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Gene Synthesis Market Report and Forecast 2024-2032

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    Report

  • 140 Pages
  • May 2024
  • Region: Global
  • Expert Market Research
  • ID: 5855166
The global gene synthesis market size was valued at USD 1.9 billion in 2023. It is expected to grow at a CAGR of 18.4% during the forecast period of 2024-2032, driven by technological advancements in synthesis efficiency across the globe. The market is experiencing robust growth and is expected to reach USD 8.5 billion by 2032.

Global Gene Synthesis Market Analysis

The global gene synthesis market is experiencing significant growth, driven by rapid advancements in synthetic biology and an increasing demand for synthetic genes across various sectors, including biotechnology, pharmaceuticals, and academic research. Gene synthesis, the process of artificially constructing genetic material in vitro, has become an invaluable tool for researchers and companies focusing on drug discovery, vaccine development, and genetic engineering.

Market Drivers

Several key drivers are propelling the growth of the gene synthesis market. First, there's a growing demand for personalized medicine, which relies on genetic information to tailor treatments to individual patients. This has led to an increased need for synthetic genes in drug development and diagnostic processes. Additionally, advancements in DNA synthesis technologies have significantly reduced the cost and time required to synthesize genes, making gene synthesis more accessible and affordable for a wider range of applications.

The rise of the synthetic biology field, which combines biology with engineering principles to design and construct new biological parts, devices, and systems, is another major driver. Synthetic genes are crucial components in synthetic biology, used to create novel organisms or modify existing ones for various purposes, including biofuel production, bioremediation, and agriculture.

Market Challenges

Despite the market's growth, there are challenges that need addressing. Intellectual property and ethical issues surrounding the creation and use of synthetic genes pose significant concerns. The potential misuse of gene synthesis technology for harmful purposes, such as bioterrorism, also raises biosecurity issues, necessitating strict regulations and oversight.

The technical limitations of current gene synthesis technologies, including errors in gene assembly and difficulties in synthesizing long DNA sequences, represent additional hurdles. Overcoming these challenges requires ongoing research and development efforts to improve accuracy and efficiency.

Global Gene Synthesis Market Trends

The global gene synthesis market is characterized by several emerging trends that underscore its dynamic nature and the significant impact of technological advancements. These trends not only reflect the current state of the market but also hint at its future direction, emphasizing the growing role of gene synthesis in various scientific and commercial applications.

1. Technological Advancements in Synthesis Efficiency

One of the most notable trends is the continuous improvement in gene synthesis technologies. Innovations in synthesis methods, such as automated DNA synthesizers and microfluidic devices, have increased efficiency, reduced error rates, and lowered the cost of gene synthesis. These advancements have made gene synthesis more accessible to a broader range of researchers and companies, facilitating more complex genetic engineering projects.

2. Rise of Custom and Large-Scale Gene Synthesis

There's an increasing demand for custom gene synthesis services that cater to specific research needs, including the synthesis of long or complex DNA sequences. Additionally, large-scale gene synthesis projects, which are crucial for synthetic biology applications like genome engineering and the development of synthetic organisms, are becoming more common. This trend is driven by the expanding capabilities of gene synthesis platforms to handle large volumes of custom orders efficiently.

3. Expansion into New Applications

Gene synthesis is finding new applications beyond traditional fields. In healthcare, it's pivotal in developing personalized medicine, vaccine design, and therapeutic proteins. In agriculture, gene synthesis is used to engineer crops for better yield, disease resistance, and nutritional value. Environmental applications, such as bioremediation using genetically engineered microbes, are also on the rise. This diversification is expanding the market into new sectors.

4. Integration with CRISPR and Other Genome Editing Technologies

The integration of gene synthesis with CRISPR-Cas9 and other genome editing technologies is a significant trend. Gene synthesis provides custom DNA templates for CRISPR applications, enabling precise genome modifications. This synergy is accelerating research in genetics, improving the development of gene therapies, and enhancing the capabilities of synthetic biology.

5. Ethical, Regulatory, and Biosecurity Considerations

As gene synthesis technology becomes more powerful, ethical, regulatory, and biosecurity issues become increasingly important. There's a growing focus on developing guidelines and regulations to ensure the responsible use of gene synthesis, particularly concerning dual-use research that could be misapplied. The industry is actively engaging with policymakers, researchers, and the public to address these concerns.

6. Globalization and Collaboration

The gene synthesis market is becoming more globalized, with significant growth in regions outside of traditional hubs in North America and Europe, particularly in Asia Pacific. International collaborations between companies, academic institutions, and governments are fostering innovation and driving the market's expansion. These partnerships are crucial for sharing knowledge, technology, and resources, contributing to the global advancement of gene synthesis applications.

