The Biology of Disease provides a comprehensive overview of the principles of the disease process. Building on the success of previous editions, this all-new Third Edition reflects the unprecedented challenges that the global community now faces in the field, as well as advances in the basic sciences of cell biology, immunology, and the molecular mechanisms of disease, with all chapters extensively modified to ensure that they remain at the cutting edge of current knowledge.
Each section is followed by case studies which bridge the gap between theory and clinical practice. This Third Edition includes 72 case studies in total, of which 34 are new. All diagrams and figures have been updated to present the most relevant information at a glance, and a new companion website with more than 500 multiple choice questions in two difficulty levels has been made available.
Written by three highly qualified academics with significant experience in the field, The Biology of Disease includes information on: - Emergence of new and drug resistant pathogens and an increasing recognition of the environmental factors, including climate change, that influence health- The growing impact of diet and physical inactivity on the development of obesity and related disorders including cancer and type 2 diabetes- Principles of epidemiology, cell reproduction, injury and death, inflammation and disorders of immunity- Disorders of blood and blood vessels including anaemia, vascular disorders, and disorders of haemostasis
The Biology of Disease is an essential textbook resource for medical students with a focus in physiology, pathophysiology, or pharmacology, along with undergraduate students in biomedical science, biomedicine, medical biochemistry, and human biology.
Table of Contents
List of Contributors vii
Contributors to Previous Editions xi
Preface to the Third Edition xiii
Preface to the Second Edition xv
Preface to the First Edition xvii
About the Companion Website xix
Part 1 Basic Principles of Disease and Epidemiology 1
1 The Nature of Disease 3
2 Principles of Epidemiology 11
Part 2 Cell Reproduction, Injury, and Death 29
3 Cell Reproduction, Injury, and Death 31
Part 3 Infectious Diseases 47
4 Infectious Diseases 49
Part 4 Inflammation and Disorders of Immunity 89
5 Inflammation and Repair 91
6 Disorders of the Immune System 109
Part 5 Disorders of Blood and Blood Vessels 155
7 Anaemia 157
8 Disorders of Haemostasis 169
9 Vascular Disorders 181
Part 6 Genetic Disorders 191
10 Genetic Disorders 193
Part 7 Neoplasia 213
11 Neoplasia 215
Part 8 Obesity, Diabetes, and Environmental Diseases 239
12 Nutritional Disorders and Obesity 241
13 Diabetes 257
14 Toxicology and Environmental Diseases 287
Case Studies 301
Answers 537
Appendix 1: Reference Ranges 567
Index 571