This report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market’s historic and forecast market growth by geography.
The cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market size has grown exponentially in recent years. It will grow from $12.35 billion in 2024 to $14.95 billion in 2025 at a compound annual growth rate (CAGR) of 21.1%. The growth in the historic period can be attributed to increasing cancer incidence, clinical success stories, growing aging population, increased awareness, and early diagnosis.
The cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market size is expected to see rapid growth in the next few years. It will grow to $30.06 billion in 2029 at a compound annual growth rate (CAGR) of 19.1%. The growth in the forecast period can be attributed to expanding indications, emerging pipeline molecules, market competition and pricing dynamics, personalized medicine approaches, global healthcare infrastructure improvements. Major trends in the forecast period include advancements in biomarker identification, rise of oral CDK 4/6 inhibitors, emergence of CDK 4/6 inhibitors in other cancer types, focus on overcoming resistance mechanisms, clinical trials exploring novel CDK 4/6 inhibitors.
The anticipated increase in the prevalence of breast cancer is poised to drive the growth of the cyclin-dependent kinase (CDK) 4/6 inhibitor drug market. Breast cancer, originating in breast cells, prompts the demand for targeted therapies such as CDK4/6 inhibitors, addressing specific types of breast cancer and contributing to managing the escalating prevalence of the disease. As reported by the American Cancer Society in January 2023, breast cancer cases surged from 284,200 in 2021 to 300,590 in 2023, marking a significant increase of 5.76%. Consequently, the rising prevalence of breast cancer is forecasted to be a pivotal driver propelling growth within the cyclin-dependent kinase (CDK) 4/6 inhibitor drug market.
The augmented investment in research and development endeavors for breast cancer treatment is expected to significantly boost the cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market. The increased funding in breast cancer treatment facilitates the innovation and expansion of CDK4/6 inhibitor drugs, enhancing their efficacy and broadening their applications, thereby fostering market expansion. For instance, Susan G. Komen, a reputable US-based breast cancer organization, allocated $21.7 million in June 2022 to sponsor 48 novel research initiatives at 26 esteemed academic medical institutions across the United States. These initiatives aim to enhance patient outcomes, particularly for individuals grappling with aggressive forms of breast cancer or facing recurrence or metastasis. Hence, the amplified investment in research and development for breast cancer treatment emerges as a key factor driving the growth of the cyclin-dependent kinase (CDK) 4/6 inhibitor drug market.
Major companies in the cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market are concentrating on developing technologically advanced solutions, including AI-based tools to reduce toxicities in treatment and address various critical industry needs. These AI tools for hormonal breast cancer treatment aim to personalize therapies, minimize toxicities, predict adverse effects, and support timely interventions, ultimately enhancing the safety and effectiveness of treatments. For example, in May 2024, SOLTI, an innovative breast cancer research company based in Spain, launched an AI-based tool designed to reduce toxicities in the treatment of patients with hormonal breast cancer. This groundbreaking tool analyzes both cancerous and non-cancerous elements in breast tissue samples, allowing for more accurate predictions of treatment outcomes and helping to identify patients who may not need aggressive chemotherapy. By mitigating unnecessary side effects and enabling personalized treatment plans, the AI tool seeks to improve patient quality of life and enhance overall treatment efficacy. This advancement follows promising results from SOLTI's PATRICIA study, which emphasized the advantages of combining hormone therapy with targeted treatments for advanced ER+/HER2+ breast cancer.
In July 2022, Pfizer Inc., a renowned US-based pharmaceutical company specializing in CDK4/6 inhibitor drugs, embarked on a collaboration with Arvinas Inc., a prominent biopharmaceutical company also based in the United States. Their joint objective involves the development and commercialization of ARV-471, an investigative oral PROTAC (PROteolysis TArgeting Chimera) estrogen receptor protein degrader. This partnership is geared towards addressing the treatment needs of patients coping with locally advanced or metastatic breast cancer. Pfizer Inc. intends to synergize its expertise in CDK4/6 inhibitor drugs to maximize the therapeutic potential and effectiveness of ARV-471 in treating this challenging medical condition.
Major companies operating in the cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market report are Pfizer Inc., Merck & Co. Inc., Novartis AG, Bristol Myers Squibb Company, AstraZeneca PLC, Eli Lilly and Company, Boehringer Ingelheim International GmbH, Gilead Sciences Inc., Incyte Corporation, Jiangsu Hengrui Pharmaceuticals Co. Ltd., Dr. Reddy’s Laboratories Ltd., Piramal Group, Hanmi Pharm Co. Ltd., Incepta Pharmaceuticals Ltd., Beacon Pharmaceuticals PLC, Bluepharma, Astex Pharmaceuticals, Arvinas Inc, G1 Therapeutics Inc., Carisma Therapeutics Inc., Beta Pharma Inc., Syros Pharmaceuticals Inc., Cyclacel Pharmaceuticals Inc., Onconova Therapeutics Inc., Context Therapeutics Inc., NanoDaru.
