Oncolytic Virus Therapy Market Report 2025

The oncolytic virus therapy market size has grown exponentially in recent years. It will grow from $0.19 billion in 2024 to $0.23 billion in 2025 at a compound annual growth rate (CAGR) of 25.4%. The growth in the historic period can be attributed to improved genetic engineering techniques, increased understanding of tumor microenvironment, clinical successes and regulatory approvals, the rise of immunotherapy in cancer treatment, and advancements in gene delivery systems.

The oncolytic virus therapy market size is expected to see exponential growth in the next few years. It will grow to $0.55 billion in 2029 at a compound annual growth rate (CAGR) of 23.7%. The growth in the forecast period can be attributed to the expansion of oncolytic virus platforms, combination therapies with immune checkpoint inhibitors, personalized medicine approaches, expansion of the clinical trial landscape, regulatory support and guidelines. Major trends in the forecast period include technological advances in delivery systems, advancements in synthetic biology, collaborations and partnerships in the biopharmaceutical industry, advancements in virology and immunology, focus on pediatric oncology.

The escalating prevalence of cancer cases stands poised to drive the growth of the oncolytic virus therapy market. Cancer, a collective term for diseases characterized by uncontrolled cell growth, is a significant global health concern. Oncolytic virus therapy emerges as a promising approach, capable of selectively targeting and eliminating cancer cells while simultaneously triggering an immune response against tumors, providing a dual mechanism for effective cancer treatment. Notably, in January 2023, the American Cancer Society Inc. projected 609,820 cancer deaths and 1,958,310 new cancer cases in the United States for 2022. This stark reality underscores the urgent need for innovative therapeutic approaches, such as oncolytic virus therapy, to address the growing prevalence of cancer cases.

The oncolytic virus therapy market is expected to experience growth propelled by the increasing number of ongoing clinical trials. Clinical trials, essential research studies involving human participants, serve to assess the safety and efficacy of new medical treatments, interventions, or diagnostic procedures. The surge in clinical trials utilizing oncolytic virus therapy underscores the therapeutic potential of this approach, given its ability to selectively target cancer cells while sparing healthy tissue. As of October 2023, ClinicalTrials.gov reported a significant increase in registered studies, rising from 437,523 in 2022 to 468,457 across all 50 states of the United States and 221 countries. Notably, 143,613 studies (31% of the total) are registered in the U.S., with 251,159 studies (54% of the total) registered in non-U.S. locations. This proliferation of clinical trials signifies the growing interest and investment in oncolytic virus therapy as a promising avenue for cancer treatment, contributing to the market's expansion.

Major companies in the oncolytic virus therapy market are focused on securing regulatory approvals to accelerate the launch of innovative cancer treatments. Regulatory approvals refer to the procedure through which health authorities assess and authorize medical products, including drugs, biologics, and medical devices, for market use. For example, in March 2024, ImmVira, a biotechnology firm based in China, received Fast Track designation from the FDA for its oncolytic virus therapy, MVR-T3011 IT. This therapy is intended for patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) who have experienced disease progression after platinum-based chemotherapy and at least one prior line of anti-PD-1/PD-L1 therapy. The Fast Track designation aims to expedite the development and review process for therapies that address serious conditions with unmet medical needs.

Strategic partnerships play a pivotal role in advancing comprehensive cancer treatments within the oncolytic virus therapy industry. RenovoRx Inc., a US-based clinical-stage biopharmaceutical company, and Imugene Ltd., an Australia-based clinical-stage immuno-oncology company, forged a strategic research collaboration in July 2023. The aim of this partnership is to optimize the delivery of Imugene’s oncolytic virus therapy leveraging RenovoRx’s TAMP (Trans-Arterial Micro-Perfusion) therapy platform. Additionally, the collaboration seeks to explore the administration of Imugene’s CF33 oncolytic virus technology using RenovoRx’s TAMP therapy platform, with a specific focus on treating challenging-to-access tumors. This strategic alliance exemplifies the industry's commitment to collaborative efforts, driving advancements in oncolytic virus therapy for enhanced cancer treatment outcomes.

In April 2022, Recipharm AB, a pharmaceutical company based in Sweden, completed the acquisition of Vibalogics for an undisclosed sum. This strategic move enabled Recipharm AB to enhance its global presence significantly by integrating a comprehensive end-to-end portfolio encompassing development capabilities, GMP drug substance and drug product manufacturing, sterile fill & finish services, as well as analytical and quality control testing. Vibalogics, a German biotechnology firm and a Contract Development and Manufacturing Organization (CDMO), specializes in manufacturing oncolytic viruses, viral vaccines, and gene therapies.

Major companies operating in the oncolytic virus therapy market include Pfizer Inc., Johnson & Johnson, Sorrento Therapeutics Inc., AbbVie Inc., AstraZeneca plc, Amgen Inc., Boehringer Ingelheim Group, Regeneron Pharmaceuticals, Daiichi Sankyo Company Limited, Kissei Pharmaceutical Co. Ltd., Takara Bio Inc., Oncorus Inc., Replimune Inc., Vyriad Inc., Genelux Corporation, Oncolys BioPharma Inc., Adze Biotechnology, Oncolytics Biotech Inc., TILT Biotherapeutics Ltd., Transgene SA, Circio Holding ASA, Lokon Pharma AB, Provectus Biopharmaceuticals Inc., Vibalogics.

North America was the largest region in the oncolytic virus therapy market in 2024, and is expected to be the fastest-growing region in the forecast period. The regions covered in the oncolytic virus therapy market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the oncolytic virus therapy market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Italy, Spain, Canada.

Oncolytic virus therapy, also referred to as virotherapy, represents a cancer treatment approach employing viruses to selectively target and eliminate cancer cells within the body. The primary goal of this therapy is to leverage modified or naturally occurring viruses capable of infecting and replicating specifically within cancerous cells while preserving healthy cells.

The key categories of oncolytic virus therapy include HSV-based oncolytic virus therapy, adenovirus-based oncolytic virus therapy, reovirus, poxviruses, Newcastle disease virus (NDV), among others. HSV-based oncolytic virus therapy employs the herpes simplex virus (HSV) as the foundational component for treatment. Various virus types encompass genetically modified oncolytic viruses as well as oncolytic wild-type viruses. These therapies find application across different cancer types such as breast cancer, lung cancer, prostate cancer, melanoma, brain tumors, and blood cancer. They are utilized by healthcare institutions including hospitals, specialized clinics, and cancer research institutes.

The oncolytic virus therapy market research report is one of a series of new reports that provides oncolytic virus therapy market statistics, including oncolytic virus therapy industry global market size, regional shares, competitors with an oncolytic virus therapy market share, detailed oncolytic virus therapy market segments, market trends, and opportunities, and any further data you may need to thrive in the oncolytic virus therapy industry. This oncolytic virus therapy market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The oncolytic virus therapy market includes revenues earned by entities by providing seneca valley virus (SVV), semliki forest virus (SFV), vesicular stomatitis virus (VSV), and sindbis virus (SBV). The market value includes the value of related goods sold by the service provider or included within the service offering. Only goods and services traded between entities or sold to end consumers are included.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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