Understand the use of heat to destroy tumors with this comprehensive guide
Heat is an indispensable resource in the destruction of cancerous tumors to potentially treat cancers. There are also real challenges, however, involved in the total destruction of tumors without destroying healthy tissue surrounding the tumor in the process. A detailed understanding of the propagation of thermal energy, induced heating, and tissue responses to heat is required to safely and successfully apply heat-based technologies in clinical oncology.
The Application of Heat in Oncology supplies this understanding, with a thorough, comprehensive overview of the principle and practice involved. Offering both a detailed introduction to the physics and thermodynamics of induced heat and an analysis of its clinical applications, this is an essential resource for clinicians, technicians, and others in oncological practice.
The Application of Heat in Oncology readers will also find: - Guidelines for applying heat both safely and effectively - Detailed discussion of topics including energy delivery (e.g., via RF, MW, ultrasound, laser, cryoagents, hyperthermia, nanoparticles, etc.), temperature assessment, damage assessment, image guidance, and more - Summary of current practice along with suggestions for future areas of technological improvement
The Application of Heat in Oncology is ideal for all clinicians working in the field of cancer treatment, including medical students, residents, researchers, engineers, radiologists, surgeons, and more.
Table of Contents
List of Contributors xxi
Preface xxv
Part A Principles 1
A.1 Delivering Energy 3
1 Propagation of Radiofrequency and Microwaves in Tissue 5
Punit Prakash and Anna Bottiglieri
2 Propagation of Focused Ultrasound in Tissue 19
Gregory T. Clement
3 Propagation of Light in Tissue 31
Do-Hyun Kim
4 Mechanisms of Tissue Injury in Cryosurgery 45
John G. Baust, Kimberly L. Santucci, Kristi K. Snyder, Anthony Robilotto, and John M. Baust
5 Delivering Energy using Localized Hyperthermia Systems 73
Hana Dobsicek Trefna, Johannes Crezee, and Petra Kok
6 Role of Nanoparticles Mediated Heating in Oncology 95
Gennaro Bellizzi
A.2 Assessing Temperatures 107
7 Temperature Monitoring During Thermal Treatment by Thermocouples and Thermistors: Current Status and Perspectives 109
Francesca De Tommasi, Carlo Massaroni, Daniela Lo Presti, Rosario Francesco Grasso, Massimiliano Carassiti, Yuman Fong, and Emiliano Schena
8 Fluorescent-Decay Temperature Probes for Biomedical Applications: Theory, Techniques, and Practical Advice 121
Daryl James and Harry Vine
9 Calibration and Use of Infrared Thermal Cameras in Biological Applications 135
Michael L. Denton and Gary D. Noojin
10 Magnetic Resonance Thermometry in Oncology: Applications in Moving Organs 149
Henrik Odéen and Dennis L. Parker
11 Measuring Tissue Temperature with Ultrasound 175
Elyas Shaswary and Jahangir (Jahan) Tavakkoli
12 Current Status and Future Potential of Thermometry Based on Computed Tomography Imaging 195
Francesca De Tommasi, Carlo Massaroni, Daniela Lo Presti, Rosario Francesco Grasso, Massimiliano Carassiti, Yuman Fong, and Emiliano Schena
13 A Generic Thermal Model to Predict Temperatures in Perfused Tissues 205
Devashish Shrivastava
A.3 Assessing Damage 217
14 Measuring Thermal Damage with Gross and Microscopic Pathology 219
Sharon Thomsen
15 Assessing Thermal Damage with Magnetic Resonance Imaging 251
Sara L. Johnson and Allison H. Payne
16 Ultrasound Imaging Techniques for the Evaluation of Thermal Damage 273
Jenna Osborn
17 Mathematical Models of Thermal Damage and Cell Death 289
John Pearce
18 A Novel Method to Indicate Onset of Photothermal Damage 307
Michael L. Denton, Gary D. Noojin, and Elharith M. Ahmed
19 Thermodynamic Challenges of Using Magnetic Resonance Thermometry in Measuring in vivo Temperatures and Estimating Thermal Damage in Thermal Ablation 329
Devashish Shrivastava
Part B Clinical Applications 341
20 Biological and Physical Aspects of Heat Therapy 343
Abhijit Mandal, Ritusha Mishra, and Himanshu Mishra
21 Guiding Thermal Therapy with MR 359
Richard Tyc and Mark G. Torchia
22 Role of Radiofrequency Ablation and Laser-Induced Thermal Therapy in the Management of Functional Neurosurgery and Brain Lesions 377
Peter Konrad, Johnie Hodge, and Manish Ranjan
23 Radiofrequency and Microwave Thermal Ablation in Cancer Therapy and the Role of Hydrodissection 391
Arvind K. Chaturvedi
24 Role of High-Intensity Focused Ultrasound for Functional Neurosurgery and for the Management of Brain Lesions 403
Georgios A. Maragkos, Georgios Mantziaris, Shayan Moosa, and W. Jeffrey Elias
25 Role of HIFU in Cancer Management 425
Sofia Gereta, Judith Stangl-Kremser, Tenny R. Zhang, and Jim C. Hu
26 Percutaneous Cryoablation: Mechanism of Action, Clinical Applications, and Outcomes 459
Ahmed Farhan, Christopher R. Bailey, and Christos Georgiades
27 Clinical Applications of Hyperthermia 483
Himanshu Mishra, Ritusha Mishra, and Abhijit Mandal
28 Thermal Damage due to a Monopole Microwave Antenna 499
Marta Cavagnaro and Devashish Shrivastava
29 Thermal Damage with High-Intensity Focused Ultrasound 511
Devashish Shrivastava
30 Thermal Damage Due to Laser 519
Rahul Goyal and Devashish Shrivastava
31 Thermal Damage Due to Hot and Cold Surfaces 525
Devashish Shrivastava
32 MRI-Induced RF Heating Considerations for Devices and Accessories that are Partially in and Partially Out of the Human Body 533
Ran Guo, Md Zahidul Islam, Wolfgang Kainz, and Ji Chen
References 542
Index 545
