Unresectable Hepatocellular Carcinoma Global Market Report 2024

The unresectable hepatocellular carcinoma market size has grown rapidly in recent years. It will grow from $1.75 billion in 2023 to $1.96 billion in 2024 at a compound annual growth rate (CAGR) of 11.9%. The expansion observed in the historical period can be attributed to advances in chemotherapy, positive outcomes from clinical trials, limitations in liver transplantation, an increase in cancer cases, and the expanded access to therapies.

The unresectable hepatocellular carcinoma market size is expected to see strong growth in the next few years. It will grow to $2.64 billion in 2028 at a compound annual growth rate (CAGR) of 7.7%. The anticipated growth in the forecast period can be attributed to changes in healthcare policies, the implementation of patient stratification strategies, the utilization of real-world evidence, increased patient advocacy and awareness, and economic dynamics. Prominent trends expected during the forecast period include the prominence of precision medicine and biomarkers, the integration of real-world evidence and data, the adoption of multidisciplinary approaches, the expansion of global clinical trials and collaborations, and a shift towards patient-centric care.

The rise in the prevalence of liver cancer is poised to propel the growth of the market for unresectable hepatocellular carcinoma. Liver cancer occurs when tumor cells uncontrollably develop, taking over the healthy, functioning cells of the liver. Unresectable hepatocellular carcinoma is a form of cancer typically treated through methods such as liver transplantation and radiofrequency ablation. Globally, a significant number of lives, approximately 830,200, were lost to liver cancer in 2020, and projections indicate an anticipated 55.0% increase in new cases annually, with around 1.4 million new cases expected between 2020 and 2040. Furthermore, an estimated 1.3 million people are projected to succumb to liver cancer in 2040, representing a 56.4% increase compared to 2020. Thus, the escalating prevalence of liver cancer is a driving force behind the expansion of the unresectable hepatocellular carcinoma market.

The growth in healthcare expenditure is anticipated to drive the unresectable hepatocellular carcinoma market forward. Healthcare expenditure encompasses the total financial resources allocated to activities aimed at promoting, restoring, and maintaining health. As unresectable hepatocellular carcinoma progresses and becomes more complex, treatment options tend to become costlier. For example, in 2021, health spending experienced an average increase of approximately 6%, while a report by JPMorgan Chase & Co. in May 2022 revealed an overall 23% surge in healthcare spending in the same year. The growing healthcare expenditure is expected to be a significant driver in the expansion of the unresectable hepatocellular carcinoma market.

The upward trend in beer consumption is anticipated to fuel the growth of the unresectable hepatocellular carcinoma market. Beer consumption refers to the act of consuming beverages containing ethyl alcohol, specifically beer. Excessive alcohol consumption, including beer, is a well-known risk factor for hepatocellular carcinoma. Chronic alcohol intake can lead to liver cell damage, inflammation, fibrosis, and ultimately cirrhosis, creating conditions favorable for the development of hepatocellular carcinoma. The Global Beer Consumption Report for 2021, released by Kirin Holdings Company Limited, reported a global consumption of about 185.60 million kiloliters of beer in 2021, reflecting a 4.0% increase from the previous year. The growing consumption of beer is thus contributing to the expansion of the unresectable hepatocellular carcinoma market.

Innovations in products emerge as a notable trend gaining traction in the unresectable hepatocellular carcinoma market. Major companies operating in this market are actively pursuing the development of innovative products to maintain their market positions. For instance, AstraZeneca, a pharmaceutical and biotechnology company based in the UK, introduced Imjudo (tremelimumab) in combination with Imfinzi for unresectable liver cancer. This treatment, known as the STRIDE regimen, involves a single dose of anti-CTLA-4 antibody Imjudo 300mg combined with anti-PD-L1 antibody Imfinzi 1500 mg every four weeks. Patients receiving this combination showed a 22% lower chance of mortality compared to those receiving sorafenib.

Major players in the unresectable hepatocellular carcinoma market are focusing on the development of combination therapies to address the complexities of this condition. For example, Ono Pharmaceutical Co., Ltd., a pharmaceutical company based in Japan, launched Opdivo (nivolumab) Intravenous Infusion in combination with Yervoy in March 2023. Opdivo, a human anti-human PD-1 monoclonal antibody, works by blocking the interaction between PD-1 on T cells and its ligands on cancer cells, thereby enhancing T cells' ability to recognize and eliminate cancer cells more effectively. This development reflects the commitment of major companies to provide effective therapeutic options for unresectable hepatocellular carcinoma conditions.

Major companies operating in the unresectable hepatocellular carcinoma market report are Pfizer Inc., Johnson & Johnson Private Limited, F Hoffmann-La Roche Ltd., Merck & Co Inc., Bayer AG, Bristol-Myers-Squibb Company, Astrazeneca PLC, Takeda Pharmaceutical Company Limited, Eli Lilly and Company, Amgen Inc., Regeneron Pharmaceuticals Inc., Chugai Pharmaceutical Co Ltd., Eisai Co. Ltd., Ipsen S.A., Jiangsu HengRui Medicine Co. Ltd., Exelixis Inc., BeiGene Ltd., Halozyme Therapeutics Inc., Innovent Biologics Inc., Sirtex Medical Limited, Blueprint Medicines Corporation, Genentech Inc., CStone Pharmaceuticals, Pharmicell Co. Ltd., Pharmaxis Ltd., Delcath Systems Inc., Yiviva Inc., Celsion Corporation, Mendus AB.

North America was the largest region in the unresectable hepatocellular carcinoma market in 2023. The regions covered in the unresectable hepatocellular carcinoma market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the unresectable hepatocellular carcinoma market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

The main types of unresectable hepatocellular carcinoma are primary, secondary, and benign liver growth. In this context, 'primary' signifies a greater significance, and as the most prevalent form of primary liver cancer, hepatocellular carcinoma is particularly noteworthy. Various treatment approaches, such as chemotherapy, molecularly targeted therapy, immunotherapy, and others, are employed in hospitals, specialty clinics, and cancer centers.

The unresectable hepatocellular carcinoma market research report is one of a series of new reports that provides unresectable hepatocellular carcinoma market statistics, including unresectable hepatocellular carcinoma industry global market size, regional shares, competitors with a unresectable hepatocellular carcinoma market share, detailed unresectable hepatocellular carcinoma market segments, market trends and opportunities, and any further data you may need to thrive in the unresectable hepatocellular carcinoma industry. This unresectable hepatocellular carcinoma market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The unresectable hepatocellular carcinoma market includes revenues earned by entities by providing first-line agents, surgical resection, and liver transplant. The market value includes the value of related goods sold by the service provider or included within the service offering. Only goods and services traded between entities or sold to end consumers are included.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.


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