Linking Neuroscience and Behavior in COVID-19 examines the effect of both the virus and the pandemic on behavior and mental health. Chapters look at the burden of the COVID-19 pandemic on those with pre-existing conditions, including Parkinson's disease and multiple sclerosis. The ongoing consequences of the pandemic on the mental health of the broad populace are discussed. As well as the neurological effects of the virus itself, chapters discuss psychological concerns including depression and anxiety. Finally, the chapters also include aspects relevant to managing care and the treatment of conditions. A broad range of conditions preceding, caused by, or emerging for the first time during the pandemic are also detailed.
International and Life Course Aspects of COVID-19 describes the nuances and international variations of COVID-19 in different populations and age groups. This volume details those differences in chapters examining the effects of the virus at different life stages, including newborns, children, adolescents, and older populations. Consideration of the age-specific effects of COVID-19 on the brain are a major focus unique to this resource. International observations and global outcomes are also described. This volume is relevant for all clinicians working to ensure the best outcomes for patients with COVID-19 worldwide.
Management, Body Systems, and Case Studies in COVID-19 describes the assessment and treatment of patients infected with the novel coronavirus that causes the varied symptoms of COVID-19. Detailing this multisystem disease and the organs and tissues affected, this volume features chapters on several body systems. Conditions affecting the respiratory, hematological, hepatobiliary, renal, gastrointestinal, nervous, musculoskeletal, and cardiovascular systems are addressed. The fundamental role of telemedicine during the pandemic is also discussed. This volume is relevant for all clinicians and scientists working to ensure the best outcomes for patients with COVID-19.
