Translational Models of Parkinson's Disease and related Movement Disorders

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Book
November 2024
Elsevier Science and Technology
ID: 5954955

Translational Models of Parkinson's Disease and Related Movement Disorders focuses on cutting-edge techniques for creating and validating current Parkinson's Disease translational experimental models. Various characteristics of these models are examined, including the prion-like properties of -synuclein, mitochondrial functions connected to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway connected to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells). This book also highlights the future possibilities of introducing new models for Parkinson's Disease and related movements disorders, underscoring current advancements, pre-clinical and clinical developments, and future scope related to numerous models.

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Section I. Understanding PD and related movement disorders
1. Neuroinflammation, glymphatic system, and Parkinson's disease
2. Pharmacotherapy of PD and related movements disorders and their limitations
3. Diagnosis and biomarkers of Parkinson's disease and related movement disorders
4. OMICS and bioinformatics in Parkinson disease and related movements disorders
5. Modeling Parkinson's disease with the alpha-synuclein protein
6. ?-Synuclein seeding assay and analysis
Section II. Mammalian models of Parkinson's disease
7. SHH, nurr1, pitx3, and en1 models for Parkinson's disease
8. Stem cell for PD: Technical considerations
9. Deep brain stimulation using animal models of Parkinson's disease
10. The MitoPark mouse model of Parkinson's disease
11. The beta-sitosterol beta-D-glucoside (BSSG) rat model of Parkinson's disease
Section III. Invertebrate models of Parkinson's disease
12. SCA1 zebrafish model
13. Various zebrafish models of Parkinson's disease: What gives us hope
14. Drosophila PD model
15. Caenorhabditis elegans models of tauopathy
16. LRRK2 in Caenorhabditis elegans model
Section IV. Ethics and regulations related to translational PD models
17. Confounding factors for validation of PD models
18. Neurobehavioral characterization of PD models
19. Ethical regulations for induction and validation of PD models
20. The OMICS and PD models: Hopes or hypes
21. Parkinson's disease from an Ayurveda perspective: Opportunities and challenges for further research

Authors

Wael Mohamed Assistant Professor, Basic Medical Science Dept., Medical School, International Islamic University Malaysia, Kuantan Campus, Pahang, Malaysia. Dr Mohamed is a Psychiatrist Neuroscientist. He earned his medical degree from Menoufia Medical School, Egypt and his research doctorate degree from the Penn State University, USA. After finishing his training in the neurosurgery department, he started his career as a clinical pharmacologist with psychopharmacology as a subspecialty. Currently, he is an assistant professor in IIUM, Malaysia as well as he is a doctorate student in cognitive psychology, IIUM, Malaysia. His translational brain research targets the investigation and development of novel treatment for AD and PD using rat, mice, and Zebra Fish animal models.

Table of Contents

Authors

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