The proteinase K market size has grown strongly in recent years. It will grow from $4.89 billion in 2024 to $5.36 billion in 2025 at a compound annual growth rate (CAGR) of 9.7%. The growth in the historic period can be attributed to expanding biotechnology and life sciences research, diagnostic testing advancements, pharmaceutical development needs, bioprocessing and protein purification, quality control in food and beverages.
The proteinase K market size is expected to see rapid growth in the next few years. It will grow to $8.19 billion in 2029 at a compound annual growth rate (CAGR) of 11.2%. The growth in the forecast period can be attributed to continued growth in molecular diagnostics, advancements in precision medicine, biopharmaceutical manufacturing expansion, research in proteomics and genomics, and increased application in forensic sciences. Major trends in the forecast period include pharmaceutical industry growth, technological advancements, market competition and pricing, sustainable and animal-free variants, and global pandemic impact.
The anticipated growth of the proteinase K market is expected to be driven by the increasing prevalence of chronic diseases. Chronic diseases, lasting more than a year and requiring continuous medical treatment, are a significant target for proteinase K usage. The enzyme plays a crucial role in both preventative and therapeutic applications, facilitating the extraction and isolation of DNA and RNA from viruses associated with various chronic diseases. For instance, data from the National Library of Medicine in January 2023 projected a rise in the number of individuals aged 50 and older with at least one chronic condition in the US, reaching 142.66 million by 2050. This underscores the growing significance of proteinase K in addressing the needs of a population grappling with chronic diseases.
The rising incidence of infectious diseases, particularly tuberculosis, is projected to drive growth in the proteinase K market in the future. Tuberculosis (TB) is a bacterial infection caused by Mycobacterium tuberculosis, which primarily affects the lungs but can also impact other areas of the body. Proteinase K is used in TB research for the extraction and isolation of DNA and RNA from the Mycobacterium tuberculosis bacterium. For example, in February 2024, the UK government department GOV.UK reported a 10.7% increase in tuberculosis cases in England in 2023, rising from 4,380 in 2022 to 4,850. Thus, the growing incidence of infectious diseases like tuberculosis is expected to boost the proteinase K market.
The proteinase K market is witnessing a notable trend towards product innovation, with major companies actively launching novel products to strengthen their positions. One such example is Biocatalysts Ltd., a UK-based biotechnology company, which introduced Proteocut K. This high-quality and cost-effective alternative to liquid proteinase K is a subtilisin-type serine protease with broad substrate specificity, suitable for a variety of life science applications. Its efficient hydrolysis of various proteins is attributed to its broad pH profile (6 - 10.0) and temperature range (40 -70°C). This innovative offering enhances the choices available in the proteinase K market, providing users with a versatile enzyme solution.
Companies are focused on continuous product development to stay competitive. ArcticZymes Technologies ASA, a Norway-based biotechnology company, exemplifies this by upscaling production and launching a glycerol-free version of ArcticZymes Proteinase. Known for its high activity and stability, this enzyme is valuable in molecular biology protocols, diagnostics, and bioprocessing. The glycerol-free variant offers enhanced stability at -20°C for up to one year, making it suitable for lyophilization and automated processes.
In January 2023, Lighthouse Pharma, a US-based biopharmaceutical company, acquired the small molecule proteinase inhibitor portfolio from Quince Therapeutics Inc. This acquisition positions Lighthouse Pharma to advance the development of gingipain inhibitors for dementia and other disorders, offering innovative treatment options. Quince Therapeutics Inc., a US-based biotechnology company specializing in proteinase inhibitors, contributes valuable assets to Lighthouse Pharma's research and development efforts.
Major companies operating in the proteinase K market include Merck KGaA, QIAGEN NV, Thermo Fisher Scientific Inc., F Hoffmann-La Roche Ltd., Worthington Biochemical Corporation, Sigma-Aldrich Co. LLC, Behemoth Inteligencia para os Negocios LTDA, Codexis Inc., Beijing SBS Genetech Co. Ltd, Hoffmann-La Roche Ltd, Amicogen Inc, Amano Enzyme Inc., Sisco Research Laboratories Pvt. Ltd., Promega Corporation, Bioline Diagnostics LLP, Biocompare, BioVision Inc., Creative Enzymes, G-Biosciences, Advanced Enzymes Technologies, Cell Signaling Technology Inc., Dyadic International, Amresco LLC, Abcam plc, Bio Basic Inc., BioChain Institute Inc., BioLegend Inc., Bio-Rad Laboratories Inc., Enzo Life Sciences Inc., GenScript Biotech Corporation.