Table of Contents
Features, Transmission, Detection, and Case Studies in COVID-19Preface
Section A: SARS-CoV-2 and COVID-19: Introductory chapters and setting the scene
1. Coronavirus disease 2019 (COVID-19) pandemic in context: Systemic effects
2. Early warning of SARS-CoV-2 infection
3. Mobile phones and their use to study dynamics of the COVID-19 pandemic
Section B: Structure, transmission and avoidance
4. Cis regulatory elements: A novel communication route between the host cell and the SARS-CoV-2 genome
5. SARS-CoV-2 ORF8: Structure, evolution, molecular function, and its contribution to the
pathogenicity of the virus
6. SARS-CoV-2 spike protein binding ligands and its application in COVID-19 therapeutics
7. SARS-CoV-2 bulldozes the autophagy pathway and unhinges mitochondrial quality control
thereby driving neurodegeneration-A hypothesis
8. The Omicron variant of SARS-CoV-2
9. Monitoring SARS-CoV-2 spread in hospitals
10. Computational analysis of mutations in SARS-CoV-2 variants spike protein and protein
interactions
11. Airborne transmission of SARS-CoV-2
12. Reducing transmission of SARS-CoV-2 with face masks: Its potential protective effects
13. Digital twin of ventilation system against COVID-19 transmission and infection risk
14. Pets and SARS-CoV-2: What is their role in the epidemiology of the disease?
15. SARS-CoV-2 transmission in dental practice
16. SARS-CoV-2 compared with influenza and respiratory syncytial virus in terms of vertical
transmission
17. Reducing droplets and aerosols in the surgical setting and applications to the COVID-19
pandemic
18. SARS-CoV motion dynamics: Linking in droplet size
19. Ventilation and airborne particles in classrooms: Implications for the COVID-19 pandemic
20. Indoor transmission of the SARS-CoV-2 virus through aerosols emitted by e-cigarettes
Section C: Impact and effects
21. The Impact of COVID-19 on first responders
22. COVID-19 and suspected drug-induced liver injury
23. Pulmonary fibrosis in COVID-19
24. The effect of SARS-CoV-2 infection on cancer: Clinical correlation and
potential pathological mechanism
25. Severe SARS-CoV-2, plateletendothelium interactions, and cardiovascular injury
26. Cardiometabolic syndrome and COVID-19: Pathophysiological aspects
27. COVID-19 and type 1 and 2 diabetes: An overview
28. COVID-19 and older adults: An overview
29. COVID-19 and male fertility
30. COVID-19 and obesity: An overview
Section D: Treatments, strategies, and vaccines
31. COVD-19 vaccines and their impact: An overview
32. Exploring the promise of COVID-19 vaccines: A review of preclinical studies
33. Drugs actively being investigated for use in COVID-19
34. The biology of neutralizing antibody therapy with REGEN-COV
35. The intensive care unit and percutaneous tracheostomy in patients with coronavirus disease
2019
36. Cardiac effects of drugs and vaccines used to treat and prevent COVID-19
37. COVID-19 pandemic and isolation: Impact on sleep
38. Strategies in the COVID-19 pandemic: Disinfection of gloved hands
39. In silico studies on established antivirals on SARS-CoV-2 RNAdependent RNA polymerase
40. The COVID-19 cytokine storm and its immunomodulatory treatment
41. Safety and efficacy of nebulization for reducing the intensity of viral load and clinical manifestations in patients with COVID-19
Section E: Detection and biomarkers
42. Bronchoalveolar lavage (BAL) and use in detection of SARS-CoV-2
43. SARS-CoV-2 testing and vaccination among people who use drugs
44. Homocysteine as a biomarker in COVID-19
45. Assessment of smell and taste in COVID-19
46. S-gene analysis: RT-PCR and Sanger sequencing applied to SARS-CoV-2 virus
47. False-negative results in screening for SARS-CoV-2
48. Sample pooling and SARS-CoV-2 assays
49. Biomarkers of invasive mechanical ventilation in obesity and metabolic syndrome in patients
with COVID-19
Section F: Case studies with mini review
50. Hypoxia and heart-lung interactions in COVID-19: The significance of right heart dysfunction and shunt
51. Ulnar nerve dysfunction as COVID-19 sequelae
52. Case study: Coronavirus disease 2019 and acute kidney injury
53. Case study: The detection and treatment of a pneumothorax in a patient with coronavirus disease 2019 pneumonia
54. Proposal and demonstration of a survey method for the prevention of airborne transmission: Case studies in healthcare and welfare facilities
Section G: Resources
55. Recommended resources for the features, transmission, and detection of coronavirus disease
2019 (COVID-19)
International and Life Course Aspects of COVID-19
Preface
Section A: Introductory chapters and setting the scene
1. COVID-19 and mortality in children
2. Congenital and perinatal COVID-19: Diagnostic challenges, current management, and
outcomes
3. COVID-19 vaccine strategies
4. Social and community responses to public health and social measures for COVID-19: Community engagement for risk preparedness
Section B: International aspects
5. The COVID-19 pandemic in Italy: Ecological background and epidemiological dynamics
6 COVID-19 pandemic in Nigeria
7. A bird's eye view of the COVID-19 pandemic in India: The past, present, and future