These trends indicate a market that is rapidly evolving, fueled by technological innovations and expanding into new applications and regions. As the gene synthesis market continues to grow, these trends will shape its trajectory, offering new opportunities and challenges for stakeholders in the field.

Global Gene Synthesis Market Segmentation

Market Breakup by Component

  • Synthesizer
  • Consumables
  • Software and Services
The global gene synthesis market is segmented by components into synthesizers, consumables, and software and services, each playing a pivotal role in driving market growth. Synthesizers, essential for the physical assembly of DNA sequences, are witnessing advancements that enhance efficiency and throughput, catering to the increasing demand for synthetic genes. Consumables, including reagents and kits, are critical for the synthesis process, with ongoing developments aimed at reducing costs and improving reliability. Software and services, offering design, optimization, and analysis tools, are becoming increasingly sophisticated, enabling more complex gene synthesis projects.

Together, these segments are poised to propel the gene synthesis market forward, supported by technological advancements, growing applications in research and biotechnology, and the expanding synthetic biology field. This comprehensive approach to gene synthesis, incorporating hardware, consumables, and digital solutions, is expected to drive significant market expansion in the forecast period.

Market Breakup by Gene Type

  • Standard Gene
  • Express Gene
  • Complex Gene
  • Others
The gene synthesis market is segmented by gene type into standard genes, express genes, complex genes, and others, each catering to specific needs and applications. Standard genes, often used for basic research and genetic studies, form the backbone of the market due to their broad applicability and demand across various scientific fields. Express genes, designed for rapid synthesis and delivery, address the need for speed in projects with tight timelines, reflecting the market's responsiveness to research urgency. Complex genes, which include sequences with high GC content, repeats, or other challenging features, represent a growing segment due to advancements in synthesis technologies that can tackle these complexities. The "others" category encompasses specialized gene products tailored for niche applications, such as synthetic biology, therapeutic development, and agricultural biotechnology. This segmentation highlights the market's diverse offerings, with future growth driven by the expanding capabilities in gene synthesis technology, increasing demand for custom solutions, and the broadening scope of applications requiring synthesized genes.

Market Breakup by Gene Synthesis Type

  • Gene Library Synthesis
  • Custom Gene Synthesis
  • Others
The gene synthesis market is categorized by gene synthesis type into gene library synthesis, custom gene synthesis, and others, each addressing distinct demands within the field. Gene library synthesis, which involves the creation of vast collections of genetic sequences, is pivotal for high-throughput screening, functional genomics, and synthetic biology applications, indicating substantial growth due to the expanding need for comprehensive genomic studies and bioengineering projects. Custom gene synthesis, offering tailored genetic sequences to specific researcher or industry requirements, is another major segment, driven by its critical role in personalized medicine, vaccine development, and agricultural modifications.

The "others" category captures emerging and specialized gene synthesis services that cater to niche applications, further broadening the market's scope. The diversification in gene synthesis types reflects the evolving complexity and specificity of research and commercial projects in biotechnology, underpinning the market's growth trajectory as technologies advance and applications widen.

Market Breakup by Method

  • Solid Phase
  • Synthesis Chip-Based DNA Synthesis
  • PCR-Based Enzyme Synthesi
  • Others
The gene synthesis market is diversified by method into solid-phase synthesis, chip-based DNA synthesis, PCR-based enzyme synthesis, and others, reflecting the evolving landscape of gene construction technologies. Solid-phase synthesis, a traditional and widely used method, remains foundational due to its reliability and well-understood mechanics. Chip-based DNA synthesis represents a cutting-edge approach, offering high-throughput capabilities and cost-efficiency by synthesizing thousands of oligonucleotides simultaneously on a single chip, catering to the demand for large-scale projects such as gene libraries. PCR-based enzyme synthesis, known for its versatility and efficiency in amplifying specific DNA sequences, is particularly valuable for custom gene synthesis and modifications.

Market Breakup by Application

  • Synthetic Biology
  • Genetic Engineering
  • Vaccine Design
  • Therapeutics Antibodies
  • Others
The gene synthesis market, segmented by application into synthetic biology, genetic engineering, vaccine design, therapeutic antibodies, and others, showcases a varied landscape of growth drivers and future potential. Synthetic biology, at the forefront, leverages gene synthesis for constructing novel biological parts, systems, and organisms, driving demand for both custom and library gene synthesis. Genetic engineering, involving the direct manipulation of an organism's genes, relies heavily on gene synthesis for creating genetically modified crops, animals, and microbes with enhanced traits. Vaccine design has emerged as a critical application, especially highlighted by the rapid development of mRNA vaccines against COVID-19, where gene synthesis plays a pivotal role in designing antigens based on viral genetic sequences.

