The global lipid nanoparticle manufacturing market is estimated to grow from USD 0.37 billion in the current year to USD 2.53 billion by 2035, at a CAGR of 18.86% during the forecast period, till 2035.
The market sizing and opportunity analysis has been segmented across the following parameters:
Type of Lipid Nanoparticle
- Solid Lipid Nanoparticles
- Nanostructured Lipid Carriers
Type of Molecule Delivered
- Nucleic Acids
- Small Molecules
- Peptides/ Proteins
- Others
Company Size
- Very Large and Large
- Mid-sized
- Small
Therapeutic Area
- Infectious Diseases
- Oncological Disorders
- Blood Disorders
- Rare Diseases
- Other Disorders
Type of End-user
- Pharmaceutical and Biotechnology Companies
- Academic and Research Institutes
- Other End-users
Key Geographical Regions
- North America
- Europe
- Asia-Pacific
- Rest of the World
Lipid Nanoparticle Manufacturing Market: Growth and Trends
Over the past few decades, the pharmaceutical industry has witnessed significant growth. This is evident from the continuously growing pipeline of drug candidates that have been marketed or are being evaluated across several development stages. However, low drug solubility / permeability is one of the primary concerns associated with certain pharmacological products. Therefore, players engaged in the pharmaceutical domain are actively trying to identify ways to improve / augment physiochemical properties and drug-like behavior of pharmacological products. Amidst other alternatives, the use of lipid nanoparticles (LNPs) has garnered the attention of many drug developers. This can be attributed to the great versatility of LNPs, in terms of structure and functionality, as well as the ability to enhance the solubility and bioavailability of poorly water-soluble drugs.
Considering the routine operations-related and technical challenges, an increased number of pharmaceutical companies have demonstrated the preference to outsource their respective LNP production operations to specialized service providers. There are numerous benefits of engaging contract manufacturing firms for LNP manufacturing, such as access to new technologies (available with the service provider), larger capacities and greater operational flexibility. As a result, many of the companies are actively trying to consolidate their presence in this field, by entering into strategic alliances to broaden their respective service portfolios and LNP manufacturing capabilities. Given the benefits of using LNPs to improve drug-like properties, the demand for high quality LNPs nanoparticles is likely to drive considerable growth within the specialty contract manufacturing market in the coming years.
Lipid Nanoparticle Manufacturing Market: Key Insights
The report delves into the current state of the lipid nanoparticle manufacturing market and identifies potential growth opportunities within the industry. Some key findings from the report include:
- Over 40 companies claim to offer contract manufacturing services for lipid nanoparticles; majority of these firms are mid-sized players, based in North America.
- Several service providers have the necessary capabilities to offer lipid nanoparticle contract manufacturing, across different scales of operation and for encapsulating various types of molecules.
- Presently, close to 35 lipid nanoparticle technologies are being offered by companies worldwide in order to manufacture LNP based therapeutics; the market is characterized by the presence of small companies.
- Stakeholders have adopted various business models to maximize the gain from LNP technologies; majority of these technologies are intended for drug delivery via injectable route, primarily targeting oncological disorders.
- Currently, close to 60 players across the world, claim to provide contract manufacturing services to support the development and production of other types of lipids for various therapeutic purposes.
- In order to cater to the rising demand for lipid nanoparticles, service providers are continuously expanding their existing capabilities to drive compliance to evolving industry benchmarks.
- In pursuit of obtaining a competitive edge, industry stakeholders are actively advancing and innovating new LNP manufacturing technologies to enhance their respective portfolios.
- In order to expand their lipid nanoparticle service portfolios and gain access to emerging technologies, companies are actively entering into various strategic partnerships with various international and local players.
- Various mRNA-based therapeutic / vaccine developers across the world are anticipated to forge strategic alliances with LNP contract manufacturing service providers, to further augment their drug portfolio.
- The global installed lipid nanoparticle manufacturing capacity is spread across various geographies; majority of this capacity is installed in the production plants located in the US.
- Driven by the increasing number of chronic indications (requiring novel personalized therapies), and ongoing research on lipid nanoparticle-based therapeutics, this market is anticipated to grow at a CAGR of 12%, till 2035.
- The projected future opportunity for the lipid nanoparticle manufacturing market is likely to be well distributed across different target therapeutic areas, end-users and key geographical regions.
