New approach for drug repurposing represents drug discovery and development which is a tedious process that requires 10-15 years of time, investments up to $1-2 billion, and have high risk of failure to enter into market for clinical applications. As the drugs has to pass through number of developmental phase, the likelihood for a drug to be approved from phase I clinical trial to United States of Food and Drug Administration (USFDA) approval is less than 10%. More than 90% of drugs failed in due to toxicity, efficacy and clinical trials. Drug repurposing is one of the roadway to accelerating drug discovery and development for treating disease and thus to providing better quality of life.
This volume covers an overview of drug repurposing, novel methods, mechanism of action, lab on chip for drug repurposing, computational biology, system biology, artificial intelligence and machine learning for drug repurposing, target identification, target mining, high throughput drug screening, clinical trial of repurposed drug, repurposed biologics, and regulatory consideration and intellectual property right of repurposed drug. This volume highlights a number of aspects of the drug repurposing that can help the basic understanding of students, researchers, clinicians, entrepreneurs, and stakeholders to perform their research with great interest.
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Table of Contents
PrefaceVijai Singh
1. An introduction to drug repurposing
Vijai Singh
2. New approaches for drug repurposing
Govinda Raj and Deepak Balaji Thimiri Govindaraj
3. Reimagining old drugs with new Tricks:Mechanism, strategies and notable success in drug repurposing for neurological disorders
Pravir Kumar, Samuel Raj, Rashmi K. Ambasta, Neetu Rani, Aastha Kaushik, Shefali Kardam and Sonika Kag
4. Lab-on-chip for testing of repurposed drug
Alok Pandya
5. Computational biology approaches for drug repurposing
Mustafeez Mujtaba Babar
6. Synergizing Drug Repurposing and Target Identification for Neurodegenerative Diseases
Pravir Kumar, Mehar Sahu, Shrutikeri Vashishtha, Neha Kukreti, Ashima Gulia, Aashish Russell and Rashmi K. Ambasta
7. Artificial Intelligence and ML for drug repurposing
Anil G. Jegga and Sudhir Ghandikota
8. Genomic approaches for drug repurposing
Vijai Singh
9. Systems biology approaches for drug repurposing
Ajay Kumar I
10. High-throughput screening for drug repurposing
Sunday N. Okafor, Eze Chinecherem and Ahuchaogu Ikenna
11. Approaches of pre-clinical and clinical trials of repurposed drug
Ajay Kumar I
12. Repurposing of biologics and biopharmaceuticals
Ajay Kumar I
13. Innovative Target Mining Stratagems to Navigate Drug Repurposing Endeavours
Saraswathy Ganesan Rajalekshmi
14. Regulatory considerations and intellectual property right of repurposed drug
Mustafeez Mujtaba Babar