The development of therapeutic antibodies, another significant application, utilizes gene synthesis for creating monoclonal antibodies for a wide range of diseases, from cancer to autoimmune disorders. The "others" category encompasses a broad range of emerging applications, including drug discovery, metabolic engineering, and environmental biotechnology, each contributing to the market's expansion. This segmentation underscores the integral role of gene synthesis across diverse biotechnological and pharmaceutical research areas, poised for significant growth as advancements in synthesis technologies continue to broaden the scope and efficiency of applications.

Market Breakup by End User

  • Academic and Research Institutes
  • Diagnostics Laboratories
  • Biotech & Pharmaceutical Companies
  • Others
The gene synthesis market, segmented by end-user, includes academic and research institutes, diagnostics laboratories, biotech and pharmaceutical companies, and others, showcasing a diverse range of applications and growth prospects. Academic and research institutes form a significant segment, driven by their extensive use of gene synthesis for basic research, genetic studies, and educational purposes. Diagnostics laboratories are increasingly adopting gene synthesis for developing advanced diagnostic tests, including those for infectious diseases and genetic disorders. Biotech and pharmaceutical companies represent a rapidly growing segment, utilizing gene synthesis for drug discovery, vaccine development, and therapeutics antibodies production.

Market Breakup by Region

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East and Africa
The global gene synthesis market is witnessing substantial growth across different regions, driven by varying factors. In North America, the market's expansion is propelled by cutting-edge research in biotechnology and pharmaceuticals, coupled with strong governmental support and funding for genomics projects. Europe follows, with its growth underpinned by a robust framework for biotech innovation, significant investment in R&D, and a growing focus on personalized medicine. The Asia Pacific region is the fastest-growing market, thanks to rising investments in healthcare infrastructure, increasing prevalence of genetic disorders, and booming biotech industries in countries like China and India. Meanwhile, Latin America and the Middle East and Africa are emerging markets, experiencing gradual growth due to improving healthcare systems, increasing awareness about genetic diseases, and growing government initiatives in research and development. Collectively, these regional dynamics showcase a global gene synthesis market poised for continued expansion, reflecting the increasing importance of genetic research and personalized medicine worldwide.

Global Gene Synthesis Market Competitive Landscape

The global gene synthesis market is marked by a competitive landscape featuring a mix of established companies and emerging players, each contributing to the field's growth with their specialized offerings. Creative Biogene, Bioneer Pacific, B. Braun Melsungen AG, MACROGEN CO., LTD., General Biosystems, Inc., ATDBio Ltd (Subsidiary of Biotage), OriGene Technologies, Inc., Integrated DNA Technologies, Inc., Thermo Fisher Scientific, Inc., ProMab Biotechnologies, Inc., Biomatik, ProteoGenix, Inc., Twist Bioscience, Boster Biological Technology, Brooks Automation, Inc. (GENEWIZ) and GenScript are known for their innovative gene synthesis solutions, catering to a wide range of research and industrial applications.

Key Questions Answered in This Report

  • What is the current and future performance of the global gene synthesis market?
  • What are the main factors driving the increasing demand and accessibility of gene synthesis in various fields?
  • What challenges and concerns are impacting the growth of the gene synthesis market, and how are they being addressed?
  • How are innovations in gene synthesis technologies enhancing efficiency, reducing costs, and facilitating complex genetic engineering projects?
  • How are the segments of synthesizers, consumables, and software and services collectively driving growth in the global gene synthesis market?
  • How is the diversity in gene types, including standard, express, and complex genes, addressing varied applications and driving growth in the gene synthesis market?
  • How are different types of gene synthesis, including gene library and custom synthesis, catering to specific market demands and driving the sector's growth?
  • How are diverse end-user segments, including academic, diagnostics, and biotech sectors, driving the expansion and application diversity of the gene synthesis market?
  • How is the competitive landscape of the global gene synthesis market shaped by the mix of established companies and emerging innovators?
  • What are the main players/companies in the market?

Key Benefits for Stakeholders

  • The industry report offers a comprehensive quantitative analysis of various market segments, historical and current market trends, market forecasts, and dynamics of the global gene synthesis market from 2017-2032.
  • The research report provides the latest information on the market drivers, challenges, and opportunities in the global gene synthesis market.
  • The study maps the leading, as well as the fastest-growing, regional markets. It further enables stakeholders to identify the key country-level markets within each region.
  • Porter's five forces analysis assists stakeholders in assessing the impact of new entrants, competitive rivalry, supplier power, buyer power, and the threat of substitution. It helps stakeholders to analyze the level of competition within the global gene synthesis industry and its attractiveness.
  • The competitive landscape allows stakeholders to understand their competitive environment and provides insight into the current positions of key players in the market.


