This reference presents information about models utilized in experimental medicine and pharmaceutical research and development for several human diseases. Written by experts in immunology, cancer biology and pharmacology, the book provides readers with handy notes and updated data on animal models that are critical to research planning and lab execution.
The main feature of the book is a set of 12 structured chapters that focus on a specific disease such as cancer, infectious diseases, autism, autoimmune diseases, Alzheimer’s disease and anemia. The contributors have gathered information on a wide range of genetic and physiological animal models that are employed in research with comparative charts that highlight their main differences. The book also includes chapters for special topics like food allergies and dentistry. Additional features of the book are an explanation of disease mechanisms that give an easy understanding, notes for idiopathic models and specific clinical conditions, and a list of references for advanced readers.
Animal Models In Experimental Medicine is essential reading for scholars, graduate students and senior researchers in life sciences and clinical medicine. It also serves as a resource for professionals involved in bench-to-bedside pharmaceutical projects.
The main feature of the book is a set of 12 structured chapters that focus on a specific disease such as cancer, infectious diseases, autism, autoimmune diseases, Alzheimer’s disease and anemia. The contributors have gathered information on a wide range of genetic and physiological animal models that are employed in research with comparative charts that highlight their main differences. The book also includes chapters for special topics like food allergies and dentistry. Additional features of the book are an explanation of disease mechanisms that give an easy understanding, notes for idiopathic models and specific clinical conditions, and a list of references for advanced readers.
Animal Models In Experimental Medicine is essential reading for scholars, graduate students and senior researchers in life sciences and clinical medicine. It also serves as a resource for professionals involved in bench-to-bedside pharmaceutical projects.
Readership
Scholars, graduate students and senior researchers in life sciences and clinical medicine; professionals involved in bench-to-bedside pharmaceutical projects.Table of Contents
Chapter 1 Animal Models for Cancer- Fahad N. Alonazi, Yousef M. Hawsawi, Helal G. Alanazi, Adel M. Alqarni, Suad A.
- Alghamdi and Rakan J. Alanazi
- Introduction
- Mechanisms of Cancer Disease
- Cell Cycle
- Characteristics of Developing Tumors
- Escaping or Evading Growth Suppressors
- Ability to Enable Replicative Immortality
- Capacity to Sustain Proliferative Signalling
- Genome Instability and Mutations
- Capability for Resisting Apoptosis
- Tumour-Promoting Inflammation
- Triggering Invasion and Metastasis
- Capability for Inducing/Accessing the Vasculature
- Avoiding Immune Destruction System
- Cellular Metabolism Reprogramming
- Animal Models in Cancer Research
- Mice
- Chemically Induced Mice
- Genetically Engineered Mice
- Patient-Derived Tumor Xenograft
- Zebrafish
- Drosophila
- Non-Human Primates
- Conclusion
- References
- Mohammed A. Afifi, Mohammed W. Al-Rabia and Deema I. Fallatah
- Introduction
- Schistosomiasis Model
- Ascaris Lumbericoides Model
- Fasciola Hepatica Model
- Hepatitis C Virus Model
- Listeria Monocytogenes Model
- Entamoeba Histolytica Model
- Cytomegalovirus Animal Model
- Non-Primate Species
- Non-Human Primates
- Conclusion
- References
- Noufa Al Onazi, Mona Alanazi, Ghfren Aloraini and Aisha Al Anazi
