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Homozygous Familial Hypercholesterolemia Market - Global Industry Size, Share, Trends, Opportunity and Forecast, 2020-2030F- Product Image
Homozygous Familial Hypercholesterolemia Market - Global Industry Size, Share, Trends, Opportunity and Forecast, 2020-2030F- Product Image
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Homozygous Familial Hypercholesterolemia Market - Global Industry Size, Share, Trends, Opportunity and Forecast, 2020-2030F

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  • 184 Pages
  • April 2025
  • Region: Global
  • TechSci Research
  • ID: 5900034
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The Homozygous Familial Hypercholesterolemia Market was valued at USD 82.67 Million in 2024, and is expected to reach USD 103.97 Million by 2030, rising at a CAGR of 3.87%. This market is a vital segment within the broader pharmaceutical and healthcare sectors, focused on addressing the rare and severe genetic disorder known as Homozygous Familial Hypercholesterolemia. It is dedicated to the development, production, and distribution of therapeutic solutions aimed at managing and treating this genetic condition.

HoFH is an autosomal recessive disorder marked by abnormally high levels of low-density lipoprotein cholesterol (LDL-C) in the bloodstream, which leads to early and severe cardiovascular complications. Individuals affected by HoFH face significantly increased risks of heart attacks and other cardiovascular issues from a young age, necessitating lifelong, specialized medical care.

The HoFH market has seen significant growth in recent years, driven by breakthroughs in biotechnology, genetics, and pharmacology. Pharmaceutical leaders are actively investing in research and development to discover innovative therapies, such as monoclonal antibodies, gene therapies, and RNA-based treatments, to better manage and potentially cure this debilitating condition. These novel therapies show promise in dramatically lowering LDL-C levels and improving patients' quality of life.

Key Market Drivers

Advancements in Biotechnology and Genetics: Breakthroughs in biotechnology and genetics have been pivotal in propelling the growth of the HoFH market. Monoclonal antibodies like evinacumab (Evkeeza) have been instrumental in this progress. Approved by the U.S. FDA in February 2021, evinacumab inhibits angiopoietin-like 3 (ANGPTL3), a protein that obstructs lipid breakdown. By targeting ANGPTL3, evinacumab significantly reduces LDL-C levels in HoFH patients, decreasing the risk of cardiovascular complications. Clinical trials have confirmed its transformative potential in treating HoFH.

Key Market Challenges

High Development Costs: A major challenge facing the HoFH market is the high development costs associated with creating therapies for this ultra-rare genetic disorder. HoFH affects roughly 1 in a million individuals globally, resulting in a small and geographically dispersed patient population. This scarcity complicates clinical trial recruitment and raises costs related to patient participation and data collection. Additionally, the complex nature of HoFH requires extensive research and multi-phase clinical trials, further driving up development costs.

Key Market Trends

Telemedicine and Remote Monitoring: Telemedicine and remote monitoring technologies have become transformative in the management of HoFH, addressing the challenges posed by geographic and specialist access limitations. Telemedicine enables patients to consult with specialized healthcare providers remotely, ensuring timely and consistent care. Through telehealth platforms, healthcare professionals can monitor patient progress, suggest lifestyle changes, and adjust treatments as needed, reducing the need for in-person visits.

Furthermore, remote monitoring technologies, including wearable devices and mobile applications, allow patients to track their cholesterol levels, medication adherence, and overall health. This continuous monitoring provides healthcare providers with real-time data, allowing for prompt interventions and minimizing the risk of cardiovascular events.

These advancements highlight the dynamic nature of the HoFH market, with significant potential for growth driven by innovation in therapeutic treatments and healthcare delivery.

Key Market Players

  • AstraZeneca PLC
  • Viatris Inc.
  • Teva Pharmaceutical Industries Ltd.
  • Accord Healthcare
  • Changzhou Pharmaceutical Factory
  • Regeneron Pharmaceuticals, Inc.
  • Amryt Pharma plc
  • Amgen Inc.
  • Organon Global Inc.
  • CMP Pharma

Report Scope:

In this report, the Global Homozygous Familial Hypercholesterolemia Market has been segmented into the following categories, in addition to the industry trends which have also been detailed below:

Homozygous Familial Hypercholesterolemia Market, By Drug Class:

  • Statins
  • Cholesterol Absorption Inhibitors
  • PCSK9 Inhibitors
  • MTP Inhibitors
  • ANGPTL3 Inhibitors

Homozygous Familial Hypercholesterolemia Market, By Route of Administration:

  • Oral
  • Parenteral
  • Nasal

Homozygous Familial Hypercholesterolemia Market, By Technology:

