Probiotics have been suggested to be involved in both prevention and treatment of various human cancers. Anticancer Immunity: Reviewing the Potential of Probiotics explains biochemical mechanisms of anticancer immunity exerted by probiotics in various human cancers. It presents edited chapters focused on the evidence of probiotic use against human cancers through several animal and human studies.
This volume consists of 11 chapters. The volume continues from the previous entry with chapters focused on probiotics’ anticancer immunity in specific cancers such as, bladder cancer, renal cell carcinoma, prostate cancer, lymphomas, pancreatic cancer, oral cancer and oropharyngeal cancers. The book concludes with chapters that inform readers about the value of prebiotics, postbiotics and postbiotics in cancer therapy as adjuvants and immunotherapeutic agents.
Key features
- Gives a new dimension and insight in the role of probiotics in anticancer immunity towards various human cancers
- Provides several color figures and tables to clearly explain relevant information.
- Includes recent information with new insights and references
- Meets the needs of basic (pre-clinical) and advanced clinical researchers and postgraduate scholars
Table of Contents
Chapter 1 Prostate Cancer (Pca): a Brief Overview
- Gut Microbiota and Tumor Microenvironment
- Role of Probiotics in Prostate Cancer
- Probiotic-Based Anticancer Mechanisms Involved in the Treatment of Prostate Cancer
- Gut Microbiota in Anticancer Therapy for Prostate Cancer
- Conclusion
- Acknowledgement
- References
Chapter 2 Probiotics-Based Anticancer Immunity in Bladder Cancer
- Bladder Cancer: Epidemiology, Staging, Treatment, Risk Factors and Diagnosis
- Urinary Microbiota
- Urinary Microbiota and Bladder Cancer
- Bladder Cancer and Probiotics
- Bladder Cancer and Bacille Calmette-Guérin
- Bladder Cancer and Intravesical Probiotics: in Vitro and in Vivo Studies
- Bladder Cancer and Oral Probiotics
- Mechanisms of Probiotics in the Prevention/Treatment of Bladder Cancer
- Bladder Cancer and Probiotics as Gene Therapy
- Conclusion
- Acknowledgement
- References
Chapter 3 Probiotics-Based Anticancer Immunity in Pancreatic Cancer
- Introduction
- Effect of Probiotics on Reducing the Risk Factors and Outcomes Associated With Pancreatic Cancer (Pc)
- Effect of Probiotics on Pancreatic Cancer Initiation and Progression and Its Associated Mechanisms
- Anti-Proliferative and Anti-Metastatic Property
- Enhancement of Nk Cell Activity and Induction of Antitumor Immunity
- Increased Efficacy of Chemotherapy-Mediated Apoptosis and Maintenance of Gut Homeostasis
- Production of Compounds Having Anticarcinogenic Activity
- Increased Chemosensitivity of Pancreatic Cancer Cell
- Direct Tumor-Killing Effect/ Cell Cycle Arrest and Apoptosis
- Probiotic-Mediated Gut Microbiota Modulation and Its Possible Immunological Implication in Pancreatic Cancer (Pc)
- Future Perspectives
- Conclusion
- Acknowledgements
- References
Chapter 4 Probiotics-Based Anticancer Immunity in Oral and Oropharyngeal Cancer
- Introduction
- Probiotics in Cancer
- Immunity and Cancer
- Cancer and Innate Immune System Interactions
- Natural Killer Cells
- Macrophages
- Dendritic Cells (Dcs)
- Polymorphonuclear Leukocytes (Pmn) and Mast Cells
- Oral Cancer
- General Introduction, Risk Factors, Incidences, Mortality and Biomarkers
- Pathogenesis of Oral Squamous Cell Carcinoma (Oscc)
- Tumor-Node-Metastasis (Tnm) Staging System for Oral Carcinoma
- Primary Tumor (T)
- Regional Lymph Nodes (N)
- Distant Metastasis (M)
- Oral Microbiota Dysbiosis in Oral Cancer
- Factors That Influence the Choice of Initial Treatment of Oral Cavity Carcinomas
- Tumor Factors
- Patient Factors
- Physician Factors
- Surgical Approach
- Oropharyngeal Cancer (Opc)
- Symptoms of Oropharyngeal Cancer
- Diagnosis and Treatment of Oropharyngeal Cancer
- Role of Probiotics in Anticancer Immunity Against Oral and Oropharyngeal Cancers
- Current Challenges and Future Prospects
- Conclusion
- Acknowledgements
- References
Chapter 5 Probiotics-Based Anticancer Immunity in Thyroid Cancer
- Introduction
- Thyroid Cancer
- Types of Thyroid Cancer
- Papillary Thyroid Cancer
- Follicular Thyroid Cancer
- Anaplastic Thyroid Cancer
- Medullary Thyroid Cancer
- Signs of Thyroid Cancer
- Probiotics and Human Health
- Probiotics Improve the Immune Balance
- Role of Probiotics in Cancer
- Lactobacillus Sp.
