OrthoBiologics provides state-of-the-art knowledge of current biologic therapies for a variety of orthopaedic conditions in a single source. The content is presented in a straightforward manner, including defining all currently available orthobiologic options, discussing processing characteristics and appropriate clinical use, and finally, summarizing clinical applications and outcomes as well as future potential directions.
In addition to covering current approaches and applications, the editors aim for this book to present “best practices” for those practicing and researching orthopaedic pathologies and orthobiologic treatments, including blood and cellular based therapies. The editors are world-renown experts in the field and this book fills a gap in the market.
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Table of Contents
1. Autologous blood; platelet-rich plasma and platelet-poor plasma2. Defining, measuring and optimizing platelet-rich plasma
3. Optimal use of platelet-rich plasma and plateletpoor plasma
4. Where orthobiologics started: what are mesenchymal stem cells?
5. Bone marrow-derived mesenchymal stromal cells
6. Defining, optimizing, and measuring bone marrow aspirate and bone marrow concentrate
7. Optimal clinical use of bone marrow aspirate and bone marrow aspirate concentrate
8. Adipose mesenchymal stromal cells
9. Defining, optimizing, measuring, and utilizing adipose, MFAT, etc.
10. Optimal clinical use of adipose mesenchymalstromal cells
11. Basic science and preclinical evidence for amniotic membrane2derived allografts in
12. Defining, optimizing, and measuring amniotic/ placental mesenchymal stem cells
13. Optimal clinical use of amniotic/placental mesenchymal stem cells
14. Synovial mesenchymal stem cells
15. Peripheral blood stem cells
16. Orthobiologics-growth factors and mediators
17. Orthobiologics in the procedure room-who, what, where, when, and how
18. Orthobiologics in the operating room-who, what, where, when, and how
19. The changing regulatory environment: regulations and restrictions
20. Bioscaffolds for osteochondral injuries of the knee
21. Orthobiologics on the horizon
22. Complications associated with orthobiologics
Authors
Rachel M. Frank Associate Professor in Orthopaedic Surgery, University of Colorado School of Medicine, USA; Director, Joint Preservation Program, Department of Orthopaedic Surgery, University of Colorado School of Medicine, USA; Associate Fellowship Director, Sports Medicine, Department of Orthopaedic Surgery, University of Colorado School of Medicine, USA.Dr. Rachel M. Frank is a board-certified Orthopedic Surgeon and Sports Medicine Specialist, focusing on the surgical and nonsurgical management of knee, shoulder, and elbow injuries. She has specialized training and technical expertise in advanced knee and shoulder arthroscopy, joint preservation surgery, cartilage/meniscus restoration surgery, shoulder instability surgery, care of the female athlete, and orthobiologics. She is an Associate Professor of Orthopedic Surgery at the University of Colorado School of Medicine and is the Director of the Joint Preservation Program at the same university. Dr. Frank serves as the Editor-In-Chief for the Journal of Cartilage and Joint Preservation (JCJP), has authored over 300 peer-reviewed journal articles, over 70 book chapters, and 5 edited books. She presents her research both nationally and internationally at orthopedic conferences and meetings every year. She is head Team Orthopaedic Surgeon for the Colorado Rapids professional soccer team, and a network Team Physician for U.S. Soccer.
Jorge Chahla Assistant Professor of Orthopedic Surgery and Director of Biomechanical Research and of the International Fellowship Program, Rush University Medical Center, USA.Dr. Jorge Chahla is an Orthopedic Surgeon who specializes in the treatment of complex knee, hip, and other sports-related injuries. He is an Associate Professor in the Department of Orthopedic Surgery at Rush University Medical Center and serves as the Director of Biomechanical Research and of the International Fellowship Program. He is a Team Physician for the Chicago White Sox (MLB), the Chicago Bulls (NBA), and the Chicago Fire (MLS). Dr. Chahla completed several fellowships at the top programs in the United States. He is internationally recognized for his contributions to the field of sports medicine injuries through minimally invasive techniques as well as for being a pioneer in novel biological treatments. Dr. Chahla has a strong focus on joint preservation procedures and cartilage restoration techniques with more than 500 publications in prestigious scientific journals, over 50 book chapters, 8 edited books, and he presents his research both nationally and internationally at orthopedic conferences and meetings every year.
Garrett Jackson Orthopaedic Surgery Clinical Research Fellow, Midwest Orthopaedics, Rush University Medical Center, Chicago, IL, USA.Dr. Garrett R. Jackson is an Orthopedic Surgery Resident at the University of Missouri School of Medicine. Before residency, he served as a Research Fellow at Rush University Medical Center with a focus on sports medicine injuries, joint preservation, and meniscus/cartilage restoration. Dr. Jackson has authored over 100 peer-reviewed journal articles in prestigious scientific journals and contributed to numerous book chapters. He has presented his research at both international and national orthopedic conferences, demonstrating his commitment to advancing orthopedic research and practice.
