Exosome Communication: Advances in Research and Therapeutics for Health and Disease serves as a crucial reference for pharmaceutical scientists, focusing on the key qualities of exosomes as drug delivery vehicles. Exosomes are intracellular membrane-based vesicles with diverse compositions, offering significant advantages over traditional drug delivery systems such as liposomes and polymeric nanoparticles, due to their nonimmunogenic nature. This book provides a comprehensive exploration of exosomes, starting with their history and development, understanding extracellular vesicles and biogenesis, and techniques for isolation and characterization. This book also addresses critical considerations like quality control, heterogeneity reduction, regulatory and ethical aspects, clinical trials, and scale-up manufacturing.
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Table of Contents
1. Introduction: History and Development of Exosomes Nanovesicles2. Exploring Extracellular Vesicles: Understanding Exosomes and Beyond
3. Exosome Isolation Techniques: Methods, Protocols, and Best Practices
4. Improving Cargo Loading and Release Strategies for Exosomes Nanovesicles
5. Exosome Characterization Techniques, Composition Analysis and Contents of Exosomes Nanovesicles: Methods and Interpretation
6. Quality Control, Minimizing Heterogeneity and Enhancing Yield in Exosome Isolation and Production
7. Inhibition of Cell-Cell Communication in Exosomes
8. Modifications of Exosomes Nanovesicles for Targeted drug delivery
9. Challenges for the Development of Exosome Nanovesicle-Based Formulations for Drug Delivery and Assessing Toxicity
10. Diagnostic Potential and Biomarkers Potential of Exosome Nanovesicles
11. Exosomes in Immunology
12. Exosomes in Protein and Peptide Delivery
13. Exosomes Nanovesicles in Antigen-Specific Antibody Delivery, Gene Delivery, and Vaccine Delivery
14. Theranostic Potential of Exosomes in Neurodegenerative Diseases
15. Exosomes in Cancer Therapeutic Delivery
16. Potential Role of Microbial-derived Exosomes in Human Health and Diseases
17. Current Applications of New Generations of Exosomes Nanovesicles
18. Clinical Trials and Translational Research in Exosome Nanovesicle Therapeutics
19. Scale-up and Manufacturing of Exosome-based Therapeutics
20. Regulatory and Ethical Considerations in Exosome-Based Therapeutics
Authors
Dalapathi Gugulothu Delhi Institute of Pharmaceutical Sciences and Research, India.Dr. Dalapathi Gugulothu working as Assistant professor, Department of Pharmaceutics , Delhi Institute of Pharmaceutical Sciences and Research, Delhi Pharmaceutical Sciences and Research University , New Delhi.
Dharmendra Kumar Khatri NIPER Hyderabad, india.Dr. Dharmendra Kumar Khatri is an Associate Professor in the Department of Pharmacology, NIMS Institute of Pharmacy at NIMS University Rajasthan, Jaipur, India.
Lalitkumar K. Vora Lecturer, School of Pharmacy, Queen's University, Belfast, UK.Dr. Lalitkumar K. Vora is a Lecturer at the School of Pharmacy, Queen's University, Belfast, and was included in Stanford's top 2% of world scientists list in 2023.
William C.S. Cho Queen Elizabeth Hospital, Hong Kong.Dr. William C. Cho, Highly Cited Researchers in 2023 by Clarivate. Dr. Cho has published over 600 SCI peer-reviewed papers; he is the world's top 0.1% most influential scientists in the world.
