Biochemical Immunology of Diabetes and Associated Complications offers in-depth coverage of the association of biochemical and immunological aspects of the human body in diabetes. It discusses the suppression and modulation of the immune system and the impact of immunochemicals on the biochemical pathways in diabetes, along with associated complications. The book enumerates the exigency in knowledge about the immunomodulators as therapeutic targets to cure the syndrome. It will serve as an important reference for medical practitioners, researchers, medical students, masters and doctoral students. In addition, it could also be used as a reference for science graduates, science teachers, and researchers.
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Table of Contents
1. Types of Diabetes, mechanism of insulin resistance and associated complications 2. Introduction to Immunology 3. Immune system and diabetes 4. Type-2 diabetes and its effect on immune system 5. Association of oxidative stress with diabetes 6. Biochemical pathways involved in diabetes 7. Immune response and biochemical connection in diabetes 8. immunomodulation and mitigation of diabetic complications 9. Targeting immune system for the treatment of diabetes 10. Inflammatory-mediated responses in development of diabetes 11. Gut-Microbiota-Brain Axis: pathophysiological mechanism in diabetes 12. Association of diabetes mellitus with stress, neuroinflammation other comorbid neuropsychiatric disorders 13. C-reactive protein: a potent inflammatory biomarker in insulin resistance 14. Anti-inflammatory therapy as a promising target for the treatment of diabetes mellitus 15. Role of symbiotic in the treatment of diabetes mellitus via modification of immune system 16. Effect of current antidiabetic drugs on inflammation and immune system 17. Nutraceuticals targeting immune system for the treatment of diabetes 18. Impact of herbal drugs on immune system and diabetes 19. Case studies related to the diseases in question 20. Future Targets
Authors
Pratima Tripathi Assistant Professor, Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Sarojini Nagar, Lucknow (UP), India.Currently Dr. Pratima is serving as an Assistant Professor in the Department of Biotechnology at National Institute of Pharmaceutical Education and Research (NIPER), Raebareli. Pratima earned her Ph.D. in Biochemistry from University of Lucknow, Lucknow, Uttar Pradesh in 2012. Her doctoral research oriented on 'Therapeutic Role of L-arginine on free radical scavenging system in ischemic heart diseases.' During her research, she investigated the vivid role of L-arginine as a significant therapeutic in mitigating the oxidant-antioxidant imbalance that arises during oxidative stress condition and oxygen insult that contributes in the pathogenesis of myocardial infarction induced ischemia and further complications. She contributed her research outputs as publications in high impact journals of repute. The scholar has also been bestowed with 'Young Scientist Award' in 2010 from the Society for Immunology and Immunopathology, India.
She had a stint teaching experience in Sri Sathya Sai Institute of Higher Learning (SSSIHL), Anantapur as an Assistant Professor from 2012 to 2017. After gaining a rich experience in Southern India, she relocated to her home town, Lucknow and served as Guest faculty at Integral University, Lucknow till May 2019.
The dynamic phase of her academic career and her zeal towards scientific research granted her a good opportunity as ICMR-Research associateship and Principal Investigator on the project "The role of highly sensitive Troponin-I, highly sensitive C Reactive Protein and NT-proBNP in predicting coronary artery stenosis in patients undergoing Coronary Artery Angiography.�
The ICMR research project was focused on biomarker profiling and analysis of different cardiac and inflammatory biomarkers in coronary artery disease patients to investigate the correlation between the extent of vascular stenosis and level of biomarkers. Research outcome from the work conducted by Pratima as Postdoctoral fellow at Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow from 2019 to 2021 was utilized for setting up hs-TnI as a profiling marker at DRMLIMS in 2021 as is currently a part of routine blood test for all the CVD patients at DRMLIMS and associated clinical setups.
In 2021, she joined National Institute of Pharmaceutical Education and Research (NIPER), Raebareli as an Assistant Professor in the Department of Biotechnology. The institute offered her acumen a good scope in both academic cum administrative aspects with a magnified research spectrum. Her research team works in the area of pharmaceutical biotechnology and is focused on drug discovery and development. The team formulated nanocarriers and drug conjugates for efficient transport of drugs; artemisinin and berginin and studied the impact of these formulations in mitigating diabetes induced inflammatory complications.
Rama Pati Tripathi Adjunct Professor, Mody University, Lakhsmangarh, Rajasthan and NIPER Raibarely, India, Ex-Professor, AcSIR & Retired Chief Scientist, CSIR-Central Drug Research Institute India. Dr. Rama Pati Tripathi has over 40 years of research and teaching experience, supervised more than 70 students, published more than 150 research papers in international journals of high repute and high impact journals, more than 20 patents and 100 invited talks in national and international conferences in India and abroad. He has been accoladed with several prestigious awards to name a few being INSA Visiting Scientist Fellowship, First eTCR award 2009 by Association of Carbohydrate Chemists and Technologists of India, Elected Fellow of Association of Carbohydrate Chemists and Technologists of India, 2014, Life Time Achievement Award by ACCTI in 2016. Dr. Tripathi is also the Life member of Indian Chemical Society, Indian medicinal chemists association, UP association of advancement of science and technology, Society of biological chemists of India, Fellow, Association of carbohydrate Chemists and Technologists of India, Association of Carbohydrate Chemists & Technologists of India. Mahabir Parshad Kaushik Pro Vice Chancellor and Dean Research Former Director Defence Research & Development Establishment Gwalior & Programe Director (NBC) DRDO Delhi. Amity University Madhya Pradesh Maharajpura Dang, Gwalior (MP) India. Dr. Kaushik travelled extensively on delegations to different parts of the world including the USA, Finland, Sweden, Germany, France, UK, Tunisia, Czech Republic and Switzerland (Geneva). He has been awarded several prestigious awards and honors. A few to mention are: DRDO Cash Award, Defence Technology Spin off Award, National Technology Award, Technology Group Award (DRDO), Scientist of the Year Award (DRDO) and Agni award for self-Reliance. Dr. Kaushik has a rich academic background and has taught at MITS Gwalior, as well as Utah State University, Logan, USA. He has published ~ 181 articles, has 20 Patents and 09 technology transfers. Prof (Dr) M P Kaushik, the Pro Vice Chancellor of Amity University Madhya Pradesh is a Scientist and Administrator of eminence, who had an illustrious tenure at Defence Research and Development Establishment, Govt of India, from where he superannuated as Director and Outstanding Scientist (SC 'H').
