Firestein & Kelley's Textbook of Rheumatology, 2-Volume Set. Edition No. 12

Table of Contents

VOLUME I
1 Developmental Biology, Organization, and Function of the Synovial Joints
2 Synovium
3 Cartilage and Chondrocytes
Development and Biology of Bone
5 Muscle Anatomy, Physiology, and Biochemistry
6 Biomechanics
7 Regenerative Medicine and Tissue Engineering
8 Proteinases and Matrix Degradation
9 Dendritic Cells
10 Mononuclear Phagocytes
11 Neutrophils
12 T Lymphocytes
13 B Cells
14 Fibroblasts and Fibroblast-like Synoviocytes
15 Mast Cells and Basophils
16 Innate Lymphoid Cells and Natural Killer Cells
17 Platelets and Megakaryocytes
18 Principles of Signaling
19 Innate Immunity
20 Adaptive Immunity
21 Immune Tolerance and Autoimmunity
22 Pre-clinical Autoimmunity
23 The Microbiome in Rheumatic Diseases
24 Genetics of Rheumatic Diseases
25 Epigenetics of Rheumatic Diseases
26 Complement System
27 Prostaglandins, Leukotrienes, and Related Compounds
28 Angiogenesis
29 Cytokines and Chemokines
30 Neuronal Mechanisms of Pain and Inflammation
31 Clinical Research Methods in the Rheumatic Diseases
32 Epidemiology and Impact of Rheumatic Diseases
33 Assessment of Health Outcomes
34 Biomarkers in Rheumatology
35 Occupational, Environmental, and Recreational Musculoskeletal Disorders
36 Cardiovascular Risk in Inflammatory Rheumatic Disease
37 Cancer Risk in Rheumatic Diseases
38 Occupational Therapy, Physical Therapy, and Rehabilitation
39 General Principles of Pregnancy and Rheumatic Disease: Pre-pregnancy Assessment
40 History and Physical Examination of the Musculoskeletal System
41 Ultrasound in Rheumatology
42 Evaluation of Monoarticular and Polyarticular Arthritis
43 Skin and Rheumatic Diseases
44 The Eye and Rheumatic Diseases
45 Neck Pain
46 Shoulder Pain
47 Low Back Pain
48 Hip and Knee Pain
49 Foot and Ankle Pain
50 Hand and Wrist Pain
51 Temporomandibular Joint Disorders
52 Fibromyalgia
53 Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology
54 Arthrocentesis and Injection of Joints and Soft
Tissues
55 Anti-nuclear Antibodies
56 Autoantibodies in Rheumatoid Arthritis
57 Acute Phase Reactants
58 Imaging in Rheumatic Diseases
VOLUME II
59 Therapeutic Targeting of Prostanoids
60 Glucocorticoid Therapy
61 Traditional DMARDs: Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies
62 Immunosuppressive Drugs
63 Anti-cytokine Biologics
64 Cell-Targeted Biologics and Emerging
Targets: Rituximab, Abatacept, and Other Biologics
65 Janus Kinase and Other Intra-cellular Targets
66 Urate-Lowering Therapy
67 Bisphosphonates
68 Analgesic Agents in Rheumatic Disease
69 Nutrition and Rheumatic Diseases
70 Etiology of Rheumatoid Arthritis
71 Pathogenesis of Rheumatoid Arthritis
72 Clinical Features of Rheumatoid Arthritis
73 Treatment of Rheumatoid Arthritis
74 Sj�gren’s Syndrome
75 Classification and Epidemiology of Spondyloarthritis
76 Axial Spondyloarthritis
77 Reactive Arthritis
78 Psoriatic Arthritis
79 Inflammatory Bowel Disease-Associated Arthritis and Other Enteropathic Arthropathies
80 Etiology and Pathogenesis of Systemic Lupus Erythematosus
81 Clinical Features of Systemic Lupus Erythematosus
82 Treatment of Systemic Lupus Erythematosus
83 Antiphospholipid Syndrome
84 Etiology and Pathogenesis of Systemic Sclerosis
85 Clinical Features and Treatment of Scleroderma
86 Inflammatory Diseases of Muscle and Other Myopathies
87 Overlap Syndromes
88 Classification and Epidemiology of Systemic Vasculitis
89 Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu’s Arteritis
90 Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis
91 Polyarteritis Nodosa
92 Immune Complex-Mediated Small Vessel Vasculitis
93 Primary Central Nervous System Vasculitis
94 Beh�et’s Disease
95 Pathogenesis of Inflammasome-Mediated Diseases
96 Etiology and Pathogenesis of Hyperuricemia and Gout
97 Clinical Features and Treatment of Gout
98 Calcium Crystal Disease: Calcium Pyrophosphate Deposition Disease and Basic Calcium Phosphate-Associated Syndromes
99 Familial and Nonfamilial Autoinflammatory Syndromes
100 Etiology and Pathogenesis of Osteoarthritis
101 Clinical Features of Osteoarthritis