  • CRISPR-Cas9
  • RNA Interference
  • Nanoparticle-Based Therapies

Homozygous Familial Hypercholesterolemia Market, By Distribution Channel:

  • Hospital Pharmacies
  • Retail Pharmacies
  • Online Pharmacies

Homozygous Familial Hypercholesterolemia Market, By Region:

  • North America
  • United States
  • Canada
  • Mexico
  • Europe
  • France
  • United Kingdom
  • Italy
  • Germany
  • Spain
  • Asia-Pacific
  • China
  • India
  • Japan
  • Australia
  • South Korea
  • South America
  • Brazil
  • Argentina
  • Colombia
  • Middle East & Africa
  • South Africa
  • Saudi Arabia
  • UAE

Competitive Landscape

Company Profiles: Detailed analysis of the major companies present in the Global Homozygous Familial Hypercholesterolemia Market.

Available Customizations:

With the given market data, the publisher offers customizations according to a company's specific needs. The following customization options are available for the report.

Company Information

  • Detailed analysis and profiling of additional market players (up to five).

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Table of Contents

1. Product Overview
1.1. Market Definition
1.2. Scope of the Market
1.2.1. Markets Covered
1.2.2. Years Considered for Study
1.2.3. Key Market Segmentations
2. Research Methodology
2.1. Objective of the Study
2.2. Baseline Methodology
2.3. Key Industry Partners
2.4. Major Association and Secondary Sources
2.5. Forecasting Methodology
2.6. Data Triangulation & Validation
2.7. Assumptions and Limitations
3. Executive Summary
3.1. Overview of the Market
3.2. Overview of Key Market Segmentations
3.3. Overview of Key Market Players
3.4. Overview of Key Regions/Countries
3.5. Overview of Market Drivers, Challenges, Trends
4. Global Homozygous Familial Hypercholesterolemia Market Outlook
4.1. Market Size & Forecast
4.1.1. By Value
4.2. Market Share & Forecast
4.2.1. By Drug Class (Statins, Cholesterol Absorption Inhibitors, PCSK9 Inhibitors, MTP Inhibitors, ANGPTL3 Inhibitors)
4.2.2. By Route of Administration (Oral, Parenteral, Nasal)
4.2.3. By Technology (CRISPR-Cas9, RNA Interference, Nanoparticle-Based Therapies)
4.2.4. By Distribution Channel (Hospital Pharmacies, Retail Pharmacies, Online Pharmacies)
4.2.5. By Region
4.2.6. By Company (2024)
4.3. Market Map
4.3.1. By Drug Class
4.3.2. By Route of Administration
4.3.3. By Technology
4.3.4. By Distribution Channel
4.3.5. By Region
5. Asia Pacific Homozygous Familial Hypercholesterolemia Market Outlook
5.1. Market Size & Forecast
5.1.1. By Value
5.2. Market Share & Forecast
5.2.1. By Drug Class
5.2.2. By Route of Administration
5.2.3. By Technology
5.2.4. By Distribution Channel
5.2.5. By Country
5.3. Asia Pacific: Country Analysis
5.3.1. China Homozygous Familial Hypercholesterolemia Market Outlook
5.3.1.1. Market Size & Forecast
5.3.1.1.1. By Value
5.3.1.2. Market Share & Forecast
5.3.1.2.1. By Drug Class
5.3.1.2.2. By Route of Administration
5.3.1.2.3. By Technology
5.3.1.2.4. By Distribution Channel
5.3.2. India Homozygous Familial Hypercholesterolemia Market Outlook
5.3.2.1. Market Size & Forecast
5.3.2.1.1. By Value
5.3.2.2. Market Share & Forecast
5.3.2.2.1. By Drug Class
5.3.2.2.2. By Route of Administration
5.3.2.2.3. By Technology
5.3.2.2.4. By Distribution Channel
5.3.3. Australia Homozygous Familial Hypercholesterolemia Market Outlook
5.3.3.1. Market Size & Forecast
5.3.3.1.1. By Value
5.3.3.2. Market Share & Forecast
5.3.3.2.1. By Drug Class
5.3.3.2.2. By Route of Administration
5.3.3.2.3. By Technology
5.3.3.2.4. By Distribution Channel
5.3.4. Japan Homozygous Familial Hypercholesterolemia Market Outlook
