The fatty substance known as cholesterol is found in every cell of the human body and carries out several important functions. It is transported through the bloodstream as a part of particles called lipoproteins, which are divided into classes including low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Distinguishing between these two classes, along with the ‘remnant cholesterol’ particles that have recently been associated with heightened risk of heart disease and stroke, is a crucial part of managing health and developing novel pharmaceuticals.
Cholesterol, Lipoproteins, and Cardiovascular Health offers a thorough and rigorous overview of these particles, their properties, and their methods of categorization. Surveying both the characteristics of lipoproteins and their interactions with diet, lifestyle, therapeutics, and general health, it’s an indispensable guide to these particles that can literally mean the difference between life and death. Cutting-edge and grounded in the latest research, it’s a one-stop shop for understanding blood plasma lipoproteins in all their major forms.
Cholesterol, Lipoproteins, and Cardiovascular Health readers will also find: - Detailed discussion of topics including basic lipoprotein biochemistry, targeted therapeutics and drug development, and many more- Easily readable overview of the current state of research into lipoproteins and their likely future applications- Rich illustrative material enhanced by a graphical abstract at the beginning of each section offering a summary of crucial content
Cholesterol, Lipoproteins, and Cardiovascular Health is suited for professionals, clinicians, and readers looking for a comprehensive overview of all aspects of plasma lipoproteins and their role in heart disease and stroke.
Table of Contents
Brief History of Lipoproteins xi
Preface xiii
Acknowledgments xvii
Abbreviations xix
Prologue xxi
Setting: Realms of Molecules, Cells and Diseases 1
1 Covert World of Molecules 3
2 Enigmatic World of Cells and Organs 15
3 Shadowy World of Diseases 21
Characters: Lipoproteins of Human Blood 55
Main Character One: LDL, Carrier of "Bad" Cholesterol 69
4 LDL - Why It Is Important 71
5 LDL-What It Is 93
6 LDL - Where It Comes From 105
7 LDL-What It Does 109
8 LDL - How It Stops Working 115
9 LDL - What to Do to Correct It 131
Main Character Two: HDL, Carrier of "Good" Cholesterol 155
10 HDL - Why It Is Important 157
11 HDL - What It Is 171
12 HDL - Where It Comes From 195
13 HDL - What It Does 209
14 HDL - How It Stops Working 221
15 HDL - What To Do To Correct It 233
Main Character Three: Triglyceride-Rich Lipoproteins, Carriers of Remnant Cholesterol 259
16 Remnant Cholesterol - Why It Is Important 261
17 Remnant Cholesterol - What It Is 269
18 Remnant Cholesterol - Where It Comes From 283
19 Remnant Cholesterol - What It Does 289
20 Remnant Cholesterol - How It Stops Working 295
21 Remnant Cholesterol - What to Do to Correct It 305
Test Your Knowledge 318
Answers 320
Further Reading 321
Epilogue 325
Glossary 327
Index 333
