Jill Sudhoff‐Guerin
Index 637