- Role of the Immune System in Eradicating Cancer Cells
- Mechanisms of Probiotics in Prevention and Treatment of Thyroid Cancer
- Conclusion
- Acknowledgement
- References
Chapter 6 Probiotics-Based Anticancer Immunity in Lymphomas
- Introduction
- Lymphoma
- Gut Microbiota
- Gut Microbiota and Its Interaction With the Host
- Gut Microbiota and Chemotherapy
- Prevention of Lymphoma by Targeting the Microbiota
- The Role of Microflora and Its Components in Curing Cancer
- Gut Microbiota in the Modulation of Chemotherapy
- Gut Microbiota in the Modulation of Immunotherapy
- Gut Microbiota as Immune Checkpoint Inhibitors (Icis) in Lymphoma
- Probiotics
- Modification of the Gut Microflora Composition
- Metabolic Activity of Intestinal Microflora
- Production of Compounds With Anti-Carcinogenic Activity
- Inhibition of Cell Proliferation and Induction of Apoptosis in Cancer Cells
- Influence on Other Mutagenic and Carcinogenic Factors
- Binding and Degradation of Carcinogenic Compounds
- Immunomodulation
- Improvement of the Intestinal Barrier
- Conclusion
- Acknowledgements
- References
Chapter 7 Probiotics-Based Anticancer Immunity in Renal Cell Carcinoma
- Introduction
- Renal Cell Carcinoma and Its Pathology
- Probiotics and Their Role in Cellular Proliferation
- Alteration of the Gut Microbiome in Rcc
- Variations Related to the Metabolic Activity of the Gut Microbiome
- Breakdown of Compounds With Carcinogenic Potential in Git
- Producing Compounds That Mitigate Carcinogens
- Immunomodulation by Probiotics
- Effect of Probiotics on Cancer Cells
- Antioxidative Functions
- The Gut Microbiata and Immune Checkpoint Inhibition
- Role of Gut Microbiome in Renal Cell Carcinoma Management
- Conclusion
- Acknowledgement
- References
Chapter 8 Probiotics as Adjuvants in Anticancer Immunity
- Introduction
- Possible Mechanisms and Interrelation Between Human Microbiome, Cancer, and Probiotics Administration
- Dual Crosstalk of Human Microbiota in Cancer
- Commensal Microbiome, Anticancer Immunity, and Probiotics Intervention
- Human Immune System and Cancer Immunity
- Commensal Microbiota and Its Specific Roles
- Treatment Strategy
- Immune Checkpoint Inhibitors
- Live Probiotics
- Dead Probiotics
- Probiotic Metabolites as Adjuvants
- Short-Chain Fatty Acids (Scfas)
- Bile Acids (Ba)
- Purine and Its Metabolites
- Peptides
- Incongruities: Other Metabolites in Cancer Progression
- Probiotic Action on Other Carcinogenic Factors
- Probiotics as Adjuvants in the Management of Chemotherapyrelated Complications
- Prevention of Infections and Febrile Neutropenia in Cancer
- Prevention and Treatment of Chemotherapy and Radiation-Induced Diarrhoea by Using Probiotics
- Probiotics and High-Efficiency Biotherapeutics
- Safety of Probiotics as Adjuvants
- Future Perspective
- Conclusion
- Acknowledgement
- References
Chapter 9 Prebiotics and Postbiotics for Anticancer Immunity
- Introduction
- Immunotherapy Approaches for Cancer Treatment
- Prebiotics and Their Effects on Anticancer Immunity
- Postbiotics and Their Effects on Anticancer Immunity
- Future Prospects
- Conclusion
- Acknowledgement
- References
Author
- Mitesh Kumar Dwivedi
- Sanjay Tiwari
- Alwarappan Sankaranarayanan
