Localized Surface Plasmon Resonance Biosystems: Fundamentals, Design and Applications presents fundamental theory and an overview of the application of advanced methods and concepts for the development of nanophotonic biosystems. It introduces LSPR biosensing concepts followed by a discussion of the material design aspects of the LSPR technology, including a description of methods used for developing new plasmonic materials and biosystems. After presenting the fundaments of LSPR biosystems, the book deals with practical aspects of implementing this technology in biosensor systems, discussing a variety of topics such as large-scale plasmonic structures, on-chip photonics which avoid use of light sources, and much more. Other sections cover tuning photonic properties for developing new applications related to biosensing and opportunities and challenges of such biosystems for translational research. This is an important resource for both scientists and engineers interested on the complete cycle of device development, from conceptualization to development and deployment, in the field of nanoplasmonic biosensing.
Table of Contents
1. Principles of Localized surface plasmon resonance (LSPR) biosensors2. Methods for LSPR Material Design
3. LSPR Chips
4. Integration of Microfluidics with LSPR Chips
5. Simulation tools for LSPR systems
6. Interfacing LSPR chips with Bioentities
7. Optical Measurement Systems for LSPR Chips
8. Electrical Measurement Systems for LSPR Chips
9. Portable Instrumentation Design for LSPR systems
10. Point-of-care LSPR Systems for Medical Diagnostics
11. Portable LSPR for Environment, Agriculture and Food
12. Technology Transfer and Scaling up of LSPR Biosystems
13. Future of LSPR Biosystems
Authors
Nikhil Bhalla Assistant Professor in Electronic Engineering, Ulster University, UK. Dr Nikhil Bhalla is an Assistant Professor in Electronic Engineering at Ulster University, UK. He works in the field of biosensors with a strong focus in plasmonics and nanomaterials: he holds a first degree in electronics from BITS-Pilani, India, Masters from National Tsing Hua University, Taiwan, in electronics & nanotechnology and a PhD from the University of Bath, UK, in electronic engineering. After PhD, he joined the postdoctoral training program at University of Bath and Okinawa Institute of Science and Technology (OIST), in Japan.In the past 5 years, he has published several articles in leading journals in the field of plasmonics and has received funds for his research as a PI/CI from JSPS, Okinawa Prefectural Government, Japan, Engineering and Physical Sciences Research Council, UK, Royal Society, UK, and Department of Economy, Northern Ireland. Sivashankar Krishnamoorthy Group Leader of Materials Research and Technology, Luxembourg Institute of Science and Technology, Belvaux, Luxembourg. Dr. Sivashankar Krishnamoorthy has over 17 years of experience in advancing nanotechnologies. His research interests include polymeric and colloidal self-assemblies, micro/nanofabrication, surface engineering and functional integration of nanostructures within optical and electronic devices including light emitting diodes, flash memories, plasmonic sensors, in-vitro cell expansion, and lab on chip devices. As the Group Leader of Materials Research and Technology at Luxembourg Institute of Science and Technology, his responsibilities include scientific, technical, strategic, and managerial leadership of a multidisciplinary and multicultural research team.
Dr. Krishnamoorthy has active ongoing contributions and collaborations along lines of fabrication and investigation of plasmon-enhanced spectroscopic biosensors engineered for enhanced analyte leverage over electromagnetic hotspots. In parallel, his work also drives fundamental contributions in engineering surface structure and functionality at a molecular level towards enhanced analyte mass transport and analyte capture on affinity biosensors.
