Engineering Biology for Microbial Biosynthesis of Plant-Derived Bioactive Compounds will be of great interest to undergraduate and graduate students, scientists, researchers, and engineers who work on the microbial production of plant-derived bioactive compounds. As many plant-derived bioactive compounds are the foundation of effective drugs to cure diseases, it's important to understand the limits of their applications in drugs and other industries. With the development of synthetic biology and green biomanufacturing, the biosynthesis of complex bioactive compounds is possible. However, the engineering fundamentals for microbial biosynthetic of plant-derived bioactive compounds is vast. This book summarizes the engineering fundamental biotechnologies for microbial production of plant-derived bioactive compounds, allowing the content to be easily accessed. Coverage includes summaries of key achievements, identification of challenges, current approaches, tips and tricks, and helpful insights into critical bottlenecks.
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Table of Contents
1. Mining bioparts for the biosynthesis of plant-derived bioactive compounds via omics and bioinformatics technologies Zheyong Xue, Yanlin Li, Xue Yin, Yanhong Guo and Jia Liu 2. DNA assembly techniques for the reconstitution of plant natural product biosynthetic pathways in Saccharomyces cerevisiae Jiazhang Lian 3. The application of gene-editing technologies in the biosynthesis of plant-derived bioactive compounds Xin Sun, Meng Li, Yiting Mei and Meirong Jia 4. Pathway engineering of plant-derived bioactive compounds in microbes Yun Liu, Dadeng Zhang, Tongjian Yang, Ruidong Chen and Xiaozhou Luo 5. Construction and application of a genome-scale metabolic network model for plants Jinyi Qian and Chao Ye 6. Metabolic design-build-test-learn cycle used for the biosynthesis of plant-derived bioactive compounds Yongkun Lv and Weigao Wang 7. Microbial cell factories for the synthesis of plant-derived bioactive compounds: metabolic flux dynamic regulation Yameng Xu, Xiaoyang Ge, Ximan Hu, Xinrui Chen, Zhitian Zhang and Yonglin Zhang 8. Yeast cell factories for the biosynthesis of plant-derived bioactive terpenoids Yapeng Zhang and Chun Li 9. Nonconventional yeast cell factories for the biosynthesis of plant-derived bioactive terpenoids Qi Guo and Tian-Qiong Shi 10. Nonconventional yeast cell factories for the biosynthesis of plant-derived bioactive flavonoids Lin Hu, Liuheng Huang, Huihui Qiu, Fenghui Zhang, W.H. Nishani De Soyza, Ning He and Mingfeng Cao 11. Non-yeast fungal cell factories for the biosynthesis of plant-derived bioactive compounds Gen Zou 12. Fine-tuning and dynamic control of microbial cell factories for the biosynthesis of plant-derived bioactive compounds Lidan Ye 13. Biofoundries for plant-derived bioactive compounds Lihang Xie 14. Engineering biology fundamental for plant-derived bioactive compounds: challenges and prospects Ruibing Chen and Lei Zhang 15. Reprogramming microbial cell factories to overproduce plant natural products through directed genome evolution Zhihui Shi and Guokun Wang
Authors
Yongjun Wei School of Pharmaceutical Sciences, Laboratory of Synthetic Biology, Food Laboratory of Zhongyuan, Zhengzhou University, Zhengzhou, China. Dr. Yongjun Wei, PhD, completed his bachelor's degree in biology at Shaanxi Normal University, China, before pursuing his PhD in microbiology from the Chinese Academy of Sciences (CAS) in 2014. Following his doctoral studies, he conducted a postdoctoral fellowship at the Chalmers University of Technology from 2014 to 2016. After that, he worked as an assistant researcher at CAS for a year before joining Zhengzhou University's faculty in 2018. Currently he serves as an associate professor at Zhengzhou University, Dr. Wei has published over 80 peer-reviewed papers and holds more than 20 patents. Furthermore, he serves as an editorial board member or youth editor for over 10 different journals. His research primarily focuses on microbial production of plant bioactive natural products and the utilization of microorganisms for disease treatment and pollution eradication. Xiao-Jun Ji NanjingTech University, National Engineering Research Centre for Biotechnology , Nanjing, China. Dr. Xiao-Jun Ji, PhD, is currently a professor of bioengineering and biochemical engineering at Nanjing Tech University (NanjingTech), China. He received his BSc and PhD degrees from NanjingTech in 2005 and 2009 and conducted the visiting research in the Systems and Synthetic Biology lab headed by Prof. Jens Nielsen at Chalmers, Sweden during 2016 and 2017. His recent research focuses on biomanufacturing pharmaceutical and nutritional chemicals using the nonconventional yeasts through the metabolic engineering and the emerging synthetic biology tools. He has many awards such as the Fok Ying-Tung Foundation Young Scholars Award (2014), the Hou De-Bang Chemical Youth Award of CIESC (2016), the National Technological Invention Award of China (2018), the Excellent Young Scholars of NSFC (2019), and the Newton Advanced Fellowships of the Royal Society (2020). Mingfeng Cao Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Key Laboratory for Synthetic Biotechnology of Xiamen City, Xiamen University, Xiamen, China.Dr. Mingfeng Cao, PhD, is the Minjiang distinguished professor in the Department of Chemical and Biochemical Engineering, the director of the Institute of Bioengineering, and an honorary research fellow of the Tan Kah Kee Innovation Laboratory at the Xiamen Laboratory, China. He was awarded his PhD from the Nankai University in 2011, and between 2011 and 2013 worked as a research associate at the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences. He completed postdoctoral studies at Iowa State University, USA and was a research scientist at the University of Illinois from 2018 to 2021. His research focuses on the development of synthetic biology and metabolic engineering strategies to establish microbial cell factories for value-added and green chemical production. Dr. Cao has published over 60 journal articles and holds 10 patents. He also serves as the editor-in-chief of Biotechnology Reports and the associate editor for journals such as Microbial Cell Factories and Biotechnology for Biofuels and Bioproducts.
