The Lung: Development, Aging and the Environment, Third Edition provides an understanding of the multifaceted nature of lung development, aging and the environment influences of these processes. As an essential resource to respiratory, pulmonary and thoracic scientists and physicians, this book provides an interface between the "normal" and "disease" cluster of chapters, allowing for a natural complement. The interface between different lung diseases affecting the pediatric lung also adds a useful source for comparing how different lung diseases share key pathophysiological features. This same complementarity comes across in the logical line up of chapters dealing with the "normal" pediatric lung.
New research, including cell-based strategies for infant lung function, epigenetics and prenatal environmental exposure (including wildfires) on lung development and function are some of the important additions to this edition of this reference work.
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Table of Contents
Part I: Critical Events in Normal Development and Aging 1. Lung Progenitor Cell Specification and Morphogenesis 2. Alveolar Development 3. Development of the Innervation of the Lower Airways: Structure and Function 4. Pulmonary Vascular Development 5. Developmental Physiology of the Pulmonary Circulation 6. Physical, Endocrine, and Growth Factors in Lung Development 7. The Development and FUnction of the Pulmonary Surfactant System in Health, Prematurity, and Genetic Disease 8. Ontogeny of the Pulmonary Immune System 9. Macrophages and the Lung 10. Adaptation to Mechanical Signals in the Lung: Recruitment of Reserves, Remodeling, and Regrowth 11. Pulmonary Transition at Birth 12. Normal Aging of the Lung Part II: Environmental and Disease Influences on Lung Development and Aging 13. Epigenetics and the Developmental Origins of Lung Disease 14. Pulmonary Consequences of Preterm Birth 15. Preterm Birth and the Developing Lung: Programming Effects on Lung Structure and Function 16. The Effects of Neonatal Hyperoxia on Lung Development 17. Restricted Growth During Early Development: Effects on Lung Structure and Lung Function 18. Cell-Based Strategies for the Treatment of Injury to the Developing Lung 19. Effects of Environmental Tobacco Smoke during Early Life Stages 20. Nicotine Exposure during Early Development: Effects on the Lung 21. Implications of Early Life Exposures to Electronic Nicotine Delivery System (ENDS) Aerosols 22. In Utero Exposure to Allergens and Development of the Allergic Phenotype in the Neonate 23. Effect of Environment on the Developing and Adult Pulmonary Surfactant System and in the Aging Lung 24. Environmental Determinants of Lung Aging 25. The Role of Epigenetics in Lung Diseases and Environmental Exposures 26. The Dynamic Microbiotal Changes in the Human: Impact on the Developing Lung 27. Viral Respiratory Pathogens and Lung Injury in Pregnancy, with Focus on Epidemiology and Pathophysiology of ARDS amidst the COVID-19 Pandemic 28. The Lung Exposome: Accelerating Precision Respiratory Health
Authors
Kent Pinkerton Professor of Pediatrics, School of Medicine, University of California, Davis, USA. Kent Pinkerton, MD, is professor of pediatrics, School of Medicine, and director of the Center for Health and the Environment at the University of California, Davis.His research focuses on the health effects of inhaled environmental air pollutants to alter respiratory, cardiovascular, and neurological structure and function. Special areas of interest include the interaction of gases and airborne particles to produce cellular and structural changes within site-specific regions and cells of the respiratory tract in both acute and chronic timeframes of exposure. Recent studies have focused on environmental and biological impacts of synthesized nanomaterials as well as the effects of environmental tobacco smoke and combustion particles on lung growth and development.
He is associate director for the San Joaquin Aerosol Health Effects Research Center (SAHERC) to study airborne particles of the San Joaquin Valley. He is also the associate director for the Western Center for Agricultural Health and Safety (WCAHS) to study the health effects of airborne particles in an agricultural setting. Richard Harding Emeritus Professor, Department of Anatomy and Developmental Biology, Monash University, Clayton, Australia. Richard Harding is a NHMRC Senior Principal Research Fellow and an Emeritus Professor with the Department of Anatomy and Developmental Biology at Monash University, Australia. His research focuses on Respiratory Development and Programming. He is now semi-retired. Elizabeth Georgian