5.3.4.1. Market Size & Forecast
5.3.4.1.1. By Value
5.3.4.2. Market Share & Forecast
5.3.4.2.1. By Drug Class
5.3.4.2.2. By Route of Administration
5.3.4.2.3. By Technology
5.3.4.2.4. By Distribution Channel
5.3.5. South Korea Homozygous Familial Hypercholesterolemia Market Outlook
5.3.5.1. Market Size & Forecast
5.3.5.1.1. By Value
5.3.5.2. Market Share & Forecast
5.3.5.2.1. By Drug Class
5.3.5.2.2. By Route of Administration
5.3.5.2.3. By Technology
5.3.5.2.4. By Distribution Channel
6. Europe Homozygous Familial Hypercholesterolemia Market Outlook
6.1. Market Size & Forecast
6.1.1. By Value
6.2. Market Share & Forecast
6.2.1. By Drug Class
6.2.2. By Route of Administration
6.2.3. By Technology
6.2.4. By Distribution Channel
6.2.5. By Country
6.3. Europe: Country Analysis
6.3.1. France Homozygous Familial Hypercholesterolemia Market Outlook
6.3.1.1. Market Size & Forecast
6.3.1.1.1. By Value
6.3.1.2. Market Share & Forecast
6.3.1.2.1. By Drug Class
6.3.1.2.2. By Route of Administration
6.3.1.2.3. By Technology
6.3.1.2.4. By Distribution Channel
6.3.2. Germany Homozygous Familial Hypercholesterolemia Market Outlook
6.3.2.1. Market Size & Forecast
6.3.2.1.1. By Value
6.3.2.2. Market Share & Forecast
6.3.2.2.1. By Drug Class
6.3.2.2.2. By Route of Administration
6.3.2.2.3. By Technology
6.3.2.2.4. By Distribution Channel
6.3.3. Spain Homozygous Familial Hypercholesterolemia Market Outlook
6.3.3.1. Market Size & Forecast
6.3.3.1.1. By Value
6.3.3.2. Market Share & Forecast
6.3.3.2.1. By Drug Class
6.3.3.2.2. By Route of Administration
6.3.3.2.3. By Technology
6.3.3.2.4. By Distribution Channel
6.3.4. Italy Homozygous Familial Hypercholesterolemia Market Outlook
6.3.4.1. Market Size & Forecast
6.3.4.1.1. By Value
6.3.4.2. Market Share & Forecast
6.3.4.2.1. By Drug Class
6.3.4.2.2. By Route of Administration
6.3.4.2.3. By Technology
6.3.4.2.4. By Distribution Channel
6.3.5. United Kingdom Homozygous Familial Hypercholesterolemia Market Outlook
6.3.5.1. Market Size & Forecast
6.3.5.1.1. By Value
6.3.5.2. Market Share & Forecast
6.3.5.2.1. By Drug Class
6.3.5.2.2. By Route of Administration
6.3.5.2.3. By Technology
6.3.5.2.4. By Distribution Channel
7. North America Homozygous Familial Hypercholesterolemia Market Outlook
7.1. Market Size & Forecast
7.1.1. By Value
7.2. Market Share & Forecast
7.2.1. By Route of Administration
7.2.2. Drug Class
7.2.3. By Distribution Channel
7.2.4. By Technology
7.2.5. By Country
7.3. North America: Country Analysis
7.3.1. United States Homozygous Familial Hypercholesterolemia Market Outlook
7.3.1.1. Market Size & Forecast
7.3.1.1.1. By Value
7.3.1.2. Market Share & Forecast
7.3.1.2.1. By Drug Class
7.3.1.2.2. By Route of Administration
7.3.1.2.3. By Technology
7.3.1.2.4. By Distribution Channel
7.3.2. Mexico Homozygous Familial Hypercholesterolemia Market Outlook
7.3.2.1. Market Size & Forecast
7.3.2.1.1. By Value
7.3.2.2. Market Share & Forecast
7.3.2.2.1. By Drug Class
7.3.2.2.2. By Route of Administration
7.3.2.2.3. By Technology
7.3.2.2.4. By Distribution Channel
7.3.3. Canada Homozygous Familial Hypercholesterolemia Market Outlook
7.3.3.1. Market Size & Forecast
7.3.3.1.1. By Value
7.3.3.2. Market Share & Forecast
7.3.3.2.1. By Drug Class
7.3.3.2.2. By Route of Administration
7.3.3.2.3. By Technology
7.3.3.2.4. By Distribution Channel
8. South America Homozygous Familial Hypercholesterolemia Market Outlook
8.1. Market Size & Forecast
8.1.1. By Value
8.2. Market Share & Forecast
8.2.1. By Drug Class
8.2.2. By Route of Administration
8.2.3. By Distribution Channel
8.2.4. By Country