North America was the largest region in the cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market in 2024. The regions covered in the cyclin-dependent kinase (cdk) 4/6 inhibitor drugs market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the cyclin-dependent kinase (cdk) 4/6 inhibitor drugs market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The cyclin-dependent kinase (CDK) 4/6 inhibitor drug market consists of sales of trilaciclib and ramiven drugs. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
Cyclin-dependent kinase (CDK) 4/6 inhibitor drugs are a class of targeted therapy medications employed in the treatment of specific types of hormone receptor-positive, HER2-negative breast cancer. These drugs focus on inhibiting enzymes known as CDK4 and CDK6, disrupting signals that stimulate the proliferation of malignant cells.
The primary CDK 4/6 inhibitor drugs include palbociclib (Ibrance), ribociclib (Kisqali), and abemaciclib (Verzenio). Palbociclib, for instance, is a targeted therapy medication designed for treating hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-) breast cancer. It is often utilized in combination with endocrine therapy, offering an effective treatment option for patients with advanced or metastatic breast cancer. These drugs cater to various patient groups, such as premenopausal, postmenopausal, and others. The end users encompass hospitals, clinics, research laboratories, and retail pharmacies.
The cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market research report is one of a series of new reports that provides cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market statistics, including cyclin-dependent kinase (CDK) 4/6 inhibitor drugs industry global market size, regional shares, competitors with a cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market share, detailed cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market segments, market trends and opportunities, and any further data you may need to thrive in the cyclin-dependent kinase (CDK) 4/6 inhibitor drugs industry. This cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future- scenario of the industry.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
This product will be delivered within 3-5 business days.
The cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market size has grown exponentially in recent years. It will grow from $12.35 billion in 2024 to $14.95 billion in 2025 at a compound annual growth rate (CAGR) of 21.1%. The growth in the historic period can be attributed to increasing cancer incidence, clinical success stories, growing aging population, increased awareness, and early diagnosis.
The cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market size is expected to see rapid growth in the next few years. It will grow to $30.06 billion in 2029 at a compound annual growth rate (CAGR) of 19.1%. The growth in the forecast period can be attributed to expanding indications, emerging pipeline molecules, market competition and pricing dynamics, personalized medicine approaches, global healthcare infrastructure improvements. Major trends in the forecast period include advancements in biomarker identification, rise of oral CDK 4/6 inhibitors, emergence of CDK 4/6 inhibitors in other cancer types, focus on overcoming resistance mechanisms, clinical trials exploring novel CDK 4/6 inhibitors.
The anticipated increase in the prevalence of breast cancer is poised to drive the growth of the cyclin-dependent kinase (CDK) 4/6 inhibitor drug market. Breast cancer, originating in breast cells, prompts the demand for targeted therapies such as CDK4/6 inhibitors, addressing specific types of breast cancer and contributing to managing the escalating prevalence of the disease. As reported by the American Cancer Society in January 2023, breast cancer cases surged from 284,200 in 2021 to 300,590 in 2023, marking a significant increase of 5.76%. Consequently, the rising prevalence of breast cancer is forecasted to be a pivotal driver propelling growth within the cyclin-dependent kinase (CDK) 4/6 inhibitor drug market.
The augmented investment in research and development endeavors for breast cancer treatment is expected to significantly boost the cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market. The increased funding in breast cancer treatment facilitates the innovation and expansion of CDK4/6 inhibitor drugs, enhancing their efficacy and broadening their applications, thereby fostering market expansion. For instance, Susan G. Komen, a reputable US-based breast cancer organization, allocated $21.7 million in June 2022 to sponsor 48 novel research initiatives at 26 esteemed academic medical institutions across the United States. These initiatives aim to enhance patient outcomes, particularly for individuals grappling with aggressive forms of breast cancer or facing recurrence or metastasis. Hence, the amplified investment in research and development for breast cancer treatment emerges as a key factor driving the growth of the cyclin-dependent kinase (CDK) 4/6 inhibitor drug market.