- Type-1 Diabetes Mellitus, Non-Obese Diabetic (T1Dm) in Animal
- Models
- Introduction
- Epidemiology of Type-1 Diabetes Mellitus
- Risk Factors for Type-1 Diabetes Mellitus
- Animal Models of Type-1 Diabetes Mellitus
- Non-Obese Diabetic Mouse (Nod)
- Genetically Modified Mice Models
- Biobreeding (Bb) Rat
- Komeda Diabetes Prone (Kdp) Rat
- Conclusion
- Type 2 Diabetes Mellitus (T2Dm) in Animal Models
- Introduction
- Disease Models Listed by Animals in the Past
- Cabc in Large Animals
- Differences from Human Models
- Autoimmune Thyroid Diseases in Animal Models
- Introduction
- Epidemiology of Autoimmune Thyroid Diseases
- Risk Factors for Autoimmune Thyroid Diseases
- Possible Mechanism of Disease Development
- Animal Models of Human Aitd
- The Spontaneous Aitd Animal Model
- Induced Aitd Model
- Conclusion
- Arthritis in Animal Models
- Introduction
- The Animal Models Used
- Disease Mechanism
- Rat Adjuvant Arthritis
- The Cytokine Responses During the Course of Arthritis
- The Features of Each Model
- Differences from Human Models
- In Vivo Models for Ra
- Conclusion
- Refrences
- Yousef Hawsawi, Abdulaziz Al Anizi, Faihan Al Anizi and Fahad E. Albisi
- Introduction
- General Overview
- Animal Models of Anemia of Inflammation
- The Mouse Models of Anemia of Inflammation
- Transgenic Models Anemia of Inflammation
- The Rats’ Models of Anemia of Inflammation
- Fish Models of Anemia of Inflammation
- Animal Models of Iron Deficiency Anemia During Pregnancy
- Animal Models of Iron Overload Hemochromatosis (Hh)
- Animal Models of Menkes Syndrome
- Animal Models of Wilson Disease
- Conclusion
- References
- Ammar Y. Jastaniah
- Introduction
- Mice
- Pdapp
- Tg2576
- App23
- Tgcrnd8
- App/Ps1
- 3Xtg-Ad
- 5Xfad
- Appnl-G-F Knock-In Mice
- Apoe4-Tr
- Trem2 Ko/Appps1
- Ps19
- Aldh2 Ko
- Injury-Based and Trauma-Based Models
- Other Ko Mice
- Chemically Induced Ad Models
- Mouse Model Drawbacks
- Rats
- Familial Swedish and Indiana
- Psapp (Tg478/Tg1116/Tg11587)
- Ad Tau
- Chemically-Induced
- Large Animals
- Non-Human Primates
- Conclusion
- References
- Mohammed W. Al-Rabia and Mohammed A. Afifi
- Introduction
- Asthma Phenotypes/Endotypes
- Animal Models and Asthma: Value, Criteria of Selection, and Limitations
- Murine Models: Investigation of Asthma Pathogenesis and Airway Remodeling
- Murine Models: Investigation of the Genetic Basis of Asthma
- Murine Models: Role in Drug Discovery for Asthma
- Murine Models in Asthma: Limitations and Validity of Data Extrapolation
- Non-Murine Models for Asthma
- Conclusion
- References
- Rakan J. Alanazi
- Introduction
- Disease Mechanism
- Disease Models Listed by Animals
- Features of Each Model
- Rabbit Model
- Rat Model
- Pig and Non-Human Model
- Other Animal Models of Atherosclerosis
- Difference from Human Models
- Conclusion
- References
- Talal Adnan Basha
- Introduction
- Review of Food Hypersensitivity Pathogenesis
- Animal Models of Food Allergy
- Murine Model
- Mouse Model With Adjuvant
- Mouse Model Without Adjuvant
- Genetically Modified Mice
- Transgenic/Humanized Mouse Model
- Rat Food Allergy Model
- Guinea Pig Model
- Canine Model
- Swine Model
- Sheep Model
- Conclusion
- References
- Jana Ali Alnajim, Huda Abdullah Almutairi and Khalid Jamal Alanazi
- Introduction
- Disease Mechanism
- Periodontal Disease
- Dental Caries
- Oral Cancer
- Disease Model Listed by Animals
- Animal Models
- Features of Each Animal Models Used in Periodontology
- Dogs
- Cats
- Rats
- Hamsters
- Minks
- Miniature Pigs
- Mice
- Baker Mouse Model
- Non-Human Primates
- Other Animals
- Rabbit
- Horses
- Features of Each Model Used in Oral Cancer
- Rats Model
- Mouse Model
- Other Models
- Hamster Model
Author
- Faris Q. Alenzi
