Polymers for Oral Drug Delivery Technologies covers the fundamentals of oral drug delivery and various aspects of polymer technology in oral drug delivery, from classification and synthesis, to applications and regulatory factors. It presents the oral delivery?of therapeutics for treating a number of diseases, along with the challenges of oral drug administration to assure a predictive and reproducible pharmacokinetic profile of active pharmaceutical ingredients (API).
Polymers play an important role to achieve the targeted release profile consistently of an API in vivo by various functionalities like drug protection from gastric juice, fast release and supersaturation or release within a targeted area of the GI tract.
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Table of Contents
Section A. Fundamentals of Oral Drug Delivery 1. GI tract environment (e.g. gastric juice, bile salts, pH, amylases, proteases etc.) 2. GI tract motility and transport 3. Drug absorption and pre-systemic metabolism and PK modelling 4. In vitro dissolution and predictive release testing 5. Principle characteristics and specification of pharmaceutical polymers 6. Regulatory Aspects of Polymers Used and new polymers for Oral Medication Section B. Role Polymer Technology in Oral Drug Delivery 7. Classes/types of polymers used in oral delivery (natural, semi-synthetic, synthetic), their chemical structure and general functionalities 8. Role of polymers in Tableting 9. Capsule forming Polymers 10. Dry and wet Granulation 11. Matrix formers 12. Functional Polymer Coatings (IR, easy to swallow, enteric etc.) 13. Amorphous systems (e.g. HME, SD) 14. Micro/Nanoparticles 15. Taste masking polymers 16. Polymers in Orally disintegrating tablets and Orally dissolving films 17. Additive manufacturing (3D printing) 18. Mucoadhesive forms 19. Gastro-retentive forms 20. Polymer blends and additives
Authors
Anilkumar Parambath YTY Group, Indorama Corporation, Perak, Malaysia.Dr Anilkumar Parambath is Senior R&D Manager of YTY Group, Indorama Corp., Perak, Malaysia. Prior to this, he was R&D Manager, Science & Technology at Unilever (2021-2024); Senior Manager and Head of Capsules Product R&D, ACG Capsules, Mumbai, India (2018-2021) and Principal Investigator for Performance and Specialty Materials at Syngene International Ltd, Bangalore India (2017-2018), where he worked on developing various elastomers, silicones, acrylics and other polymers for biomedical applications. He completed his PhD in Chemistry (Polymer Science) at the University of Kerala, India, and spent 7 years conducting post-doctoral research at Clemson University, USA, French atomic Energy Commission (CEA), France, and the University of British Columbia, Canada. HIs expertise is in polymer science, materials science, green chemistry, nanotechnology, nanomedicine, and biomaterials science. Dr. Parambath has edited three books on polymer biomaterials in drug delivery applications, including two with Elsevier, and has published many books chapters and journal articles. He has two patents to his name. In 2024, he was recognized by the American Chemical Society (ACS) as a Sustainability Star.
