Nanotechnology has shown immense promise for advancing blood glucose control. This technology offers the potential to safeguard pancreatic cells from autoimmune destruction by driving the creation of innovative therapeutic agents that can be delivered to specific targets.
In this book, you will find a comprehensive exploration of diabetes and its approved medical treatments. The book delves into how nanotechnology can amplify the efficacy of current treatment modalities, potentially paving the way for a gene therapy solution to combat this disease. Starting with the history of diabetes treatment, the book explains treatment challenges for diabetes before getting into the three ways nanoscience is helping in diabetes treatment: insulin delivery, drug delivery and nucleotide delivery. Each chapter is contributed by accomplished experts in their respective fields, who strive to offer a thorough, yet accessible discussion of the subject.
In this book, you will find a comprehensive exploration of diabetes and its approved medical treatments. The book delves into how nanotechnology can amplify the efficacy of current treatment modalities, potentially paving the way for a gene therapy solution to combat this disease. Starting with the history of diabetes treatment, the book explains treatment challenges for diabetes before getting into the three ways nanoscience is helping in diabetes treatment: insulin delivery, drug delivery and nucleotide delivery. Each chapter is contributed by accomplished experts in their respective fields, who strive to offer a thorough, yet accessible discussion of the subject.
Readership
General readers, science enthusiasts and scholars interested in diabetes medicine.Table of Contents
- Contents
- Preface
- List of Abbreviations
- List of Contributors
- Ramin Malboosbaf and Neda Hatami
- Introduction
- Type 1 Diabetes
- Role of Genetics
- Role of the Environment
- Infection
- Dietary Factors
- Natural History and Prognosis
- Effects on Glucose Metabolism
- Effect on Lipid Metabolism
- Effects on Protein Metabolism
- Pathophysiology of Type 2 Diabetes
- Insulin-Sensitive Tissues
- Insulin Resistance and the Risk of Type 2 Diabetes Mellitus
- Adipose Tissue and Insulin Resistance
- Role of Gut Microbiome and Metabolome in Diabetes and Insulin Resistance
- Role of Gut Hormones
- Genetics
- Environmental Influences
- Sleeping
- Natural History and Prognosis
- Maturity-Onset Diabetes of the Young, Latent Autoimmune Diabetes of Adults, and Double
- Diabetes
- Conclusion
- References
- Ramin Malboosbaf and Neda Hatami
- Introduction
- Pharmacologic Therapy for Adults With Type 1 Diabetes
- Insulin Therapy
- Pharmacologic Therapy for Adults With Type 2 Diabetes
- Non-Insulin Treatment for Type 2 Diabetes Mellitus
- Insulin Secretagogues
- Sulfonylureas
- Meglitinides
- Amylin Analogs
- Biguanides
- Metformin
- Insulin Sensitizers
- Alpha-Glucosidase Inhibitors (Agis)
- Incretin Mimetics
- Glp-1 Agonists
- Dpp-4 Inhibitors
- Sodium-Glucose Co-Transporter Two Inhibitors
- Insulin in Type 2 Diabetes
- Conclusion
- References
- Morteza Rafiee-Tehrani, Somayeh Handali, Mohammad Vaziri, Sepideh Nezhadi And
- Farid Abedin Dorkoosh
- Introduction
- Nanocarriers Based Insulin Delivery
- Liposome
- Chitosan
- Plga
- Solid Lipid Nanoparticle (Sln)
- Hydroxyapatite (Hap)
- Nanogels
- Micelle
- Dendrimer
- Exosomes
- Conclusion
- References
- N. Vishal Gupta, M. Sharadha, K. Trideva Sastri, Souvik Chakraborty, Hitesh
- Kumar, Vikas Jain and Surajit Dey
- Nanomedicine in Diabetes: Need-Based Approach
- Nanomedicine in the Management of Diabetes
- Organic Material-Based Nanomedicines
- Lipid-Based Nanocarriers
- Liposomes and Pro-Liposomes
- Solid Lipid Nanoparticles (Slns)
- Nanostructured Lipid Carriers (Nlcs)
- Nano-Emulsions
- Microemulsions
- Nano-Capsules
- Self-Nano-And Micro-Emulsifying Drug Delivery Systems (Smedds and Snedds)
- Natural Polymeric Nanoparticles
- Chitosan-Based Nanoparticles
- Alginate-Based Nanoparticles
- Dextran-Based Nanoparticles
- Synthetic Polymeric Nanoparticles
- Plga (Poly Lactic-Co-Glycolic Acid) Based Nanoparticles
- Pla Based Nanoparticles
- Miscellaneous
- Nanosuspensions
- Dendrimers
- Micelles
- Hydrogels
- Inorganic Material-Based Nanomedicine
- Carbon Nanotubes (Cnts)
- Metallic Nanoparticles (Mnps)
- Specialized Nanomedicines
- Natural Carrier Systems-Based Nanomedicines
- Erythrocytes-Based Nanocarriers
- Exosomes-Based Nanocarriers
- Phytosome-Based Nanocarriers
- Sphingosomes-Based Nanocarriers
- Challenges With Nanomedicine in the Management of Diabetes
- Conclusion and Future Perspectives
- References
- Ali Rastegari
- Introduction
- Dna Delivery Approach
- Rna Delivery Approach
- Future and Challenges
- Conclusion
- References
- Subject Index
Author
- Ali Rastegari