Major companies in the cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market are concentrating on developing technologically advanced solutions, including AI-based tools to reduce toxicities in treatment and address various critical industry needs. These AI tools for hormonal breast cancer treatment aim to personalize therapies, minimize toxicities, predict adverse effects, and support timely interventions, ultimately enhancing the safety and effectiveness of treatments. For example, in May 2024, SOLTI, an innovative breast cancer research company based in Spain, launched an AI-based tool designed to reduce toxicities in the treatment of patients with hormonal breast cancer. This groundbreaking tool analyzes both cancerous and non-cancerous elements in breast tissue samples, allowing for more accurate predictions of treatment outcomes and helping to identify patients who may not need aggressive chemotherapy. By mitigating unnecessary side effects and enabling personalized treatment plans, the AI tool seeks to improve patient quality of life and enhance overall treatment efficacy. This advancement follows promising results from SOLTI's PATRICIA study, which emphasized the advantages of combining hormone therapy with targeted treatments for advanced ER+/HER2+ breast cancer.
In July 2022, Pfizer Inc., a renowned US-based pharmaceutical company specializing in CDK4/6 inhibitor drugs, embarked on a collaboration with Arvinas Inc., a prominent biopharmaceutical company also based in the United States. Their joint objective involves the development and commercialization of ARV-471, an investigative oral PROTAC (PROteolysis TArgeting Chimera) estrogen receptor protein degrader. This partnership is geared towards addressing the treatment needs of patients coping with locally advanced or metastatic breast cancer. Pfizer Inc. intends to synergize its expertise in CDK4/6 inhibitor drugs to maximize the therapeutic potential and effectiveness of ARV-471 in treating this challenging medical condition.
Major companies operating in the cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market report are Pfizer Inc., Merck & Co. Inc., Novartis AG, Bristol Myers Squibb Company, AstraZeneca PLC, Eli Lilly and Company, Boehringer Ingelheim International GmbH, Gilead Sciences Inc., Incyte Corporation, Jiangsu Hengrui Pharmaceuticals Co. Ltd., Dr. Reddy’s Laboratories Ltd., Piramal Group, Hanmi Pharm Co. Ltd., Incepta Pharmaceuticals Ltd., Beacon Pharmaceuticals PLC, Bluepharma, Astex Pharmaceuticals, Arvinas Inc, G1 Therapeutics Inc., Carisma Therapeutics Inc., Beta Pharma Inc., Syros Pharmaceuticals Inc., Cyclacel Pharmaceuticals Inc., Onconova Therapeutics Inc., Context Therapeutics Inc., NanoDaru.
North America was the largest region in the cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market in 2024. The regions covered in the cyclin-dependent kinase (cdk) 4/6 inhibitor drugs market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the cyclin-dependent kinase (cdk) 4/6 inhibitor drugs market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The cyclin-dependent kinase (CDK) 4/6 inhibitor drug market consists of sales of trilaciclib and ramiven drugs. Values in this market are ‘factory gate’ values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
Cyclin-dependent kinase (CDK) 4/6 inhibitor drugs are a class of targeted therapy medications employed in the treatment of specific types of hormone receptor-positive, HER2-negative breast cancer. These drugs focus on inhibiting enzymes known as CDK4 and CDK6, disrupting signals that stimulate the proliferation of malignant cells.
The primary CDK 4/6 inhibitor drugs include palbociclib (Ibrance), ribociclib (Kisqali), and abemaciclib (Verzenio). Palbociclib, for instance, is a targeted therapy medication designed for treating hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-) breast cancer. It is often utilized in combination with endocrine therapy, offering an effective treatment option for patients with advanced or metastatic breast cancer. These drugs cater to various patient groups, such as premenopausal, postmenopausal, and others. The end users encompass hospitals, clinics, research laboratories, and retail pharmacies.
The cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market research report is one of a series of new reports that provides cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market statistics, including cyclin-dependent kinase (CDK) 4/6 inhibitor drugs industry global market size, regional shares, competitors with a cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market share, detailed cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market segments, market trends and opportunities, and any further data you may need to thrive in the cyclin-dependent kinase (CDK) 4/6 inhibitor drugs industry. This cyclin-dependent kinase (CDK) 4/6 inhibitor drugs market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future- scenario of the industry.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
This product will be delivered within 3-5 business days.