8. COVID-19 pandemic in Europe Malgorzata Gruchola and Malgorzata
9. COVID-19 in Latin America and the Caribbean (LAC)
10. COVID-19 in Sudan: A multiperspective review
11. Asymptomatic infection by SARSCoV-2 at the beginning of the epidemic in Cuba: Evidence from
case series
12. Stress and anxiety due to COVID-19 in India
13. COVID-19 pandemic in Korea: A focus on medical management
14. Stigma experienced by healthcare workers during the COVID-19 pandemic: Global and Egyptian
perspectives
Section C: Reproduction, pregnancy and new-borns
15. The COVID-19 pandemic and breastfeeding
16. Impact of SARS-CoV-2 infection on female fertility
17. Fetal death due to maternal COVID-19
18. The COVID-19 pandemic and identification of SARS-CoV-2 in the prostate
19. COVID-19 in pregnant women: Clinical course, treatment, and maternal/fetal outcome of vaccination during pregnancy
20. Impact of the COVID-19 pandemic: SARS-CoV-2-specific IgG antibodies and their vertical
transfer
21. COVID-19 vaccination during lactation
22. Being pregnant during the COVID-19 pandemic: Impact of the trimester of gestation and measures of maternal mental health
23. COVID-19 related maternal mortality and SARS-CoV-2 variants
24. COVID-19-associated complications in pregnant women and neonates
25. SARS-CoV-2 and its impact on the developing fetal neurologic system
26. Impact of maternal SARS-CoV-2 infection in the placenta
Section D: Children and adolescents
27. T cells and their subsets in children with COVID-19
28. Pediatric inflammatory multisystem syndrome and SARS-CoV-2
29. Impact of COVID-19 pandemic on nutritional status of children
30. COVID-19 in children: Nutrition care
31. Eating disorders in children during the COVID-19 pandemic
32. Body composition in children with SARS-CoV-2 infection: Short and long term consequences
33. Risk of SARS-CoV-2 infection and childhood obesity
34. The impact of the COVID-19 pandemic during the lockdown and the post-COVID-19 effects on
the family system of children with disabilities
35. The impact of the COVID-19 pandemic on ordinary vaccination programs for very young children: BCG, MMR, poliomyelitis, and beyond
36. Immune responses to SARS-CoV-2 infection and vaccination in children
37. The impact of the COVID-19 pandemic: How physical fitness changes in children
38. The COVID-19 pandemic and children: Impact on physical activity
39. The COVID-19 pandemic and stress related to schooling
40. Suicidal thoughts and behaviors among adolescents during the COVID-19 pandemic
41. The COVID-19 pandemic: Attending to hand hygiene measures in young people
(a review of different studies)
42. Child and adolescent COVID-19 vaccination: Trends, hesitancy, and strategies for increasing vaccination
43. Social distancing behavior and mental health in US adolescents during the COVID-19 pandemic
44. Thrombotic complications in children and adolescents with SARS-CoV-2 infection
45. Features of SARS-CoV-2 infection and vaccination in children: A focus on magnetic resonance imaging of the heart
46. SARS-CoV-2 infection and the cytokine levels and pathway in children: An updated narrative
Section E: Older adults
47. Risk factors related to COVID-19 among older adults
48. Reducing loneliness and social isolation among the elderly during the COVID-19 pandemic
49. Features and measures of depression in the elderly and the impact of the COVID-19
pandemic: Linking in preexisting mental health
50. Experiences of disabled older adults in adult day care centers during the COVID-19 pandemic
51. Using single-cell analysis to investigate disease severity in elderly patients with COVID-19
52. COVID-19 and older adult food practices: A social determinants of health perspective
53. Older subjects and immunogenicity of mRNA COVID-19 vaccines
54. Noninvasive respiratory support in octogenarian patients with COVID-19
Section F: Case studies with mini review
55. Case study: COVID-19 severity in diabetic patients with and without seizure
56. Case study: Nonpharmaceutical interventions for COVID-19 and their social impact in Japan
57. Case study: Factors affecting vaccine uptake-Australian perspectives
58. The impact of the COVID-19 pandemic on an older disabled person
59. COVID-19 in the newborn: Clinical course and effects of maternal vaccination in pregnancy
Section G: Resources
60. Recommended resources for the international and life course aspects of coronavirus disease 2019 (COVID-19)
Linking Neuroscience and Behavior in COVID-19
Preface
Section A: Introductory chapters and setting the scene
1. The historical aspects of the SARS-CoV-2 virus and the ensuing pandemic
2. Different variants of SARS-CoV-2
3. Lateral flow assay for SARS-CoV-2 infection: Uses and limitations
4. Linking community participation, mobility disabilities, and the COVID-19 pandemic
5. Influence of the sources used to obtain information on COVID-19 and their impact on mental health
Section B: Impact on behavior and psychology
6. The psychological experiences and distress of defined populations in the COVID-19 pandemic: Doctors
7. Impact of COVID-19 on behavior in autism spectrum disorder
8. Prepandemic stressors in mental health responses to the COVID-19 pandemic: Early life adversities and beyond