North America was the largest region in the global proteinase k market in 2024. Asia-Pacific is expected to be the fastest-growing region in the global proteinase k market during the forecast period. The regions covered in the proteinase k market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the proteinase k market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
Proteinase K, a serine protease derived from the mold Tritirachium album, serves as a valuable enzyme for the deactivation of protein contaminants in sample preparations. Widely utilized in DNA extraction processes, this enzyme comes in two primary forms lyophilized powder and liquid.
The lyophilized powder form is obtained through a dehydration process involving freezing and vacuum removal of water. Proteinase K finds applications across various therapeutic areas such as infectious diseases, diabetes, oncology, cardiology, nephrology, autoimmune diseases, and neurology. Its uses extend to isolation and purification of genomic DNA and RNA, in situ hybridization, mitochondria isolation, and enzyme removal.Target customers for Proteinase K include contract research organizations, academic institutes, biotechnology companies, and diagnostics laboratories. Its role in facilitating the efficient processing of samples makes it a key component in research and diagnostic workflows within the specified industries and applications.
The proteinase k market research report is one of a series of new reports that provides proteinase k market statistics, including proteinase k industry global market size, regional shares, competitors with a proteinase k market share, detailed proteinase k market segments, market trends and opportunities, and any further data you may need to thrive in the proteinase k industry. This proteinase k market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The proteinase K market consists of sales of acid proteinase, neutral proteinase, and alkaline proteinase. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
This product will be delivered within 3-5 business days.
The proteinase K market size is expected to see rapid growth in the next few years. It will grow to $8.19 billion in 2029 at a compound annual growth rate (CAGR) of 11.2%. The growth in the forecast period can be attributed to continued growth in molecular diagnostics, advancements in precision medicine, biopharmaceutical manufacturing expansion, research in proteomics and genomics, and increased application in forensic sciences. Major trends in the forecast period include pharmaceutical industry growth, technological advancements, market competition and pricing, sustainable and animal-free variants, and global pandemic impact.
The anticipated growth of the proteinase K market is expected to be driven by the increasing prevalence of chronic diseases. Chronic diseases, lasting more than a year and requiring continuous medical treatment, are a significant target for proteinase K usage. The enzyme plays a crucial role in both preventative and therapeutic applications, facilitating the extraction and isolation of DNA and RNA from viruses associated with various chronic diseases. For instance, data from the National Library of Medicine in January 2023 projected a rise in the number of individuals aged 50 and older with at least one chronic condition in the US, reaching 142.66 million by 2050. This underscores the growing significance of proteinase K in addressing the needs of a population grappling with chronic diseases.
The rising incidence of infectious diseases, particularly tuberculosis, is projected to drive growth in the proteinase K market in the future. Tuberculosis (TB) is a bacterial infection caused by Mycobacterium tuberculosis, which primarily affects the lungs but can also impact other areas of the body. Proteinase K is used in TB research for the extraction and isolation of DNA and RNA from the Mycobacterium tuberculosis bacterium. For example, in February 2024, the UK government department GOV.UK reported a 10.7% increase in tuberculosis cases in England in 2023, rising from 4,380 in 2022 to 4,850. Thus, the growing incidence of infectious diseases like tuberculosis is expected to boost the proteinase K market.
The proteinase K market is witnessing a notable trend towards product innovation, with major companies actively launching novel products to strengthen their positions. One such example is Biocatalysts Ltd., a UK-based biotechnology company, which introduced Proteocut K. This high-quality and cost-effective alternative to liquid proteinase K is a subtilisin-type serine protease with broad substrate specificity, suitable for a variety of life science applications. Its efficient hydrolysis of various proteins is attributed to its broad pH profile (6 - 10.0) and temperature range (40 -70°C). This innovative offering enhances the choices available in the proteinase K market, providing users with a versatile enzyme solution.
Companies are focused on continuous product development to stay competitive. ArcticZymes Technologies ASA, a Norway-based biotechnology company, exemplifies this by upscaling production and launching a glycerol-free version of ArcticZymes Proteinase. Known for its high activity and stability, this enzyme is valuable in molecular biology protocols, diagnostics, and bioprocessing. The glycerol-free variant offers enhanced stability at -20°C for up to one year, making it suitable for lyophilization and automated processes.