102 Treatment of Osteoarthritis
103 Metabolic Bone Disease
104 Proliferative Bone Diseases
105 Osteonecrosis
106 Relapsing Polychondritis
107 Heritable Diseases of Connective Tissues
108 Etiology and Pathogenesis of Juvenile Idiopathic Arthritis
109 Clinical Features and Treatment of Juvenile Idiopathic Arthritis
110 Childhood-Onset Systemic Lupus Erythematosus, Drug-Induced Lupus in Children, and Neonatal Lupus
111 Juvenile Dermatomyositis, Scleroderma, and Vasculitis
112 Bacterial Arthritis
113 Lyme Disease
114 Mycobacterial Infections of Bones and Joints
115 Fungal Infections of Bones and Joints
116 Rheumatic Manifestations of Human Immunodeficiency Virus Infection
117 Viral Arthritis
118 Rheumatic Fever and Post-streptococcal Arthritis
119 COVID-19 and Rheumatic Disease
120 Vaccination in Rheumatic Disease
121 Amyloidosis
122 Sarcoidosis
123 Hemochromatosis
124 Hemophilic Arthropathy
125 Rheumatic Manifestations of Hemoglobinopathies
126 IgG4-Related Disease
127 Arthritis Accompanying Endocrine and
128 Rheumatic Paraneoplastic Syndromes and Malignancies With Rheumatic Manifestations
129 Tumors and Tumor-like Lesions of Joints and Related Structures
130 Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer

Authors

Gary S. Firestein Distinguished Professor of Medicine, Senior Associate Vice Chancellor for Health Sciences, Director, Altman Clinical & Translational Research Institute. Gary Firestein, MD, is a board-certified rheumatologist who diagnoses and treats patients with autoimmune conditions as well as diseases of the joints, muscles and bones. A professor at UC San Diego School of Medicine, Dr. Firestein is distinguished for his research and serves as director of the Altman Clinical and Translational Research Institute and the senior associate vice chancellor for health sciences. Dr. Firestein's research interest focuses on the pathogenesis and treatment of rheumatoid arthritis.
Dr. Firestein is the recipient of many awards and honors, including the Arthritis Foundation's Jane Wyman Humanitarian Award in 2010 for his contributions to rheumatology; the Arthritis Foundation Lee C. Howley Sr. Prize for Arthritis Research; and the American College of Rheumatology Distinguished Investigator Award. He has been elected to the American Society for Clinical Investigation and the Association of American Physicians. He has served as an editor for the Textbook of Rheumatology for since the 7th edition (2004). Iain B McInnes Muirhead Professor of Medicine, Arthritis Research UK Professor of Rheumatology, Director of Institute of Infection,Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom. Iain McInnes is Director of the Institute of Infection, Immunity and Inflammation at the University of Glasgow, UK. He has extensive experience in leading multicenter programs nationally and internationally. He is Director of the Scottish MRC Clinical Pharmacology and Pathology Clinical PhD Training Program, Chief Investigator for the Scottish Early RA Cohort (SERA) and the related SMS-IC biomarker discovery program (PROMISERA), and chief investigator of numerous global phase II and III clinical trials of novel immune therapies. He has served as member or chair of numerous national grant-funding panels and as chair of several European League Against Rheumatism (EULAR) scientific committees - he is now Treasurer and President Elect of EULAR serving on its Steering Committee. He is formerly Chairman of the Foundation for European Rheumatology Research (Foreum) Scientific Committee and leads the EULAR-supported European Roadmap Program that is defining the research agenda for rheumatology for the next decade. Gary Koretzky Vice Dean at Weill Cornell Medical College, Frank H.T. Rhodes Distinguished Professor of Cardiovascular Biology and Genetics.. Gary Koretzky, MD, PhD is Professor of Medicine at Weill Cornell Graduate School. Dr. Koretzky's research aims to better understand the signal transduction events that occur following engagement of the T cell antigen receptor. He has been continuously funded by the National Institutes of Health since establishing his independent research group, as