- Describes the range of clinical manifestations of individual neuromuscular diseases; the power and limitations of electrodiagnostic techniques as they relate to neuromuscular disorders; the place of genetic studies in the diagnosis and prognostication of these diseases; and the scope and utility of newer imaging procedures in detecting and localizing the underlying pathologic process.
- Reviews neuromuscular physiology and the pathology of major diseases.
- Provides a readable, well-illustrated synthesis of clinical and investigative techniques in diagnosing neuromuscular diseases, with concise guidance on how to conduct clinical, electrodiagnostic, and ultrasound evaluations and the findings in various disease states.
- Covers a wide variety of electrodiagnostic and ultrasound procedures, including techniques for evaluating different individual nerves.
- Features video clips of waveforms and of ultrasound images to illustrate key concepts.
- An ideal resource for neuromuscular specialists, clinical neurologists, physiatrists, rehabilitation specialists, clinical neurophysiologists, and electromyographers, as well as trainees and those preparing for board certification in neurology, PM&R, neuromuscular medicine, clinical neurophysiology, and electrodiagnostic medicine.
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Any additional digital ancillary content may publish up to 6 weeks following the publication date.
Table of Contents
New chapters are shown in bold type. The other chapters will be extensively revised and updated.
INTRODUCTION
1. Approach to Neuromuscular Diagnosis
(The aim of this new chapter is to share the thought process that experienced neuromuscular clinician use in making diagnoses.)
2. Electrodiagnostic Methods for the Study of Nerve and Muscle
BASIC ASPECTS
3. Nerve Physiology
4. Neuromuscular Junction Physiology
5. Muscle Physiology and the Motor Unit
6. Electrodiagnostic Apparatus
7. General Aspects of Needle Electromyography
8. Clinical Aspects of Needle Electromyography
9. Nerve Conduction Studies: Basic Principles and Pathologic Correlations
10. Quantitative and Related Techniques of Electromyography
11. Other Electrodiagnostic Techniques for the Evaluation of Neuromuscular Disorders
12. Electrophysiologic Evaluation of the Autonomic Nervous System
13. Magnetic Resonance Imaging of Nerve and Muscle in Health and Disease
(A brief review of MR technology will be presented. The MR characteristics of healthy muscle and nerve will then be shared. Then, the imaging correlates to various diseases of muscle and nerve will be discussed.)
14. Neuromuscular Ultrasound
(The technology and apparatus will first be introduced. The technique of conducting an evaluation will be presented. The imaging characteristics of normal muscle and nerve will be discussed before moving to a discussion of the correlates to common disease of muscle and nerve.)
CLINICAL ASPECTS
15. Myopathic Disorders and Myalgia
16. Motor Neuron Disorders
17. Muscle Fiber and Motor Unit Hyperactivity States
18. Polyneuropathy and Mononeuropathy Multiplex
19. Root and Plexus Lesions
20. Neuromuscular Junction Disorders
NERVES IN THE UPPER EXTREMITIES
21. Median Neuropathies
22. Ulnar Neuropathies
23. Radial Neuropathies
24. Disturbances of Other Nerves in the Upper Extremities
NERVES IN THE LOWER EXTREMITIES
25. Peroneal Neuropathies
26. Tibial and Sural Neuropathies
27. Sciatic Neuropathies
28. Disturbances of Other Nerves in the Lower Extremities
CRANIAL NERVES
29. Facial Neuropathies
30. Disturbances of Other Cranial Nerves and the Phrenic Nerve
CENTRAL NERVOUS SYSTEM
31. Electrophysiologic Evaluation of Selected Aspects of the Central Nervous System
Appendix:
A Glossary of Terms Used in Clinical Electromyography
Video Clips
Authors
Michael J. Aminoff Distinguished Professor Emeritus in Neurology; University of California San Francisco. Dr. Michael J. Aminoff, Distinguished Professor Emeritus in neurology at the University of California San Francisco, is an internationally recognized neurologist, clinical investigator, and author. His published contributions led to the award of a Doctor of Science degree by the University of London in 2000. He is one of the two editors-in-chief of the four-volume Encyclopedia of the Neurological Sciences (2003; 2014) as well as one of the series editors of the multivolume Handbook of Clinical Neurology. He was editor-in-chief of the journal Muscle & Nerve from 1998 to 2007 and has served on numerous other editorial boards. He was a director of the American Board of Psychiatry and Neurology for eight years and served as board chair in 2011. In 2006, he received the Lifetime Achievement Award from the American Association of Neuromuscular & Electrodiagnostic Medicine and, in 2007, the A.B. Baker Award for Lifetime Achievement in Neurological Education from the American Academy of Neurology. In 2019 he received the Robert S. Schwab Award for outstanding contributions to research in peripheral clinical neurophysiology from the American Clinical Neurophysiology Society. Jeffrey W. Ralph Clinical Professor; Director, Neuromuscular Medicine Fellowship Program; University of California San Francisco.Dr. Jeffrey W. Ralph directs the neuromuscular medicine fellowship program at the University of California San Francisco (UCSF). He completed a neurology residency as well as fellowship training in neuromuscular medicine and clinical neurophysiology at UCSF. Dr. Ralph is an expert in the electrodiagnosis of neuromuscular diseases and in the clinical management of these diseases, especially peripheral neuropathies, and since 2004 has directed the Neuropathy Center at UCSF Medical Center. His research has addressed treatments for neuropathy caused by HIV/AIDS and muscle channelopathies.
Francis Walker Emeritus Professor of Neurology; Wake Forest University School of Medicine. Dr. Francis O. Walker joined the faculty of Wake Forest University School of Medicine in 1984 and is currently Emeritus Professor of Neurology. He has published widely on clinical neuropharmacology, neurophysiology, and neuromuscular imaging and has helped in the training of numerous fellows and residents. He has served on several editorial boards, helped create self-assessment and certifying examinations in clinical neurophysiology, and held leadership positions in medical societies including a term as president of the American Association of Neuromuscular and Electrodiagnostic Medicine. Dr. Walker has been a pioneer in the development of ultrasound as a means of evaluating the neuromuscular system, and he is a co-editor of the book Neuromuscular Ultrasound.