Lipid Nanoparticle Manufacturing Market: Key Segments
Currently, Solid Lipid Nanoparticles Occupy the Largest Share of the Lipid Nanoparticle Manufacturing Market
Based on the type of lipid nanoparticle, the market is segmented into solid lipid nanoparticles and nanostructured lipid carriers. At present, the solid lipid nanoparticles segment holds the maximum share of the lipid nanoparticle manufacturing market. This trend is likely to remain the same in the forthcoming years. It is worth highlighting that the lipid nanoparticle manufacturing market for nanostructured lipid carriers is likely to grow at a relatively higher CAGR.
Small Molecules are the Fastest Growing Segment of the Lipid Nanoparticle Manufacturing Market
Based on the type of molecule delivered, the market is segmented into nucleic acids, small molecules, proteins/peptides and others. Currently, nucleic acid holds the maximum share of the lipid nanoparticle manufacturing market. However, the small molecules segment is likely to dominate the lipid nanoparticle manufacturing market in the forthcoming decade.
Large and Very Large Companies are Likely to Dominate the Lipid Nanoparticle Manufacturing Market
Based on the company size, the market is segmented into very large and large companies, mid-sized companies and small companies. At present, very large and large companies hold the maximum share of the lipid nanoparticle manufacturing market. This trend is likely to remain the same in the forthcoming years. It is worth highlighting that the lipid nanoparticle manufacturing market for mid-sized companies is likely to grow at a relatively higher CAGR.
Oncological Disorders is the Fastest Growing Segment of the Lipid Nanoparticle Manufacturing Market
Based on the target therapeutic area, the market is segmented into infectious diseases, oncological disorders, blood disorders, rare diseases and other disorders. It is worth highlighting that currently, the oncological disorders segment holds a larger share of the lipid nanoparticle manufacturing market. This trend is likely to remain the same in the coming decade.
Currently, Pharmaceutical and Biotechnology Companies Occupy the Largest Share of the Lipid Nanoparticle Manufacturing Market
Based on the type of end-user, the market is segmented into pharmaceutical and biotechnology companies, academic and research institutes, and other end-users. It is worth highlighting that the majority of the current lipid nanoparticle manufacturing market is captured by pharmaceutical and biotechnology companies. This trend is likely to remain the same in the near future.
North America Accounts for the Largest Share of the Market
Based on key geographical regions, the market is segmented into North America, Europe, Asia-Pacific and Rest of the world. It is worth highlighting that, over the years, the market in Europe is expected to grow at a higher CAGR.
Key Players in the Lipid Nanoparticle Manufacturing Market include:
- Acuitas Therapeutics
- Ascendia Pharmaceuticals
- Avanti Polar Lipids
- BIOVECTRA
- CordenPharma
- Creative Biolabs
- Curapath
- Curia
- Emergent Biosolutions
- EUROAPI
- Evonik
- Formumax Scientific
- Fresinius Kabi
- Fujifilm
- Integrated Nanotherapeutics
- leon-nanodrugs
- Matinas BioPharma
- Merck
- Pantherna Therapeutics
- Precision NanoSystems
- TLC Biosciences
Primary Research Overview
The opinions and insights presented in this study were influenced by discussions conducted with multiple stakeholders. The research report features detailed transcripts of interviews held with the following industry stakeholders:
- Founder and Chief Executive Officer, LIPOSOMA
- Former Director, Process Development - Chemistry and Former Acting Manager, Biotech Process Development, BIOVECTRA
- Formulation Scientist, OZ Biosciences
Lipid Nanoparticle Manufacturing Market: Research Coverage
- Market Sizing and Opportunity Analysis: The report features an in-depth analysis of the lipid nanoparticle manufacturing market, focusing on key market segments, including [A] type of lipid nanoparticle, [B] type of molecule delivered, [C] company size, [D] target therapeutic area, [E] type of end-user and [F] key geographical regions.
- Market Landscape (Lipid Nanoparticles Manufacturers): A comprehensive evaluation of lipid nanoparticles manufacturers, considering various parameters, such as [A] year of establishment, [B] company size, [C] location of headquarters, [D] location of manufacturing facility, [E] scale of operation, [F] type of molecule delivered, [F] therapeutic area and [G] type of additional services offered.