8.3. South America: Country Analysis
8.3.1. Brazil Homozygous Familial Hypercholesterolemia Market Outlook
8.3.1.1. Market Size & Forecast
8.3.1.1.1. By Value
8.3.1.2. Market Share & Forecast
8.3.1.2.1. By Drug Class
8.3.1.2.2. By Route of Administration
8.3.1.2.3. By Technology
8.3.1.2.4. By Distribution Channel
8.3.2. Argentina Homozygous Familial Hypercholesterolemia Market Outlook
8.3.2.1. Market Size & Forecast
8.3.2.1.1. By Value
8.3.2.2. Market Share & Forecast
8.3.2.2.1. By Drug Class
8.3.2.2.2. By Route of Administration
8.3.2.2.3. By Technology
8.3.2.2.4. By Distribution Channel
8.3.3. Colombia Homozygous Familial Hypercholesterolemia Market Outlook
8.3.3.1. Market Size & Forecast
8.3.3.1.1. By Value
8.3.3.2. Market Share & Forecast
8.3.3.2.1. By Drug Class
8.3.3.2.2. By Route of Administration
8.3.3.2.3. By Technology
8.3.3.2.4. By Distribution Channel
9. Middle East and Africa Homozygous Familial Hypercholesterolemia Market Outlook
9.1. Market Size & Forecast
9.1.1. By Value
9.2. Market Share & Forecast
9.2.1. By Drug Class
9.2.2. By Drug Type
9.2.3. By Technology
9.2.4. By Distribution Channel
9.2.5. By Country
9.3. MEA: Country Analysis
9.3.1. South Africa Homozygous Familial Hypercholesterolemia Market Outlook
9.3.1.1. Market Size & Forecast
9.3.1.1.1. By Value
9.3.1.2. Market Share & Forecast
9.3.1.2.1. By Drug Class
9.3.1.2.2. By Route of Administration
9.3.1.2.3. By Technology
9.3.1.2.4. By Distribution Channel
9.3.2. Saudi Arabia Homozygous Familial Hypercholesterolemia Market Outlook
9.3.2.1. Market Size & Forecast
9.3.2.1.1. By Value
9.3.2.2. Market Share & Forecast
9.3.2.2.1. By Drug Class
9.3.2.2.2. By Drug Type
9.3.2.2.3. By Technology
9.3.2.2.4. By Distribution Channel
9.3.3. UAE Homozygous Familial Hypercholesterolemia Market Outlook
9.3.3.1. Market Size & Forecast
9.3.3.1.1. By Value
9.3.3.2. Market Share & Forecast
9.3.3.2.1. By Drug Class
9.3.3.2.2. By Route of Administration
9.3.3.2.3. By Technology
9.3.3.2.4. By Distribution Channel
10. Market Dynamics
10.1. Drivers
10.2. Challenges
11. Market Trends & Developments
11.1. Recent Developments
11.2. Product Launches
11.3. Mergers & Acquisitions
12. Global Homozygous Familial Hypercholesterolemia Market: SWOT Analysis
13. Porter’s Five Forces Analysis
13.1. Competition in the Industry
13.2. Potential of New Entrants
13.3. Power of Suppliers
13.4. Power of Customers
13.5. Threat of Substitute Product
14. Competitive Landscape
14.1. AstraZeneca PLC
14.1.1. Business Overview
14.1.2. Company Snapshot
14.1.3. Products & Services
14.1.4. Current Capacity Analysis
14.1.5. Financials (In case of listed)
14.1.6. Recent Developments
14.1.7. SWOT Analysis
14.2. Viatris Inc.
14.3. Teva Pharmaceutical Industries Ltd.
14.4. Accord Healthcare
14.5. Changzhou Pharmaceutical Factory
14.6. Regeneron Pharmaceuticals, Inc.
14.7. Amryt Pharma plc
14.8. Amgen Inc.
14.9. Organon Global Inc.
14.10. CMP Pharma
15. Strategic Recommendations16. About the Publisher & Disclaimer

Companies Mentioned

  • AstraZeneca PLC
  • Viatris Inc.
  • Teva Pharmaceutical Industries Ltd.
  • Accord Healthcare
  • Changzhou Pharmaceutical Factory
  • Regeneron Pharmaceuticals, Inc.
  • Amryt Pharma plc
  • Amgen Inc.
  • Organon Global Inc.
  • CMP Pharma

Table Information

Report AttributeDetails
No. of Pages184
PublishedApril 2025
Forecast Period2024 - 2030
Estimated Market Value ( USD ) in 2024 $ 82.67 Million
Forecasted Market Value ( USD ) by 2030 $ 103.97 Million
Compound Annual Growth Rate3.8%
Regions CoveredGlobal
No. of Companies Mentioned10

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