T Cell Metabolism and Cancer Immunotherapy delves into the intricate regulation of T-cell immunity and tolerance. As research advances in cell-based therapies, the potential of engineered immune cells to treat cancers and other diseases is becoming increasingly evident due to their powerful capabilities. Additionally, the book offers valuable insights into developing and optimizing strategies for bacterium-based immunotherapies. Despite great advancement in immunotherapy such as adoptive T cell transfer-based regimen, the clinical outcomes remain less satisfactory due to a variety of factors that lessen its therapeutic efficacy. By determining the role and importance of T cell metabolism in the regulation of T lymphocytes that are related to the development and managements of aberrant immunity, T Cell Metabolism and Cancer Immunotherapy designs and develops novel and more effective strategies for improving regimens for patients with aberrant immunity. Within ten chapters the content not only reveals targets of T cell metabolism as critical determinants of immune regulation, but also uncovers unique therapeutic opportunities to improve immunotherapy through targeting T cell metabolism. This fills a significant gap in the knowledge of scientists working in the field of onco-immunology/immunotherapy, and students learning about T cells, metabolism, immunomodulation, and immunotherapy.
Table of Contents
1. Modulating T cell metabolism to improve T cell therapy2. Links between the DNA damage response and immune response in cancer
3. Improving adoptive T cell therapy by positive conversion of negative signaling
4. TGF-� in tumor microenvironment, metabolism, and immunotherapy
5. Targeting Immunometabolism to Improve Cancer Therapies
6. TCR-T Cells for Cancer Immunotherapy
7. The Combination of Local Treatment and Immunotherapy
8. T cell metabolism and cancer immunotherapy
9. Exploring the Interplay of Kinases and Transcription Factors in Immunometabolism
10. Targeting Engineered Bacteria to Improve Cancer Immunotherapy
11. Salmonella: A Bacterial Warrior in Cancer Immunotherapy
12. Oncolytic Virus for Cancer Immunotherapy
13. Advances in Immunotherapy for Colorectal Cancer
Authors
Jianxun Song Texas A&M University Health Science Center, College Station, TX, United States. Dr. Song is Professor of Microbial Pathogenies and Immunology at Texas A&M University Health Science Center, Bryan, TXIs highly motivated to pursue an academic research career in Microbial Pathogenesis and Immunology. The base of expertise on T cell biology needed to perform the proposed research began to develop while he was a postdoctoral scholar and research scientist from the years 2000-2007 under the mentorship of Dr. Michael Croft at La Jolla Institute for Allergy & Immunology. As a PI on previous university-, foundation- and NIH-funded grants, he laid the groundwork for the proposed research by developing antigen-specific T lymphocytes from pluripotent stem cells.. He offered leadership and administrative skills that were developed during his independence as a mentor of graduate students and postdoctoral scholars.