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Table of Contents

1 Preface
1.1 Objectives of the Study
1.2 Key Assumptions
1.3 Report Coverage - Key Segmentation and Scope
1.4 Research Methodology
2 Executive Summary
3 Global Gene Synthesis Market Overview
3.1 Global Gene Synthesis Market Historical Value (2017-2023)
3.2 Global Gene Synthesis Market Forecast Value (2024-2032)
4 Global Gene Synthesis Market Landscape
4.1 Gene Synthesis: Developers Landscape
4.1.1 Analysis by Year of Establishment
4.1.2 Analysis by Company Size
4.1.3 Analysis by Region
4.2 Gene Synthesis: Product Landscape
4.2.1 Analysis by Type
4.2.2 Analysis by Technology
4.2.3 Analysis by Applications
5 Global Gene Synthesis Market Dynamics
5.1 Market Drivers and Constraints
5.2 SWOT Analysis
5.3 Porter’s Five Forces Model
5.4 Key Demand Indicators
5.5 Key Price Indicators
5.6 Industry Events, Initiatives, and Trends
5.7 Value Chain Analysis
6 Global Gene Synthesis Market Segmentation
6.1 Global Gene Synthesis Market by Components
6.1.1 Market Overview
6.1.2 Synthesizer
6.1.3 Consumables
6.1.4 Software and Services
6.2 Global Gene Synthesis Market by Gene Therapy
6.2.1 Market Overview
6.2.2 Standard Gene
6.2.3 Express Gene
6.2.4 Complex Gene
6.2.5 Others
6.3 Global Gene Synthesis Market by Application
6.3.1 Market Overview
6.3.2 Synthetic Biology
6.3.3 Genetic Engineering
6.3.4 Vaccine Design
6.3.5 Therapeutics Antibodies
6.3.6 Others
6.4 Global Gene Synthesis Market by Gene Synthesis Type
6.4.1 Market Overview
6.4.2 Gene Library Synthesis
6.4.3 Solid Phase Synthesis
6.4.4 Chip-Based DNA Synthesis
6.4.5 PCR-Based Enzyme Synthesis
6.5 Global Gene Synthesis Market by Region
6.5.1 Market Overview
6.5.2 North America
6.5.3 Europe
6.5.4 Asia Pacific
6.5.5 Latin America
6.5.6 Middle East and Africa
7 North America Gene Synthesis Market
7.1 Market Share by Country
7.2 United States of America
7.3 Canada
8 Europe Gene Synthesis Market
8.1 Market Share by Country
8.2 United Kingdom
8.3 Germany
8.4 France
8.5 Italy
8.6 Others
9 Asia Pacific Gene Synthesis Market
9.1 Market Share by Country
9.2 China
9.3 Japan
9.4 India
9.5 ASEAN
9.6 Australia
9.7 Others
10 Latin America Gene Synthesis Market
10.1 Market Share by Country
10.2 Brazil
10.3 Argentina
10.4 Mexico
10.5 Others
11 Middle East and Africa Gene Synthesis Market
11.1 Market Share by Country
11.2 Saudi Arabia
11.3 United Arab Emirates
11.4 Nigeria
11.5 South Africa
11.6 Others
12 Regulatory Framework
12.1 Regulatory Overview
12.1.1 US FDA
12.1.2 EU EMA
12.1.3 INDIA CDSCO
12.1.4 JAPAN PMDA
12.1.5 Others
13 Patent Analysis
13.1 Analysis by Type of Patent
13.2 Analysis by Publication year
13.3 Analysis by Issuing Authority
13.4 Analysis by Patent Age
13.5 Analysis by CPC Analysis
13.6 Analysis by Patent Valuation
13.7 Analysis by Key Players
14 Grants Analysis
14.1 Analysis by year
14.2 Analysis by Amount Awarded
14.3 Analysis by Issuing Authority
14.4 Analysis by Grant Application
14.5 Analysis by Funding Institute
14.6 Analysis by NIH Departments
14.7 Analysis by Recipient Organization
15 Clinical Trials Analysis
15.1 Analysis by Trial Registration Year
15.2 Analysis by Trial Status
15.3 Analysis by Trial Phase
15.4 Analysis by Therapeutic Area
15.5 Analysis by Geography
16 Funding and Investment Analysis
16.1 Analysis by Funding Instances
16.2 Analysis by Type of Funding
16.3 Analysis by Funding Amount
16.4 Analysis by Leading Players
16.5 Analysis by Leading Investors
16.6 Analysis by Geography
17 Partnership and Collaborations Analysis
17.1 Analysis by Partnership Instances