the laboratory has expanded its interests to study more globally the molecular events important for immune cell development, differentiation and function. Dr. Koretzky has published more than 200 research articles. He is a past President of the American Society of Clinical Investigation (2000) and Councilor of the Association of American Physicians (2008-2012), is a Fellow of the American Association for the Advancement of Science (2004), a member of the Institute of Medicine of the National Academies (2008), a Fellow of the American Academy of Arts & Sciences (2012) and serves as the Editor-in-Chief of Immunological Reviews (2002-present). Ted Mikuls Stokes Shackleford Professor and Vice-Chair for Research, Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center. Dr. Mikuls is a rheumatologist and epidemiologist with research interests focused on the epidemiology, pathogenesis, and outcomes of rheumatoid arthritis (RA) and gout. He is actively engaged in clinical/translational research activities and has received research funding from the NIH, U.S. Department of Defense, Veterans Affairs, the Rheumatology Research Foundation, and industry. He has extensive experience conducting multi-center / multidisciplinary trials, serving as the Principal Investigator (PI) for the multicenter Veterans Affairs Rheumatoid Arthritis (VARA) registry since its inception in 2003. He has served on multiple national study sections including those convened by the NIH, VA, and the Rheumatology Research Foundation. He previously chaired the American College of Rheumatology (ACR) Subcommittee for Practice Guidelines, served on the US FDA's Arthritis Advisory Committee, and was the Lead Editor for the textbook A Color Handbook - Rheumatology. Tuhina Neogi Section Chief of Rheumatology, Rheumatology, Professor, Rheumatology, Boston University School of Medicine. Tuhina Neogi is a rheumatologist and epidemiologist whose research has focused primarily on risk factors for knee osteoarthritis and gout, pain mechanisms in knee osteoarthritis, as well as methodologic issues of relevance for rheumatic diseases. Dr. Neogi has had continuous peer-reviewed foundation and NIH funding since 2003 and has over 250 peer-reviewed publications to date. She is a past chair of the FDA Arthritis Advisory Committee, serve(d) on the boards of two international societies: Osteoarthritis Research Society International (OARSI) and Gout, Hyperuricemia, and Crystal-Associated Diseases Network (G-CAN), and on committees for the American College of Rheumatology (ACR) and International Association for the Study Pain (IASP), among others. Her work has been recognized with the prestigious 2014 ACR Henry Kunkel Young Investigator Award for outstanding and promising independent contributions to rheumatology research and she has also engaged in developing new classification criteria for a number of rheumatic diseases. James R. O'Dell Bruce Professor and Vice Chairman of Internal Medicine, University of Nebraska Medical Center, Chief of Rheumatology, Department of Medicine, Omaha Veterans Affairs, Omaha, Nebraska. James R. O'Dell, MD is the Stokes Shackleford Professor of Internal Medicine, Vice-Chairman of Internal Medicine and Chief of the Division of Rheumatology at the University of Nebraska Medical Center (UNMC) in Omaha. Dr. O'Dell founded and has directed the Rheumatoid Arthritis Investigational Network (RAIN) for the last 25 years. Dr. O'Dell is the PI of the large multinational RA research study based at the VA through their cooperative studies program. Dr. O'Dell has published extensively, mostly in the area of rheumatoid arthritis. He has presented frequently at national and international meetings and has more than 100 published articles in top-level rheumatology journals. He has served on numerous American College of Rheumatology (ACR) committees over the last 20 years, including time on both the ACR and REF BOD, as well as a two-year term as President of the Research and Education Foundation of the ACR and was President of the College (2011-2012). Additionally, he is Editor-in-Chief of Up To Date for Rheumatology.