In January 2023, Lighthouse Pharma, a US-based biopharmaceutical company, acquired the small molecule proteinase inhibitor portfolio from Quince Therapeutics Inc. This acquisition positions Lighthouse Pharma to advance the development of gingipain inhibitors for dementia and other disorders, offering innovative treatment options. Quince Therapeutics Inc., a US-based biotechnology company specializing in proteinase inhibitors, contributes valuable assets to Lighthouse Pharma's research and development efforts.
Major companies operating in the proteinase K market include Merck KGaA, QIAGEN NV, Thermo Fisher Scientific Inc., F Hoffmann-La Roche Ltd., Worthington Biochemical Corporation, Sigma-Aldrich Co. LLC, Behemoth Inteligencia para os Negocios LTDA, Codexis Inc., Beijing SBS Genetech Co. Ltd, Hoffmann-La Roche Ltd, Amicogen Inc, Amano Enzyme Inc., Sisco Research Laboratories Pvt. Ltd., Promega Corporation, Bioline Diagnostics LLP, Biocompare, BioVision Inc., Creative Enzymes, G-Biosciences, Advanced Enzymes Technologies, Cell Signaling Technology Inc., Dyadic International, Amresco LLC, Abcam plc, Bio Basic Inc., BioChain Institute Inc., BioLegend Inc., Bio-Rad Laboratories Inc., Enzo Life Sciences Inc., GenScript Biotech Corporation.
North America was the largest region in the global proteinase k market in 2024. Asia-Pacific is expected to be the fastest-growing region in the global proteinase k market during the forecast period. The regions covered in the proteinase k market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the proteinase k market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
Proteinase K, a serine protease derived from the mold Tritirachium album, serves as a valuable enzyme for the deactivation of protein contaminants in sample preparations. Widely utilized in DNA extraction processes, this enzyme comes in two primary forms lyophilized powder and liquid.
The lyophilized powder form is obtained through a dehydration process involving freezing and vacuum removal of water. Proteinase K finds applications across various therapeutic areas such as infectious diseases, diabetes, oncology, cardiology, nephrology, autoimmune diseases, and neurology. Its uses extend to isolation and purification of genomic DNA and RNA, in situ hybridization, mitochondria isolation, and enzyme removal.Target customers for Proteinase K include contract research organizations, academic institutes, biotechnology companies, and diagnostics laboratories. Its role in facilitating the efficient processing of samples makes it a key component in research and diagnostic workflows within the specified industries and applications.
The proteinase k market research report is one of a series of new reports that provides proteinase k market statistics, including proteinase k industry global market size, regional shares, competitors with a proteinase k market share, detailed proteinase k market segments, market trends and opportunities, and any further data you may need to thrive in the proteinase k industry. This proteinase k market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The proteinase K market consists of sales of acid proteinase, neutral proteinase, and alkaline proteinase. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
This product will be delivered within 3-5 business days.
Table of Contents
1. Executive Summary2. Proteinase K Market Characteristics3. Proteinase K Market Trends and Strategies4. Proteinase K Market - Macro Economic Scenario including the impact of Interest Rates, Inflation, Geopolitics and Covid and Recovery on the Market32. Global Proteinase K Market Competitive Benchmarking and Dashboard33. Key Mergers and Acquisitions in the Proteinase K Market34. Recent Developments in the Proteinase K Market
5. Global Proteinase K Growth Analysis and Strategic Analysis Framework
6. Proteinase K Market Segmentation
7. Proteinase K Market Regional and Country Analysis
8. Asia-Pacific Proteinase K Market
9. China Proteinase K Market
10. India Proteinase K Market
11. Japan Proteinase K Market
12. Australia Proteinase K Market
13. Indonesia Proteinase K Market
14. South Korea Proteinase K Market
15. Western Europe Proteinase K Market
16. UK Proteinase K Market
17. Germany Proteinase K Market
18. France Proteinase K Market
19. Italy Proteinase K Market
20. Spain Proteinase K Market
21. Eastern Europe Proteinase K Market
22. Russia Proteinase K Market
23. North America Proteinase K Market
24. USA Proteinase K Market
25. Canada Proteinase K Market
26. South America Proteinase K Market
27. Brazil Proteinase K Market
28. Middle East Proteinase K Market
29. Africa Proteinase K Market
30. Proteinase K Market Competitive Landscape and Company Profiles
31. Proteinase K Market Other Major and Innovative Companies
35. Proteinase K Market High Potential Countries, Segments and Strategies
36. Appendix
Executive Summary
Proteinase K Global Market Report 2025 provides strategists, marketers and senior management with the critical information they need to assess the market.This report focuses on proteinase k market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
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Description
Where is the largest and fastest growing market for proteinase k? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The proteinase k market global report answers all these questions and many more.The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market’s historic and forecast market growth by geography.
