Principles of Immunotherapy in Breast and Gastrointestinal Cancers: Activity, Mechanisms of Resistance, and New Sensitization Strategies presents updated research findings on immunotherapy, with a special focus on the mechanisms of resistance of those cancer types and how to overcome them. The book discusses topics such as tumor cell-intrinsic and -extrinsic mechanisms of cancer resistance to immunotherapy; the role of currently available biomarkers; strategies to overcome therapeutic resistance; sensitizing agents for cancer resistance to cell-mediated immunotherapy; and immunotherapeutic approaches, mechanisms of resistance, and sensitizing strategies in gastroesophageal and biliopancreatic tumors and colorectal cancer. It is a valuable resource for researchers, students, and members of the biomedical and medical fields who want to learn more about resistance to immunotherapy and how to overcome it.
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Table of Contents
1. Mechanisms of resistance to immunotherapy2. Biomaker-based immunotherapy in breast cancer
3. Immunotherapy for breast cancer: new strategies to enhance the patient selection and overcome therapeutic resistance
4. Sensitizing Agents for Cancer Resistance to Cell Mediated Immunotherapy in the GI tract
5. Immunotherapeutic approaches, mechanisms of resistance and sensitizing strategies in gastroesophageal tumors
6. Immunotherapeutic approaches, mechanisms of resistance and sensitizing strategies in biliopancreatic tumours
7. Immunotherapeutic approaches, mechanisms of resistance and sensitizing strategies in colorectal cancer
8. Concluding remarks and future perspectives
Authors
Michele Ghidini Medical Oncologist, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, Milano, Italy.Michele Ghidini is a Medical Oncologist working in the Operative Unit of Oncology of Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico in Milan, Italy. He is the one responsible for the clinical and research activities in the field of gastrointestinal tumors. From 2007 till now, he has followed clinical and translational studies mainly concerning biliopancreatic, gastric, and colorectal cancers. Between September 2014 and June 2015, he was a research fellow at the Institute of Cancer Research/Royal Marsden Hospital (London, UK) in the Gastrointestinal Cancer Biology and Genomics Team, and he mainly focused on the role of liquid biopsies in metastatic colorectal cancer. He holds a PhD degree in medical sciences from the University of Parma with a dissertation on the prognostic and predictive roles of liquid biopsies in advanced colorectal carcinoma. He is main author, corresponding or co-author of more of 180 scientific papers indexed on Pubmed and Scopus and works as associate editor for the oncology section of Cell Press journal Helyion. He is member of national and international working groups in the field of oncology such as ESMO, EORTC and AIOM.