9. Compulsive hoarding in the COVID-19 pandemic
10. The psychological experiences and distress in Japan and Sweden during the COVID-19 pandemic
11. The COVID-19 pandemic, mental health, and sleep: Linking depression, anxiety, and perceived
stress
12. The COVID-19 pandemic and the occupational overload of health professionals: Indicators of
burnout
13. Neurocognitive sequelae of SARS-CoV-2 infection: Pathogenesis, risk factors, assessment, and implications
14. Acute neurocognitive disorder as a presenting manifestation of COVID-19
15. Mental health and the impact of confinement
16. Cannabis use in the COVID-19 pandemic: Changes in different populations and implications
for policy
17. Impact of COVID-19 on mental health in women: Socioeconomic groups and global aspects
18. Quality of life assessment of patients after COVID-19
19. COVID-19 pandemic and remote working: Toward a new way of working
20. Long COVID and its persistence: A focus on mental health
21. The impact of the COVID-19 pandemic on behavioral and psychological features of vulnerable groups: Patients with multiple sclerosis and their quality of life
Section C: Effects on neurological structures and mechanisms
23. Linking pediatric COVID-19 with basal ganglia and dentate nucleus
24. Sensory disorders, neuroinflammation, and COVID-19
25. The effects of COVID-19 isolations on nonmotor features of Parkinson's disease
26. Myelitis following COVID-19: The road so far
27. The corpus callosum: Effects due to SARS-CoV-2 infection and the mRNA vaccine
28. Assessing the impact of prenatal SARS-CoV-2 exposure on infants' neurodevelopment: A comprehensive analysis of current evidence
29. Electroencephalographic features with COVID-19
30. Survivors of COVID-19 and clinical neuropsychological domain characteristics
31. Neuroinflammation following SARS-CoV-2 infection
32. Functional magnetic resonance imaging and depressive symptoms in subjects with COVID-19
33. Impact of COVID-19 on the brain: Antibodies against brain stem antigens
34. The kynurenine pathway and role in mental health of post-COVID-19 patients
Section D: Management, support and treatments
35. Management of brain tumors in the COVID-19 pandemic
36. The impact of the COVID-19 pandemic on ischemic stroke management: From hyperacute to chronic phase
37. Long COVID and the potential use of palmitoylethanolamide
38. Cognitive assessments in post-COVID syndrome: A focus on the neuropsychological tests and
protocols
39. Supporting individuals with intellectual and developmental disabilities during the COVID-19
pandemic
40. Preserving well-being and quality of life through school-based interventions focused on physical
activity during the COVID-19 pandemic
41. Hesitancy in using COVID-19 prevention behaviors among African Americans: Strategies to
build confidence
42. New strategies for psychological well-being at work
43. Mitigating mental health changes with virtual reality technology during COVID-19: A narrative
44. Music therapy for patients with neurological disorders during COVID-19 pandemic
45. Mental health and the modulating effects of receiving the COVID-19 vaccination
46. Personalized cognitive behavioral therapy on patients with obesity in COVID-19 pandemic
47. Social anxiety disorder and COVID-19: Treatment with cognitive behavioral therapy
48. Burnout during the COVID-19 pandemic: Modulating role of mindfulness
Section E: Case studies with mini review
49. Case study: Evaluation of a long Covid assessment service (LCAS)
50. Case study: Navigating youth mental health and addictions care in the context of the COVID-19 pandemic
51. Case study: Restless leg syndrome associated with COVID-19
Section F: Resources
52. Recommended resources for linking neuroscience and behavior in coronavirus disease
(COVID-19)
Management, Body Systems, and Case Studies in COVID-19
Preface
Section A: Introductory chapters and setting the scene
1. Hand hygiene strategies
2. Approved vaccines for the COVID-19 pandemic: Linking in future perspectives
3. Molecular methods for SARS-CoV-2 variant detection
Section B: Management
4. Systematic patient assessment for acute respiratory tract ailments (SPARTA): A simple tool to improve outcomes from COVID-19
5. Point of care ultrasound for coronavirus disease 2019: The multiorgan approach to COVID-19
6. COVID-19 in patients with inflammatory bowel diseases: Features and guidelines
7. Management of COVID-19 and clinical nutrition
8. The management of head and neck cancer in COVID-19
9. The COVID-19 pandemic: Inventory management and allocation of personal protective
equipment
10. Clinical management in the COVID-19 pandemic: Rheumatic disease
11. Managing migraines during the COVID-19 pandemic: An Italian experience
12. Managing acute ischemic stroke in the SARS-CoV-2 pandemic
13. Impact of the coronavirus disease 2019 pandemic on patients with hypertension
14. Neurosurgical trauma management during COVID-19 restrictions
15. The COVID-19 pandemic and management of weight gain: Implications for obesity
16. COVID-19 and the management of heart failure using telemedicine