Table of Contents
1. Executive Summary2. Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market Characteristics3. Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market Trends and Strategies4. Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market - Macro Economic Scenario Including the Impact of Interest Rates, Inflation, Geopolitics, Covid and Recovery on the Market32. Global Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market Competitive Benchmarking and Dashboard33. Key Mergers and Acquisitions in the Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market34. Recent Developments in the Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
5. Global Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Growth Analysis and Strategic Analysis Framework
6. Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market Segmentation
7. Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market Regional and Country Analysis
8. Asia-Pacific Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
9. China Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
10. India Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
11. Japan Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
12. Australia Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
13. Indonesia Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
14. South Korea Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
15. Western Europe Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
16. UK Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
17. Germany Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
18. France Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
19. Italy Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
20. Spain Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
21. Eastern Europe Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
22. Russia Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
23. North America Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
24. USA Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
25. Canada Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
26. South America Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
27. Brazil Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
28. Middle East Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
29. Africa Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market
30. Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market Competitive Landscape and Company Profiles
31. Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market Other Major and Innovative Companies
35. Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Market High Potential Countries, Segments and Strategies
36. Appendix
Executive Summary
Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs Global Market Report 2025 provides strategists, marketers and senior management with the critical information they need to assess the market.This report focuses on cyclin-dependent kinase (cdk) 4/6 inhibitor drugs market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
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Description
Where is the largest and fastest growing market for cyclin-dependent kinase (cdk) 4/6 inhibitor drugs? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The cyclin-dependent kinase (cdk) 4/6 inhibitor drugs market global report answers all these questions and many more.The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market’s historic and forecast market growth by geography.
- The market characteristics section of the report defines and explains the market.
- The market size section gives the market size ($b) covering both the historic growth of the market, and forecasting its development.
- The forecasts are made after considering the major factors currently impacting the market. These include:
- The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.
- Market segmentations break down the market into sub markets.
- The regional and country breakdowns section gives an analysis of the market in each geography and the size of the market by geography and compares their historic and forecast growth. It covers the growth trajectory of COVID-19 for all regions, key developed countries and major emerging markets.
- The competitive landscape chapter gives a description of the competitive nature of the market, market shares, and a description of the leading companies. Key financial deals which have shaped the market in recent years are identified.
- The trends and strategies section analyses the shape of the market as it emerges from the crisis and suggests how companies can grow as the market recovers.
Scope
Markets Covered:
1) By Drug Type: Palbociclib (Ibrance); Ribociclib (Kisqali); Abermaciclib (Verzenio)3) By Patient: Pre-Menopausal; Post-Menopausal; Other Patients
3) By End-Users: Hospitals; Clinics; Research Laboratories; Retail Pharmacies
Key Companies Mentioned: Pfizer Inc.; Merck & Co. Inc.; Novartis AG; Bristol Myers Squibb Company; AstraZeneca PLC
Countries: Australia; Brazil; China; France; Germany; India; Indonesia; Japan; Russia; South Korea; UK; USA; Canada; Italy; Spain
Regions: Asia-Pacific; Western Europe; Eastern Europe; North America; South America; Middle East; Africa
Time Series: Five years historic and ten years forecast.
Data: Ratios of market size and growth to related markets, GDP proportions, expenditure per capita.
Data Segmentation: Country and regional historic and forecast data, market share of competitors, market segments.
Sourcing and Referencing: Data and analysis throughout the report is sourced using end notes.
Delivery Format: PDF, Word and Excel Data Dashboard.
Companies Mentioned
Some of the major companies featured in this Cyclin-Dependent Kinase (CDK) 4/6 Inhibitor Drugs market report include:- Pfizer Inc.
- Merck & Co. Inc.
- Novartis AG
- Bristol Myers Squibb Company
- AstraZeneca PLC
- Eli Lilly and Company
- Boehringer Ingelheim International GmbH
- Gilead Sciences Inc
- Incyte Corporation
- Jiangsu Hengrui Pharmaceuticals Co. Ltd.
- Dr. Reddy’s Laboratories Ltd
- Piramal Group
- Hanmi Pharm Co. Ltd.
- Incepta Pharmaceuticals Ltd
- Beacon Pharmaceuticals PLC
- Bluepharma
- Astex Pharmaceuticals
- Arvinas Inc
- G1 Therapeutics Inc.
- Carisma Therapeutics Inc.
- Beta Pharma Inc.
- Syros Pharmaceuticals Inc.
- Cyclacel Pharmaceuticals Inc.
- Onconova Therapeutics Inc.
- Context Therapeutics Inc.
- NanoDaru
Table Information
Report Attribute | Details |
---|---|
No. of Pages | 200 |
Published | March 2025 |
Forecast Period | 2025 - 2029 |
Estimated Market Value ( USD | $ 14.95 Billion |
Forecasted Market Value ( USD | $ 30.06 Billion |
Compound Annual Growth Rate | 19.1% |
Regions Covered | Global |
No. of Companies Mentioned | 26 |