Transplant Oncology: A Frontier in Multidisciplinary Cancer Care summarizes new and evolving scientific findings and discoveries in the field of cancer and transplants and gives guidance on future directions and related research. With a strong focus on transplant oncology, the book examines new and evolving topics, including the utilization of immunotherapy in special patient populations as well as the clinical updates on new concepts in the field such as using circulating tumor DNA (ctDNA) as a tool for minimal disease detection, surveillance, and treatment response evaluation as well as rejection assessment and detection in transplant patient for oncological indications. Sections cover applications of transplant medicine and surgery in oncology to improve patient survival outcome and quality of life. The book gives insight into anticancer strategies, such as initiating studies in genomics and cancer immunogenomics based on new insights in liver cancer. In addition, it describes how the adoption of surgical transplantation techniques in oncology has improved conventional resection and bridged the gap between tumor and transplant immunology. This is a must have reference for all those that want to be familiar and up-to-date with the dynamic changes in the field including practicing physicians, scientists, and trainees.
Table of Contents
Section I: Transplant Oncology: An Evolving Field in Cancer Care 1. Transplant Oncology: concept, history, and evolution 2. Prehistory of Transplant Oncology Era Section II: Transplantations for Oncological Indications 3. Hepatocellular Carcinoma 4. Cholangiocarcinoma and liver transplantation 5. Transplantation for Oncological Indications: Colorectal Cancer Liver Metastases 6. Liver transplantation for neuroendocrine neoplasms liver metastases 7. Hepatoblastoma Section III: Transplant Oncology and Immunotherapy 8. Transplant Oncology and Immunotherapy: Immunotherapy and liver transplants 9. b. Immunotherapy and kidney transplant 10. Immunotherapy and Hematopoietic Stem Cell Transplantation 11. Immunotherapy in the Era of Transplant Oncology: Risks and Complications 12. Immunotherapy and immunosuppressants: Considerations in the clinical practice Section IV: Transplant Oncology and Precision Medicine 13. Molecular profiling and Next-Generation Sequencing applications in transplant oncology 14. Circulating tumor DNA (ctDNA) as a new and evolving tool in solid organ transplantation 15. Cell-free DNA (cfDNA) biomarkers for solid organ transplant rejection 16. Artificial intelligence in transplant Oncology Section V: Solid Organ Transplant and Cancers Considerations 17. De Novo malignancy Post Liver Transplantation: Recent Insights on Epidemiology and Surveillance Strategies 18. History of cancer and transplant clearance: Considerations prior to transplantation Section VI: Surgical Aspects of Transplant Oncology 19. Robotic Surgery for Liver Cancer and Applications in Liver Transplantation 20. Resection versus Transplantation for Intrahepatic and Hilar Cholangiocarcinoma 21. Liver transplantations for secondary cancers: surgical considerations 22. New strategies for two-stage hepatectomy 23. Living Donor Liver Transplantation 24. Patient characteristics and evaluations prior to liver transplantation 25. Challenges of liver transplantation for transplant oncology indications 26. Future of transplant oncology of the liver
Authors
Maen Abdelrahim Houston Methodist, Section, Chief Gastrointestinal Medical Oncology, Medical Director Cockrell Center for Advanced Therapeutics (CCAT), Houston, TX, USA. Dr. Abdelrahim is a gastrointestinal medical oncologist and transplant oncologist with unique experience in malignancies treated by liver transplantation. He is the section chief of GI medical oncology at Houston Methodist Neal Cancer Center.He is heavily involved in the transplant oncology field and have been one of the pioneers in the field. He has published more than 230 original research articles, review articles, and book chapters in prestigious journals and publishing groups. He is a member of the American Society of Clinical Oncology, Society for Immunotherapy of Cancer, Cholangiocarcinoma Foundation, European Society for Medical Oncology, and International Liver Transplant Society
