This book summarizes the cutting-edge experimental research on heterocyclic compounds used as anti-inflammatory agents in ten chapters. Each chapter is authored by experts in medicinal chemistry and is supplemented with scientific references for advanced reading.
The book covers several types of heterocyclic compounds and their derivatives including
- Pyrimidine and pyrimidinone derivatives
- 1,2,3, and 1,2,4 triazoles
- Imidazole and benzimidazole derivatives
- Oxazole, oxadiazole, isoxazoline, and oxazoline derivatives
- Thiazole and thiazolidinone derivatives
- Pyrazole and pyrazoline
- Carbazoles and their derivatives
- Azipines, quinolines, and coumarins
This is a timely reference for medicinal chemists interested in developing new heterocycles for anti-inflammatory drugs. Contributors have discussed the effects of these compounds on different types of inflammation and their evolution in drug development as therapeutic agents to give a wider perspective to readers.
Table of Contents
Chapter 1 Pyrimidine and Pyrimidinone Derivatives as Antiinflammatory Agents
- Introduction
- C Hemistry of Pyrimidine Derivatives as Anti-Inflammatory Agents
- Chemistry of Pyrimidinones as Anti-Inflammatory Agents
- Conclusion
- List of Abbreviations
- Consent for Publication
- Acknowledgments
- References
Chapter 2 Triazoles and Their Derivatives as Anti-Inflammatory Agents
- Introduction
- Chemistry of 1,2,3-Triazoles as Anti-Inflammatory Agents
- Conclusion
- List of Abbreviations
- Consent for Publication
- Acknowledgments
- References
Chapter 3 Imidazole and Benzimidazole Derivatives as Antiinflammatory Agents
- Introduction
- Tautomerism in Benzimidazole
- Chemistry of Imidazole Derivatives as Inflammatory Activity
- Chemistry of Benzimidazole Derivatives as Inflam- Matory
- Activity
- Conclusion
- List of Abbreviations
- Consent for Publication
- Acknowledgments
- References
Chapter 4 Oxazole, Oxadiazole, Isoxazoline and Oxazoline Derivatives as Anti-Inflammatory Agents
- Introduction
- Conclusion
- List of Abbreviations
- Consent for Publication
- Acknowledgments
- References
Chapter 5 Thiazole and Thiazolidinone Derivatives as Antiinflammatory Agents
- Introduction
- C Hemistry of Thiazole Derivatives as Anti-Inflammatory Agents
- Chemistry of Thiazolidine as an Anti-Inflammatory Agent:
- Significance of Thiazole and Thiazolidinone Derivatives in Antiinflammatory
- Research
- Mechanism of Anti-Inflammatory Action of Thiazole And
- Thiazolidinone Derivatives
- Inhibition of Pro-Inflammatory Cytokines
- Inhibition of Enzymes Involved in the Production of Inflammatory Mediators
- Antioxidant Activity
- Inhibition of Transcription Factors
- Conclusion
- List of Abbreviations
- Consent for Publicaton
- Acknowledgments
- References
Chapter 6 Pyrazole and Pyrazoline Derivatives as Anti-Inflammatory Agents
- Introduction
- C Hemistry of Pyrazole Derivatives as Anti-Inflam- Matory Agents
- Pyrazoles-Based Commercially Used Anti-Inflam- Matory
- Compounds
- Chemistry of Pyrazoline Derivatives as Anti-Inflammatory
- Agents
- Conclusion
- Consent for Publication
- Acknowledgments
- List of Abbreviations
- References
Chapter 7 Carbazoles and Their Derivatives as Anti-Inflammatory Agents
- Introduction
- C Arbazoles and Their Derivatives as Anti-Inflam- Matory Agents 146
- Conclusion
- Consent for Publication
- Acknowledgments
- List of Abbreviations
- References
Chapter 8 Azepines and Their Derivatives as Anti-Inflammatory Agents
- Introduction
- Chemistry of Azepines as Anti-Inflammatory Agents
- Conclusion
- Consent for Publication
- Acknowledgments
- List of Abbreviations
- References
Chapter 9 Quinoline and Their Derivatives as Anti-Inflammatory Agents
- Introduction
- C Hemistry of Quinoline Derivatives as Anti-Inflam- Matory Agents 184
- Conclusion
- Consent for Publication
- Acknowledgments
- List of Abbreviations
- References
Chapter 10 Coumarins and Their Derivatives as Anti-Inflammatory Agents
- Introduction
- Overview of Coumarin and Some Common Drugs Possess Antiinflammatory
- Property
- Classification of Coumarin
- Synthesis & Anti-Inflammatory Activity
- Conclusion
- Consent for Publication
- Acknowledgments
- List of Abbreviations
- References
- Subject Index
Author
- Anjaneyulu Bendi
- M. P. Kaushik
- Neera Raghav