- The market characteristics section of the report defines and explains the market.
- The market size section gives the market size ($b) covering both the historic growth of the market, and forecasting its development.
- The forecasts are made after considering the major factors currently impacting the market. These include:
- The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.
- Market segmentations break down the market into sub markets.
- The regional and country breakdowns section gives an analysis of the market in each geography and the size of the market by geography and compares their historic and forecast growth. It covers the growth trajectory of COVID-19 for all regions, key developed countries and major emerging markets.
- The competitive landscape chapter gives a description of the competitive nature of the market, market shares, and a description of the leading companies. Key financial deals which have shaped the market in recent years are identified.
- The trends and strategies section analyses the shape of the market as it emerges from the crisis and suggests how companies can grow as the market recovers.
Scope
Markets Covered:
1) By Form: Lyophilized Powder Form; Liquid Form2) By Therapeutic Area: Infectious Diseases; Diabetes; Oncology; Cardiology; Nephrology; Autoimmune Diseases; Neurology; Other Therapeutic Areas
3) By Application: Isolation and Purification of Genomic DNA and RNA; in Situ Hybridization; Mitochondria Isolation; Enzyme Removal
4) By End-Use: Contract Research Organization; Academic Institutes; Biotechnology Companies; Diagnostic Laboratories
Subsegments:
1) By Lyophilized Powder Form: High Purity Lyophilized Powder; Standard Grade Lyophilized Powder2) By Liquid Form: Ready-To-Use Liquid; Concentrated Liquid Solutions
Key Companies Mentioned: Merck KGaA; QIAGEN NV; Thermo Fisher Scientific Inc.; F Hoffmann-La Roche Ltd.; Worthington Biochemical Corporation
Countries: Australia; Brazil; China; France; Germany; India; Indonesia; Japan; Russia; South Korea; UK; USA; Canada; Italy; Spain
Regions: Asia-Pacific; Western Europe; Eastern Europe; North America; South America; Middle East; Africa
Time Series: Five years historic and ten years forecast.
Data: Ratios of market size and growth to related markets, GDP proportions, expenditure per capita.
Data Segmentation: Country and regional historic and forecast data, market share of competitors, market segments.
Sourcing and Referencing: Data and analysis throughout the report is sourced using end notes.
Delivery Format: PDF, Word and Excel Data Dashboard.
Companies Mentioned
- Merck KGaA
- QIAGEN NV
- Thermo Fisher Scientific Inc.
- F Hoffmann-La Roche Ltd.
- Worthington Biochemical Corporation
- Sigma-Aldrich Co. LLC
- Behemoth Inteligencia para os Negocios LTDA
- Codexis Inc.
- Beijing SBS Genetech Co. Ltd
- Hoffmann-La Roche Ltd
- Amicogen Inc
- Amano Enzyme Inc.
- Sisco Research Laboratories Pvt. Ltd.
- Promega Corporation
- Bioline Diagnostics LLP
- Biocompare
- BioVision Inc.
- Creative Enzymes
- G-Biosciences
- Advanced Enzymes Technologies
- Cell Signaling Technology Inc.
- Dyadic International
- Amresco LLC
- Abcam plc
- Bio Basic Inc.
- BioChain Institute Inc.
- BioLegend Inc.
- Bio-Rad Laboratories Inc.
- Enzo Life Sciences Inc.
- GenScript Biotech Corporation
Table Information
| Report Attribute | Details |
|---|---|
| No. of Pages | 200 |
| Published | February 2025 |
| Forecast Period | 2025 - 2029 |
| Estimated Market Value ( USD | $ 5.36 Billion |
| Forecasted Market Value ( USD | $ 8.19 Billion |
| Compound Annual Growth Rate | 11.2% |
| Regions Covered | Global |
| No. of Companies Mentioned | 30 |