- Market Landscape (Lipid Nanoparticles Technology Developers): A comprehensive evaluation of lipid nanoparticle technology developers, considering various parameters, such as [A] type of formulation method, [B] type of molecule delivered, [C] compatible dosage form, [D] route of administration, [E] therapeutic area. Additionally, the chapter includes information on the lipid nanoparticle technology developers, including [F] year of establishment, [G] company size (in terms of employee count), [H] location of headquarters, [I] business model and [J] most active players (in terms of number of technologies developed).
- Market Landscape (Lipid Contract Manufacturers): A comprehensive evaluation of lipid contract manufacturers, considering various parameters, such as [A] year of establishment, [B] company size (in terms of employee count), [C] location of headquarters, [D] location of manufacturing facilities, [E] scale of operation, [F] type of lipid manufactured, [G] type of product and [H] type of additional services offered.
- Company Competitiveness Analysis (Lipid Nanoparticle Contract Manufacturers): A comprehensive competitive analysis of lipid nanoparticle contract manufacturing organizations, examining factors, such as [A] company strength, [B] service strength and [C] number of LNP manufacturing facilities.
- Technology Competitiveness Analysis: A comprehensive competitive analysis of lipid nanoparticle technologies, examining factors, such as [A] developer strength, [B] technology strength and [C] technology applicability.
- Company Profiles: In-depth profiles of key industry players offering LNP manufacturing services and LNP technology, focusing on [A] company overviews, [B] LNP service / technology portfolio, [C] recent developments and [D] an informed future outlook.
- Partnerships and Collaborations: An analysis of partnerships established in this sector, since 2019, covering [A] year of partnership, [B] type of partnership, [C] type of molecule, [D] therapeutic area, [E] type of partner, [F] most active players (in terms of the number of partnerships signed) and [G] regional distribution of partnership activity.
- Likely Partner Analysis: A detailed evaluation of mRNA vaccines and therapeutics developers that are most likely to collaborate with lipid nanoparticle manufacturers. This analysis considers various relevant parameters, including [A] developer strength (which takes into account a company’s size and experience in this field), [B] pipeline strength (which takes into account the number of mRNA drugs in the pipeline), as well as [C] other mRNA drug related capabilities (which takes into account the target therapeutic area, route of administration and type of candidate).
- Make versus Buy Decision Framework: A comprehensive make-or-buy framework that highlights the crucial factors influencing companies (referred to as sponsors in later sections) in their decision to either outsource LNP manufacturing operations or establish in-house capabilities.
- Capacity Analysis: Estimation of global installed lipid nanoparticle contract manufacturing capacity, derived from data provided by various stakeholders in the public domain. This analysis emphasizes the distribution of the available capacity on the basis of [A] company size (small, mid-sized, and large and very large companies), [B] scale of operation (preclinical, clinical and commercial) and [C] geography (North America, Europe and Asia-Pacific).
- Market Impact Analysis: The report analyzes various factors such as drivers, restraints, opportunities, and challenges affecting the market growth.
Key Questions Answered in this Report
- How many companies are currently engaged in this market?
- Which are the leading companies in this market?
- What is the global installed capacity of lipid nanoparticle contract manufacturers?
- What factors are likely to influence the evolution of this market?
- What is the current and future market size?
- What is the CAGR of this market?
- How is the current and future market opportunity likely to be distributed across key market segments?
Reasons to Buy this Report
- The report provides a comprehensive market analysis, offering detailed revenue projections of the overall market and its specific sub-segments. This information is valuable to both established market leaders and emerging entrants.
- Stakeholders can leverage the report to gain a deeper understanding of the competitive dynamics within the market. By analyzing the competitive landscape, businesses can make informed decisions to optimize their market positioning and develop effective go-to-market strategies.
- The report offers stakeholders a comprehensive overview of the market, including key drivers, barriers, opportunities, and challenges. This information empowers stakeholders to stay abreast of market trends and make data-driven decisions to capitalize on growth prospects.
Additional Benefits
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Table of Contents
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- Acuitas Therapeutics
- Ascendia Pharmaceuticals
- Avanti Polar Lipids
- BIOVECTRA
- CordenPharma
- Creative Biolabs
- Curapath
- Curia
- Emergent Biosolutions
- EUROAPI
- Evonik
- Formumax Scientific
- Fresinius Kabi
- Fujifilm
- Integrated Nanotherapeutics
- leon-nanodrugs
- Matinas BioPharma
- Merck
- Pantherna Therapeutics
- Precision NanoSystems
- TLC Biosciences
Methodology
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