17.2 Analysis by Type of Partnership
17.3 Analysis by Leading Players
17.4 Analysis by Geography
18 Supplier Landscape
18.1 ATDBio Ltd
18.1.1 Financial Analysis
18.1.2 Product Portfolio
18.1.3 Demographic Reach and Achievements
18.1.4 Mergers and Acquisitions
18.1.5 Certifications
18.2 General Biosystems
18.2.1 Financial Analysis
18.2.2 Product Portfolio
18.2.3 Demographic Reach and Achievements
18.2.4 Mergers and Acquisitions
18.2.5 Certifications
18.3 Macrogen CO.
18.3.1 Financial Analysis
18.3.2 Product Portfolio
18.3.3 Demographic Reach and Achievements
18.3.4 Mergers and Acquisitions
18.3.5 Certifications
18.4 Boster Biological Technology
18.4.1 Financial Analysis
18.4.2 Product Portfolio
18.4.3 Demographic Reach and Achievements
18.4.4 Mergers and Acquisitions
18.4.5 Certifications
18.5 Creative Biogene
18.5.1 Financial Analysis
18.5.2 Product Portfolio
18.5.3 Demographic Reach and Achievements
18.5.4 Mergers and Acquisitions
18.5.5 Certifications
18.6 Bioneer Pacific,
18.6.1 Financial Analysis
18.6.2 Product Portfolio
18.6.3 Demographic Reach and Achievements
18.6.4 Mergers and Acquisitions
18.6.5 Certifications
18.7 Exonbio
18.7.1 Financial Analysis
18.7.2 Product Portfolio
18.7.3 Demographic Reach and Achievements
18.7.4 Mergers and Acquisitions
18.7.5 Certifications
18.8 trenzyme GmbH
18.8.1 Financial Analysis
18.8.2 Product Portfolio
18.8.3 Demographic Reach and Achievements
18.8.4 Mergers and Acquisitions
18.8.5 Certifications
18.9 Twist Bioscience
18.9.1 Financial Analysis
18.9.2 Product Portfolio
18.9.3 Demographic Reach and Achievements
18.9.4 Mergers and Acquisitions
18.9.5 Certifications
18.10 BioCat GmbH
18.10.1 Financial Analysis
18.10.2 Product Portfolio
18.10.3 Demographic Reach and Achievements
18.10.4 Mergers and Acquisitions
18.10.5 Certifications
18.11 OriGene Technologies, Inc.
18.11.1 Financial Analysis
18.11.2 Product Portfolio
18.11.3 Demographic Reach and Achievements
18.11.4 Mergers and Acquisitions
18.11.5 Certifications
18.12 Integrated DNA Technologies
18.12.1 Financial Analysis
18.12.2 Product Portfolio
18.12.3 Demographic Reach and Achievements
18.12.4 Mergers and Acquisitions
18.12.5 Certifications
18.13 Eurofins Scientific
18.13.1 Financial Analysis
18.13.2 Product Portfolio
18.13.3 Demographic Reach and Achievements
18.13.4 Mergers and Acquisitions
18.13.5 Certifications
18.14 NZYTech
18.14.1 Financial Analysis
18.14.2 Product Portfolio
18.14.3 Demographic Reach and Achievements
18.14.4 Mergers and Acquisitions
18.14.5 Certifications
18.15 Genes and Enzymes
18.15.1 Financial Analysis
18.15.2 Product Portfolio
18.15.3 Demographic Reach and Achievements
18.15.4 Mergers and Acquisitions
18.15.5 Certifications
19 Key Opinion Leaders (KOL) Insights (Additional Insight)
20 Company Competitiveness Analysis (Additional Insight)
20.1 Very Small Companies
20.2 Small Companies
20.3 Mid-Sized Companies
20.4 Large Companies
20.5 Very Large Companies
21 Payment Methods (Additional Insight)
21.1 Government Funded
21.2 Private Insurance
21.3 Out-of-Pocket
*Additional insights provided are customisable as per client requirements.

Companies Mentioned

  • ATDBio Ltd
  • General Biosystems
  • Macrogen CO.
  • Boster Biological Technology
  • Creative Biogene
  • Bioneer Pacific,
  • Exonbio
  • trenzyme GmbH
  • Twist Bioscience
  • BioCat GmbH
  • OriGene Technologies, Inc.
  • Integrated DNA Technologies
  • Eurofins Scientific
  • NZYTech
  • Genes and Enzymes

Methodology

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Table Information