Section C: Guidelines for different treatment clinics
17. Guidelines for breast imaging in the COVID-19 pandemic
18. Vaccine-induced (immune) thrombotic thrombocytopenia (VITT): Diagnosis, guidelines,
and reporting
19. Lung cancer in the era of COVID-19
20. Multisystem inflammatory syndrome in children/pediatric inflammatory multisystem
syndrome: Clinical guidelines
Section D: Impact on the respiratory system
21. Ground-glass nodules in the lungs of COVID-19 patients
22. Cardiothoracic imaging in patients affected by COVID-19
23. Cystic fibrosis and bronchial epithelial cells in SARS-CoV-2 infection
24. Biomechanics and mechanobiology of the lung parenchyma following SARS-CoV-2 infection
25. Long noncoding RNA profiling in respiratory specimens from COVID-19 patients
26. COVID-19 and acute pulmonary embolism
27. The usefulness of the alveolar-arteriolar gradient during the COVID-19 pandemic
Section E: Effects on cardiovascular and hematological systems
28. Cardiac manifestations of COVID-19: An overview
29. Limb ischemia and COVID-19
30. Thrombosis and coagulopathy in COVID-19: A new narrative
31. COVID-19 myocarditis: Features of echocardiography
32. COVID-19 lockdown and impact on arrhythmias
33. Cardiometabolic disease and COVID-19: A new narrative
34. Postrecovery COVID-19 and interlinking diabetes and cardiovascular events
35. COVID-19 patients and extracorporeal membrane oxygenation
36. Sars-CoV-2 infection in different hematological patients
Section F: Effects on body systems
37. Dermatological reactions associated with personal protective equipment use during
the COVID-19 pandemic
38. Hemodialysis patients, effects of infections by SARS-CoV-2 and vaccine response
39. Coinfections with COVID-19: A focus on tuberculosis (TB)
40. Patients with autoimmune liver disease and the impact of Sars-COV-2 infection
41. COVID-19 severity and nonalcoholic fatty liver disease
42. Changes in obesity and diabetes severity during the COVID-19 pandemic at Virginia
Commonwealth University health system
43. The diabetic patient and concomitant conditions rhinoorbital-cerebral mucormycosis
and COVID-19
44. Tissue location of SARS-CoV-2 RNA: A focus on bone and implications for skeletal health
45. Linking between gastrointestinal tract effects of COVID-19 and tryptophan metabolism
46. Organ damage in SARS-CoV-2 infection in children: A focus on acute kidney injury
47. Obesity, COVID-19 severity, and mortality
48. Upper and lower gastrointestinal symptoms and manifestations of COVID-19
49. The COVID-19 survivors: Impact on skeletal muscle strength
Section G: Case studies with mini review
50. A case report: COVID-19 meningoencephalitis and intracranial hemorrhage
51. Case study: Oral mucosal lesions in patients with COVID-19
52. Case study: COVID-19 pneumonia presented with cavitary lesions
53. Case study: Optic neuritis in SARS-CoV-2 infection
Section H: Resources
54. Recommended resources relevant to the body systems involvement
and management of COVID-19
Authors
Rajkumar Rajendram Consultant in Internal Medicine, King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy's, King's and St. Thomas Medical School, King's College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.
Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.
Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.
Dr Rajendram's focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King's College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.
Victor R Preedy Professor, Department of Clinical Biochemistry, King's College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King's College London, UK Visiting Professor, University of Hull, UK. Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King's College Hospital and Emeritus Professor of Nutritional Biochemistry at King's College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King's College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books. Vinood Patel Professor, University Westminster, UK. Vinood B. Patel, BSc, PhD, FRSC, is currently Professor in Clinical Biochemistry at the University of Westminster. In 2014 Dr Patel was elected as a Fellow to The Royal Society of Chemistry. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King's College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School, NC, USA studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of liver disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding mitochondrial oxidative stress in neurological disorders and iron dysregulation in diabetes. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to the use or investigation of active agents or components. These books include The Handbook of Nutrition, Diet, and Epigenetics, Branched Chain Amino Acids in Clinical Nutrition, Cancer: Oxidative Stress and Dietary Antioxidants, Toxicology: Oxidative Stress and Dietary Antioxidants, Molecular Nutrition: Vitamins, The Neuroscience of Pain, Cognitive Behavioural Therapy. He is Editor of the ten-volume series Biomarkers in Disease: Methods, Discoveries and Applications Colin R Martin Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK. Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.